User blog comment:GrandMethuselah67/Lore Sheet: The Democratic Imperium of Neohumanity/@comment-4867780-20150916222115/@comment-26322734-20150917041107

There are rules the people follow. It's not like they're skipping into another universes, flexing their transhuman muscles and screaming, "I'M GOD!" No, it's are strictly enforced rules that they blend in with the crowds, never directly interfering with other affairs unless absolutely necessary. By all intents and purposes, the very existence of the Imperium is secret to other universes to avoid unnecessary conflicts. If they do gain any trans-universal enemies, it's dealt with very professionally, with diplomacy and negotiation coming first and military action and armed conflict coming second.

As for conflicts and the countless forces that may oppose Neohumanity, the Imperium's foreign policies and tendancies towards negotiating help a lot for making sure they have no enemies (because let's face it, realistically, most people and, by extension, civilizations aren't bloodthirsty omnicidal maniacs). If, however, it does come to armed conflict (which is unlikely due to the immense damage a war with the Imperium would cause; it'd be a Pyrric Victory at best), then the Imperium has armed forces for a reason. If said civilization they're going against is substantially stronger than them, then the Imperium can just evacuate the universe entirely. They have the means and everything, and it'll be easy staying connected since they have the Human Mind Network.