Think about; if you have a sword, which one is worse, not being able to cut your opponent at all or the wounds you cut instantly healing? They both make your opponent essentially impervious to damage.
If they're both Absolute levels then it doesnt matter but I'd assume durability is worse to face off against as whatever you use to attack could break or take damage instead. While regeneration wears out resources (stamina, ammunition, etc...)
I think it was more about if you had to face off against one which one would be worse to fight against someone with insane durability or someone with insane regeneration.
With Regeneration, you could at least immobilize them. Depending on the level of their regeneration, you could disable their legs, or use tranquilizers, which give you some opening to transport them where they could be imprisoned forever.
I'd rather fight an opponent that could die but get back up rather than an opponent that can't die at all.