No because the penance stare only works if the target feels guilt I think and that's why the punisher in marvel was unharmed cus regardless of how many people he killed he felt no remorse.

Well the Ghost Rider can adjust how deadly the Penance Stare can work. And it has worked on Punisher in the past.

If we’re talking ghost riders then ya, the more evil someone’s soul is the stronger the flames burn iirc

It should

Nope, won't ever!

Maybe

The correct answer is Maybe because the Penance Stare is involved in many iterations that change whatever it does. If we go by the most common, the fact of the penance stare working only if the target feels guilt, then it won't work.

Although if we follow the original iteration, we got the Penance Stare that does harm an Omnimalevolent Being because it burns them with all the pain, guilt, despair, and madness that their victims underwent. All of it is being converted to spiritual flames that bring on spiritual harm that is not dependent on the guilt of the adversary.

Edit: Grammar.