Carnage Incarnate: Grand Chariot (Akame Ga Kill!) surrounds the wearer with a very powerful armor that is virtually indestructible.
Demon Armor: Incursio (Akame Ga Kill!) surrounds the wearer with a very powerful armor that is virtually indestructible.
Dispel Bound (Bastard!!) is a series of regenerating shields that provide absolute protection from virtually all forms of attack, including reality warping.
Genryūsai Shigekuni Yamamoto's (Bleach) Bankai, Zanka no Tachi, coats him with the flames of the sun that incinerates all attacks before they reach him.
Ight's (Breath of Fire IV) defense is so absolute that nothing short of a godlike berserker is able to penetrate it.
Sakura Kinomoto (Cardcaptor Sakura) using the Shield, creating a powerful magical defense that nothing short of powerful magic can break through.
Accelerator's (A Certain Magical Index/A Certain Scientific Railgun) vectors reflect any and all attacks passively, even teleporting vectors.
Saiai Kinuhata's (A Certain Magical Index) compressed nitrogen armor, Offense Armor, is a derivative of Accelerator's Redirection, and can block all attacks.
The Calculate Fortress (A Certain Magical Index) materials that the Windowless Building is composed of, and is said to be able to withstand all impacts, and strong enough to protect the building from a nuclear strike and remain unscathed.
The Magic Armor (The Legend of Zelda) protects Link from any and all damage so long as he has magic/rupees to fuel it.
The Third Raikage's (Naruto) Lightning Release Armor, along with his impenetrable durability and endurance, makes his body the "Strongest Shield".
Gaara's (Naruto) Ultimate Defense protects him from all forms of attacks due to the sand that contains his mother's will...
...and his most unbreakable defense, Absolutely Hard Defense: Shield of Shukaku, is composed of the hardest selected minerals.
The Hyuga Clan's (Naruto) Eight Trigrams Palms Revolving Heaven deflects all attacks from all directions, creating an absolute defense.
Itachi Uchiha's Susanoo (Naruto) wielded the Yata Mirror an ethereal shield able to change its characteristics to any nature transformation to completely negate any attack, whether it be spiritual, or physical.
Bartholomew Kuma's Paw Pads (One Piece) can deflect all forms of attacks back at his opponents, so long as he can have them catch the attacks in time.
Kaido (One Piece) has a nigh indestructible durability that renders him impossible to be killed by anyone even his own self.
In his Tank Man form, Monkey D. Luffy (One Piece) has tremendous Haki-based defenses that can withstand even the most powerful Haki enhanced attacks.
In his fortress golem form, Capone Bege (One Piece) is able to easily resist cannon-fire and withstand a prolonged assault from the immensely powerful Big Mom.
Charlotte Linlin/Big Mom's (One Piece) tremendously tough skin allows her to withstand being hit by a massive thunderbolt without a scratch.
Bartolomeo (One Piece) can create near unbreakable barriers with his Bari Bari no Mi ability.
Iron Clefts (Paper Mario: The Thousand-Year Door) possess such thick metallic skin that nothing can penetrate it except another Iron Cleft.
Bradley's Bat-Robo (RevEvolution) can transform into an indestructible shield.
Despite her looks, Yaya (Unbreakable Machine-Doll) has Kongōriki that can't be penetrated, except by other automaton's magic.
Aegis (Valkyrie Crusade) possess ultimate defense.
Prydwen (Valkyrie Crusade) is the avatar of a mighty shield that possesses an impenetrable defense which cannot be breached by any attack.
While his Stand 20th Century Boy is active, Magent Magent (Jojo's Bizarre Adventure Part VII: Steel Ball Run), is completely immune to attacks and damage inflicted upon him
Ancile (Valkyrie Crusade) can block any attack with her shield, but she only wants to use it as a mirror.
Georg (Highschool DxD) wields the ultimate barrier type Sacred Gear the Longinus Dimension Lost.
Daruk's Protection (The Legend of Zelda: Breath of the Wild)
As a Magi fueled by both White and Black Rukh Arba (Magi The Labyrinth of Magic) Bolg barrier has tremendous defensive power, able to easily defend against the Almighty Magic of Solomon's Djinns.
Hikone Ubuginu (Bleach) can combined its Arrancar's Hiero and Quincy's Blut Vene for a double-layered spiritual defense that could block the most powerful attacks from the strongest Shinigami.