The user has possession of an item/weapon/object that grants omnipotent powers or nigh omnipotence to its wielders, allowing the user to satisfy their every desire. The item/weapon/object allows the user to become a god. The user is virtually unstoppable and can do anything they want.
The Kanohi Ignika, the Legendary Mask of Life (BIONICLE)
Ring of Rage & Crown of Fire (Danny Phantom)
The Reality Gauntlet (Danny Phantom)
The Meta-Nanites (Generator Rex) are extremely powerful nanites that allow rex full control over Gravity, Space-Time, Matter, Anti-Matter, Energy, Elemental, Technology and much more.
The Infinite Gems/Stones (Marvel Comics) are six gemstones of incredible power. Any who posses them will either achieve, great power, the ability to travel through time and space, warp reality, control souls, and posses telekinetic powers. However…
…if they all are held in the Infinity Gauntlet, the bearer will gain nigh-omnipotent power.
Heart of the Universe (Marvel Comics)
The Tenth Metal/Element X (DC Comics), is the purest form of the creation itself; everything made in the DC Multiverse is made by it, only that it is in a weaker state. Any user of it (in its' pure form) obtains vast reality warping abilities, becoming nigh-omnipotent and capable of overwhelming anything from the Dark Multiverse.
Power Rings of Inspiron (Air Buddies)
Infinity Gems/Stones (Marvel Cinematic Universe)
A liquified form of the Reality Gem/Stone, Aether (Marvel Cinematic Universe) can control reality at the wielder's will.
Empowered by the Time Gem/Stone, the Eye of Agamotto (Marvel Cinematic Universe) have absolute power over time.
Mind Gem/Stone (Marvel Cinematic Universe)
Orb (Marvel Cinematic Universe) the Power Gem/Stone.
Empowered by the Space Gem/Stone, the Tesseract (Marvel Cinematic Universe) harnesses limitless cosmic energy and has absolute power over space and dimensions.
The Hōgyoku (Bleach) is a mighty item with the ability to manifest the desires of those around it, changing fantasy and dreams into reality. This grants many powerful abilities.
The Pandora Box (Code:Breaker) contains the Negation of December 32, which is strong enough to easily wipe out the entire Earth, and inside can also grant and augment special powers to people.
The Super Dragon Balls (Dragon Ball Super), when used, summon a nigh-omnipotent divine dragon that can grant any wish.
The Jewel of Four Souls (InuYasha) is a sacred jewel that possesses the ability to empower both humans and demons.
The Omni Cube (Bomberman 64) can trap galaxies into its interior, granting the wielder near invincibility and knowledge of the trapped civilizations.
The Blade of Olympus (God of War) is the most powerful weapon in the world. It was created by Zeus to end the Great War.
The Triforce (The Legend of Zelda) is the ultimate source of power in all of Hyrule. If anyone possesses the Trifroce of Power, Wisdom, and Courage, will have whatever they wish for granted.
Chaos Emeralds (Sonic the Hedgehog), are seven powerful gems that turn thoughts into power. However, if one manages to collect all seven, they will be granted ultimate power.
Master Emerald (Sonic the Hedgehog), is the master control to the seven Chaos Emeralds, and possess infinite and unbound powers that makes it the most powerful relic on Earth.
Sol Emeralds (Sonic the Hedgehog), are the counterparts to the Chaos Emeralds, granting the similar reality manipulating powers of space-time.
World Rings (Sonic the Hedgehog)
Chaos Crystals (Sonic Boom)
The Book of All Knowledge (Valkyrie Crusade) with its bearer.
CLUB SEGA (Yakuza) is the representation of the creator of entire Yakuza franchise in real life themselves, makes them omnipotent.