Archetype:Mad Scientist

Mad Scientist
Caesar Clown (One Piece), is a sadist mad scientist who creates WMDs capable of wiping out entire nations for fun and does highly unethical experiments.
Power/Ability to:	Use the archetypal traits of a mad scientist.

"You're weird, Morrow."

― Professor Anthony Ives to Professor Tomek Ovadya Morah/T.O. Morrow (DC Comics)

"So much has been done — more, far more, will I achieve: treading in the steps already marked, I will pioneer a new way, explore unknown powers, and unfold to the world the deepest mysteries of creation..."

― Victor Frankenstein (Frankenstein's Monster)

"Perhaps I shall dissect him once things calm down."

― Sei Kai (Kingdom)

"Ah hah hah hah! They called me mad at the university...and they were right!"

― Crazy Scientist (Lego Minifigures Series 4)

"Call it research. Call it madness. Call it art—it's all the same to me: I must know more."

― Cornelius Evazan (Star Wars)

The power to use the archetypal traits of a mad scientist.

Also Called

• Mad Alchemist
• Mad Chemist
• Mad Doctor/Psychologist
• Mad Gadgeteer/Inventor
• Mad Professor
• Mad Sorcerer/Sorceress

Capabilities

The user is a Mad Scientist, a scientist that dabbles in pseudoscience or does unethical/crazy experiments. They often can do science that breaks the laws of physics/nature.

Applications

• Biological Manipulation: The user can manipulate life on a cellular level, including but not limited to, genetic alterations and physical distortion and/or augmentations of biological functions. 
• Enhanced Adroitness: The user can precisely control their prehensile body parts, effectively manipulating any object, with grace, ease, strength, speed, precision, and skill.
• Enhanced Inventing/Supernatural Inventing/Absolute Inventing: Invent scientifically complex machinery, electronics, devices, gadgetry, or weaponry.
• Medical Intuition: The user has great, if not innate, medical knowledge, enabling them to easily treat others' injuries and create medicines.
  • Medical/Lab Weaponry Proficiency: Users demonstrate a unique aptitude for the way of medical/lab weaponry (sutures, saws, hypodermic needle, etc...)
• Peak Human/Enhanced/Supernatural/Absolute Intelligence: The user has intelligence that is significantly above the standard genius-level intellect; possessing exceptional intellectual capabilities
• Physics Defiance: Can defy any of the laws of physics, doing things such that they could not otherwise do as if the laws of physics were not there. from ignoring energy to ignoring the laws of motion.
• Pseudoscience Manipulation: Manipulate a form of "science" that cheats the scientific method.
  • Scifi Manipulation: Manipulate the imaginary form of Science known as Science-Fiction.
    • Artificial Life Creation: Can create a variety of artificial beings for a variety of purposes, including artificial constructs, genetically engineered lifeforms, or any combination of the two.
• Science Intuition: Has extraordinary skills with the study and utilization of the field of science to produce mass inventions, conduct experimentation, and perform accurate calculations.
  • Chemical Intuition: Can intuitively understand all types and forms of chemicals and chemistry.
  • Genetics Intuition: The user possesses an incredible and innate understanding/knowledge of genetics.
  • Mechanical Intuition: The user can intuitively understand the operation of any mechanical device and subconsciously/effortlessly create a schematic in their mind.
  • Robotics Intuition: The user is intuitively in the field of robotic engineering. This includes mechanical as well as electronic engineering as they pertain to the study of robotics and/or cybernetic implementation.
  • Virology Intuition
• Science Manipulation: The user can manipulate the laws of nature/science through a mundane method that manipulates reality to whatever effect they desire which can be interpreted as "super-science".
• Supernatural Surgery: The user can perform supernatural surgery, augmenting physiology/powers, and possibly even give new powers/abilities. They can treat incurable diseases/ailments and reanimate/resurrect the dead.
  • Brain Removal: The user can remove the brains (including only individual sections of the brain (the frontal lobe, motor cortex, occipital lobe, etc.) of oneself or others, usually resulting in the target's death.
  • Body Modification: The user can change and modify the bodies of oneself and others down to the genetic level, enhancing physical capabilities, modify it to be able to use certain powers, etc.
  • Body Part Substitution: The user can replace parts of their body with same organs from outside sources, gaining the powers they'd had before the connecting, such as an eye with night vision would give the ability to see in the dark, a hand taken from a plasma blaster could allow them to fire plasma blasts from that hand.
  • Stitching: The users can cause anything on their target to be "stitched" up/together, with applications attaching things to one another, reattaching limbs, binding things to any surface, closing wounds, etc.
  • Subsuming Transplantation: The user can overlay the limbs, organs, genetic traits of others while reordering their genetic makeup for easier assimilation, eliminating the fear of organ failure and biophysical rejection from donated body parts altogether.

Associations

• Chemical Magic: The user can utilize a form of magic that involves Chemistry, allowing for harnessing their magical energies and/or mystical control of their aspects.
  • Potion Creation: The user can create potions: substances with magical properties such as enhancing physical and mental abilities, healing, granting powers, changing shape, or bewitching someone depending on the kind of potion that is made.
• Forbidden Knowledge: The user is in possession of a dark and forbidden form of knowledge that was never meant for mortals to know. This kind of information can range from being scientific, magical, or eldritch in nature and can give the user access to abilities and capabilities far beyond human comprehension, not unlike the knowledge bestowed upon the user.
• Science-Magic Manipulation: The user can manipulate science and magic, how they interact/go together, how compatible they are, the results of science and magic going together, from how the technology works with magic and how chemicals are altered by magic, etc.
  • Alchemy

Limitations

• Breach of ethics and morality leaves users vulnerable to Punishment and Karma Inducement.
  • Their own creations and experiments may rise against them.
• Vulnerable to Corrupting Madness and Madness Manipulation.

Known Users

See Also: Mad Scientist, Mad Doctor, and Reluctant Mad Scientist.

Manhwa/Manga/Anime

• Kihara Clan (A Certain Magical Index)
  • Kihara Amata
  • Kihara Gensei
• Hange Zoe (Attack On Titan)
• Huey Laforet (Baccano!)
• Renée Brinvillier (Baccano!)
• Szilard Quates (Baccano!)
• Desty Nova (Battle Angel Alita)
• Mayuri Kurotsuchi (Bleach)
• Sosuke Aizen (Bleach)
• Szayelaporro Granz (Bleach)
• Edward Hamilton/The Elder (Chrono Crusade)
• Nina Einstein (Code Geass)
• Robert Schroeder (Darker Than Black)
• Rinichirō Hagire (Deadman Wonderland)
• Dr. Z (Dinosaur King)
• Dr. Myuu (Dragon Ball GT)
• Dr. Gero/Android 20 (Dragon Ball Z)
• Izaya Orihara (Durarara!!)
• Fran Madaraki (Franken Fran)
• Shou Tucker (Fullmetal Alchemist)
• Ryūzan Hayashi (Gintama)
• The Doctor (Hellsing)
• Miyo Takano (Higurashi: When They Cry)
• Sei Kai (Kingdom)
• Dr. Moro (Kirby: Right Back at Ya!)
• Sucy Manbavaran (Little Witch Academia)
• Grace O'Connor (Macross Frontier)
• Dr. Jail Scaglietti (Magical Girl Lyrical Nanoha StrikerS)
• Dr. Hell (Mazinger Z)
• Tem Ray (Mobile Suit Gundam)
• Ginias Sahalin (Mobile Suit Gundam: The 08th MS Team)
• Daruma Ujiko/Kyudai Garaki (My Hero Academia)
• Kabuto Yakushi (Naruto)
• Orochimaru (Naruto)
• Caesar Clown (One Piece)
• Dr. Hogback (One Piece)
• Butler (Pokemon)
• Charon (Pokemon)
• Cyrus (Pokemon)
• Dr. Fuji (Pokemon)
• Dr. Namba (Pokemon)
• Dr. Yung (Pokemon)
• Dr. Zager (Pokemon)
• Professor Sebastian (Pokemon)
• Zero (Pokemon)
• Souichi Tomoe (Sailor Moon)
• Hiroto Minaka (Sekirei)
• Dr. Ver/John Wayne Vercingetorix (Senki Zesshou Symphogear)
• Kululu (Sgt. Frog)
• Professor Franken Stein (Soul Eater)
• Akane Shinjo (SSSS.GRIDMAN)
• Akihiro Kanou (Tokyo Ghoul)
• Takatori Masafumi (Weiß Kreuz)
• Tsuji Mayumi (Weiß Kreuz: Glühen)
• Kozaky (Yu-Gi-Oh!)
• Magical Scientist (Yu-Gi-Oh!)
• Dr. Ichigaki (Yu Yu Hakusho)

Cartoons

• Princess Bubblegum (Adventure Time)
• Dr. Weird (Aqua Teen Hunger Force)
• Frylock (Aqua Teen Hunger Force)
• Algernop Krieger (Archer)
• Aloysius James Animo (Ben 10)
• Dr. Psychobos (Ben 10: Omniverse)
• Dr. Blood (Bolts and Blip)
• Doctor Blight (Captain Planet and the Planeteers)
• Professor XXXL (Codename: Kids Next Door)
• Dr. Gerbil (Courage the Cowardly Dog)
• Dr. Zalost (Courage the Cowardly Dog)
• The Cruel Vet (Courage the Cowardly Dog)
• Dexter (Dexter's Laboratory)
• Mandark (Dexter's Laboratory)
• Victor Veloci (DinoSquad)
• Van Kleiss (Generator Rex)
• Hubert Farnsworth (Futurama)
• Dr. Focus (Inspector Gadget)
• Professor Membrane (Invader Zim)
• Zim (Invader Zim)
• Olaf (Kaeloo)
• Dr. Drakken (Kim Possible)
• Dr. Locus (My Life as a Teenage Robot)
• Heinz Doofenshmirtz (Phineas and Ferb)
• Brain (Pinky and the Brain)
• Willem Viceroy III (Randy Cunningham: 9th Grade Ninja)
• Rick Sanchez (Rick & Morty)
• Entrapta (She-Ra and the Princesses of Power)
• Dr. Alphonse Mephesto (South Park)
• Sheldon J. Plankton (Spongebob Squarepants)
• Nuvo Vindi (Star Wars: The Clone Wars)
• Professor Chang (Teen Titans)
• Jimmy Neutron (The Adventures of Jimmy Neutron, Boy Genius)
• Dr. Fruitenstein (The High Fructose Adventures of Annoying Orange)
• Mojo Jojo (The Powerpuff Girls)
• Professor Frink (The Simpsons)
• Dr. Flug Slys (Villainous)
• Qilby (Wakfu)
• Zachary "Zach" Varmitech (Wild Kratts)
• Dr. Two-Brains (Wordgirl)

Comics/Web Comics

• Jyrras Gianna (Dan and Mab's Furry Adventures)
• Bug Baron (DC Comics)
• Doctor Cyclops (DC Comics)
• Doctor Death (DC Comics)
• Doctor Thaddeus Sivana (DC Comics)
• Doctor Tyme (DC Comics)
• Dr. Hugo Strange (DC Comics)
• Egg Fu (DC Comics)
• Ira Quimby/IQ (DC Comics)
• Komrade Krabb (DC Comics)
• Professor Achilles Milo (DC Comics)
• Professor Ivo (DC Comics)
• Rigoro Mortis (DC Comics)
• T.O. Morrow (DC Comics)
• Veronica Cale (DC Comics)
• Dr. Germahn (El Goonish Shive)
• Lord Tedd (El Goonish Shive)
• Tedd Verres (El Goonish Shive)
• Dr. Venom (G.I. Joe)
• Agatha Clay/Heterodyne (Girl Genius)
• Members of AIM (Advanced Idea Mechanics) (Marvel Comics)
• Arnim Zola (Marvel Comics)
• Hank Pym (Marvel Comics)
• Mister Sinister/Nathaniel Essex (Marvel Comics)
• The Intelligencia (Marvel Comics)
  • M.O.D.O.K./Mental Organism Designed Only For Killing
  • The Leader
  • The Mad Thinker
• Victor Von Doom (Marvel Comics)
• Dr. Catherine Crabtree (Sluggy Freelance)
• Dr. Irving Schlock (Sluggy Freelance)
• Dr. Scabmoreaueau (Sluggy Freelance)
• Dr. Steve Hereti (Sluggy Freelance)
• Riff (Sluggy Freelance)
• Baxter Stockman (Teenage Mutant Ninja Turtles)

Video Games

• Dr. Coyle (ARMS)
• Klungo (Banjo-Kazooie)
• Alice Angel (Bendy and the Ink Machine)
• Yi Suchong (BioShock)
• Kokonoe Mercury (Blazblue)
• Relius Clover (Blazblue)
• Dr. Thrax (Command and Conquer: Generals)
• Dr. Neo Cortex (Crash Bandicoot)
• Dr. N. Gin (Crash Bandicoot)
• Dr. Nitrus Brio (Crash Bandicoot)
• Bob Page (Deus Ex)
• The Master (Fallout)
• Dr. Stanislaus Braun (Fallout 3)
• Professor Calvert (Fallout 3)
• The Think Tanks (Fallout: New Vegas)
• Dr. Rachel Claudius (God Eater 2)
• Members of Aperture Science (Half-Life/Portal)
• Professor Von Yipp (Legends of Runeterra)
• Professor E. Gadd (Luigi's Mansion)
• Henry Lawson (Mass Effect)
• Dr. Wily (Megaman)
• Shang Tsung (Mortal Kombat)
• Moira (Overwatch)
• Dr. Edgar George Zomboss (Plants Vs. Zombies)
• Alex Mercer (Prototype)
• Dr. Nefarious (Ratchet & Clank)
• Umbrella Corp. staff (Resident Evil)
  • Albert Wesker
  • James Marcus
  • Oswell Spencer
  • William Birkin
• Brain Drain (Skullgirls)
• Valentine (Skullgirls)
• Doctor Eggman (Sonic the Hedgehog)
• Eggman Nega (Sonic the Hedgehog)
• Gerald Robotnik (Sonic the Hedgehog)
• Andross (Star Fox)
• Medic (Team Fortress 2)
• Dr. Roy Curien (The House of the Dead)
• Caleb Goldman (The House of the Dead 2)
• Alphys (Undertale)
• Guillaume (Vampire Night)
• Dr. Crygor (WarioWare Series)
• The Chemist (Zombie Night Terror)

Live Television/Movies

• Emmett L. Brown (Back to the Future)
• Professor Zündapp (Cars 2)
• Flint Lockwood (Cloudy with a Chance of Meatballs)
• Dr. Joseph Albert Nefario (Despicable Me)
• Davros (Doctor Who)
• Omega (Doctor Who)
• Rani (Doctor Who)
• Rassilon (Doctor Who)
• The Master (Doctor Who)
• The Other (Doctor Who)
• Julius No (James Bond)
• Henry Wu (Jurassic Park)
• Members of Shocker (Kamen Rider)
• Jumba Jookiba (Lilo & Stitch)
• Isaac Taft (Lost Girl)
• Megamind (Megamind)
• Dr. Cockroach (Monsters Vs. Aliens)
• Dragon King/Shiro Ito (Stargirl)
• Cornelius Evazan (Star Wars)
• Seth Brundle (The Fly)
• Syndrome (The Incredibles)
• Dr. Bunsen Honeydew (The Muppet Show)
• Dr. Finkelstein (The Nightmare Before Christmas)
• Herbert West (The Re-Animator)
• Frank-N-Furter (The Rocky Horror Picture Show)

Literature

• The Alchemists' Guild (Discworld)
• Dr. Frankenstein (Frankenstein’s Monster)
• Franny K. Stein (Franny K. Stein)
• Dr. Impossible (Soon I Will Be Invincible)
• Dr. Moreau (The Island of Doctor Moreau)
• Dr. Jekyll (The Strange Case of Dr. jekyll and Mr. Hyde)
• String Theory (Worm)

RPG

• Dr. Loctus Khan Schwarzwald (Anima: Beyond Fantasy)
• Dr. Arkadius (Hordes)
• Dr. McMourning (Malifaux)
• Belisarius Cawl (Warhammer 40,000)
• Fabius Bile (Warhammer 40,000)
• Stormsmith Storm Towers (Warmachine)

Web Animation/Web Original

• Dr. Bananas (Annoying Orange)
• Scientists of the SCP Foundation (SCP Foundation)
  • Doctor Jack Bright

Other

• The Brotherhood of Makuta (Bionicle)
  • Mutran
• Crazy Scientist (Lego Minifigures Series 4)
• Monster Scientist (Lego Minifigures series 14)
• Izzet League (Magic: The Gathering)
  • Niv-Mizzet
• Jin Gitaxias (Magic: The Gathering)
• Laboratory Maniac (Magic: The Gathering)
• Simic Combine (Magic: The Gathering)
  • Vannifar
• Yawgmoth (Magic: The Gathering)

Gallery

Anime/Manga/Manhwa

Kihara Amata (A Certain Magical Index), The Mad Scientist responsible for helping train Accelerator to use his Vector Manipulation.

Kihara Gensei (A Certain Magical Index) is mad scientist, and is obsessed of the creation of level 6 as well as the one responsible of Level 6 Shift attempt on Misaka Mikoto.

Hange Zoe (Attack on Titan) is a rare example of a Heroic Mad Scientist.

Huey Laforet (Baccano!)

Renée Brinvillier (Baccano!)

Szilard Quates (Baccano!) is an evil Mad Scientist or in this case Alchemist.

Desty Nova (Battle Angel Alita)

Mayuri Kurotsuchi (Bleach) is one of Soul Society's greatest scientists, though most of that is due to his lack of ethics and morality.

Sosuke Aizen (Bleach) is unusual for a Mad Scientist in that he likes it when his creations do something unexpected rather than the creations doing what he expects.

Szayelaporro Granz (Bleach) is a brilliant Arrancar scientist and represents the aspect of "madness" amongst the Espada.

Edward Hamilton (Chrono Crusade), A mild but still crazy Mad Scientist.

Nina Einstein (Code Geass)

Robert Schroeder (Darker Than Black)

Rinichirō Hagire (Deadman Wonderland

Dr. Z (Dinosaur King)

Dr. Myuu (Dragon Ball GT)

Doctor Gero/Android 20 (Dragon Ball Z), a mad scientist who created Androids in attempts for world domination, revenge and genocide.

Izaya Orihara (Durarara!!)

Fran Madaraki (Franken Fran), Mad Scientist who also has a lot of body horror.

Shou Tucker (Fullmetal Alchemist), A Mad Alchemist who combined his own daughter and Dog into a Chimera.

Ryūzan Hayashi (Gintama) was a scientist who developed the method to transcribe human mind as data, a forbidden technique.

The Doctor (Hellsing), The German Mad scientist working for the Millennium Forces.

Miyo Takano (Higurashi: When They Cry)

Sei Kai (Kingdom)

Using his Mad Science, Dr. Moro (Kirby: Right Back at Ya!) created dinosaur hybrids including a Kirby one.

Sucy Manbavaran (Little Witch Academia) is the Fantasy/Magical World equivalent of a Mad Scientist. She often comes up with new Potions and Poisons to experiment on unsuspecting people.

Grace O'Connor (Macross Frontier)

Jail Scaglietti (Magical Girl Lyrical Nanoha Strikers)

Dr. Hell (Mazinger Z)

Tem Ray (Mobile Suit Gundam), Father of Amuro, became a mad scientist after suffering oxygen deprivation which resulted in damage to his brain.

Daruma Ujiko/Kyudai Garaki (My Hero Academia) is responsible for creating Nomus: Monsters made from altered corpses that are able to use multiple powers. He's also a faithful servant of both All For One and Tomura Shigaraki.

Ginias Sahalin (Mobile Suit Gundam: The 08th MS Team)

Kabuto Yakushi (Naruto)

Orochimaru (Naruto), A Snake-Like Mad Scientist who has done plenty of genetics.

Dr. Hogback (One Piece), More of a Mad Doctor than a Scientist but does a lot of unethical experiments.

Butler's (Pokemon) Mad Scientist experiment involved using Jirachi as a power source.

Charon (Pokémon), Mad Scientist who works for Team Galactic and their plans to reshape reality.

Cyrus (Pokemon), Mad Scientist and Nihilist who wants to destroy the universe and remake it in his own image.

Dr. Fuji (Pokémon), Mad Scientist responsible for creating Mewtwo.

Dr. Namba (Team Rocket) is the craziest mad scientist in the Team Rocket Organization, Building lots of Ridiculous Inventions to capture Pokemon. He also gets triggered/angered whenever someone mispronounces his name.

Dr. Yung (Pokemon) planned to take over the world by using super-powerful pokemon holograms.

Dr. Zager (Pokemon), Monocle sporting Mad Scientist who works with Team Rocket.

Professor Sebastian (Pokemon) uses his Mad Science to mess with Radio Waves, His goal being to use these Radio Waves to force Pokemon to evolve or lure them.

Zero (Pokemon) is a Mad Scientist who's also a Yandere.

Souichi Tomoe (Sailor Moon), Mad Scientist and enemy to the Sailor Scouts.

Hiroto Minaka (Sekirei)

Dr. Ver/John Wayne Vercingetorix (Senki Zesshou Symphogear) is a Mad Scientist who's specialty is Relic Research.

Kululu (Sgt. Frog) is not only a Mad Scientist but also a Witch Doctor.

Dr. Franken Stein (Soul Eater)

Akane Shinjo (SSSS.GRIDMAN)

Akihiro Kanou (Tokyo Ghoul)

Takatori Masafumi (Weiß Kreuz)

Tsuji Mayumi (Weiß Kreuz: Glühen)

Kozaky (Yu-Gi-Oh!)

Magical Scientist (Yu-Gi-Oh!)

Dr. Ichigaki (Yu Yu Hakusho)

Cartoons

Princess Bubblegum (Adventure Time)

Dr. Weird (Aqua Teen Hunger Force)

Frylock (Aqua Teen Hunger Force), A Mad Scientist who is a living box of French Fries.

Algernop Krieger (Archer) is a mad scientist who once used the psychotropic drug Scopolamine.

Aloysius James Animo (Ben 10) is a Mad scientist who likes creating mutated animals/aliens.

Dr. Psychobos (Ben 10: Omniverse) is a Cerebrocrustacean Mad Scientist who created the Nemetrix, A omnitrix that contains the DNA of the predators to Ben's Aliens.

Dr. Blood (Bolts and Blip) is the Main Antagonist of the series and created a vampire robot that infected some of the robots on the moon.

Doctor Blight (Captain Planet and the Planeteers) represents the dangers of Uncontrolled Technology and Unethical Scientific Experimentation, Even other Mad Scientists hate her.

Professor XXXL (Codename: Kids Next Door) is a mad scientist who is determined to create the perfect snow cone.

Dr. Gerbil (Courage the Cowardly Dog), A Mad Scientist Gerbil who experiments on Humans.

Dr. Zalost (Courage the Cowardly Dog), Slavic Mad Scientist who uses cannonballs that make people unhappy.

The Cruel Vet (Courage the Cowardly Dog), A Mad Doctor who sent dogs into Outer Space in the hopes of making them into Super Dogs.

Dexter (Dexter's Laboratory), A Kid Mad Scientist who's a genius.

Mandark (Dexter's Laboratory)

Victor Veloci (DinoSquad) is a 65 Million year old Velociraptor disguised as a Human. He wants to use his mad science to turn Earth back to the age of the Dinosaurs.

Van Kleiss (Generator Rex) is a mad scientist who wants Earth to be entirely populated by E.V.O.'s. He has the power to steal nanites from others causing them to be petrified.

Professor Hubert J. Farnsworth (Futurama)

Dr. Focus (Inspector Gadget)

Professor Membrane (Invader Zim), A Mad Scientist who is the only smart man in his world.

Zim (Invader Zim), Ikren Mad Scientist and the Main Protagonist of the series.

Olaf (Kaeloo), is a Emperor Penguin Mad Scientist.

Dr. Drakken (Kim Possible)

Dr. Locus (My Life as a Teenage Robot) is famous for his creation: A Robotic Daughter named Melody.

Heinz Doofenshmirtz (Phineas and Ferb)

Brain (Pinky and the Brain) is an Anthropomorphic Lab Rat Mad Scientist. He's Smarter than Lab Rat Pinky.

Willem Viceroy III (Randy Cunningham: 9th Grade Ninja), Mad Scientist and Right Hand Man of Hannibal Mcfist.

Rick Sanchez (Rick & Morty)

Entrapta (She-Ra and the Princesses of Power), A Mad Scientist who's experiments are more tech based.

Dr. Alphonse Mephesto (South Park), Mad Scientist who likes giving animals multiple asses instead of one.

Sheldon J. Plankton (Spongebob Squarepants), Arch-Nemesis to Mr. Krabs and creator of Karen, his robotic wife.

Nuvo Vindi (Star Wars: The Clone Wars), A Faust Mad Scientist who wants to release a more deadly version of the Blue Shadow Virus.

Professor Chang (Teen Titans), Criminal Mad Scientist and enemy to the Teen Titans.

Jimmy Neutron (The Adventures of Jimmy Neutron, Boy Genius) has created many inventions including Goddard, His pet robotic dog.

Dr. Fruitenstein (The High Fructose Adventures of Annoying Orange) is a mad scientist cantaloupe who once shrunk orange and his friends in order for them to remove a small laser cannon implanted, by the Broccoli Overlord, in Nerville's Brain.

Mojo Jojo (The Powerpuff Girls) is a Chimpanzee Mad Scientist and Arch-Enemy of the Powerpuff Girls.

Professor Frink (The Simpsons), Springfield's Mad Scientist.

Dr. Flug Slys (Villainous)

Qilby (Wakfu)

While more of a Inventor than a Scientist Zachary "Zach" Varmitech (Wild Kratts) likes to perform experiments on wild animals he captures which includes mind control. His goal is to steal the Wild Kratt's technology and use the creature powers for himself. Also his most famous creations are his Zachbots.

Dr. Two-Brains (Wordgirl), Mad Scientist who loves cheese and has an extra brain on his head.

Video Games

Dr. Coyle (ARMS)

Klungo (Banjo-Kazooie), Orge-Like Mad Scientist and Igor/Minion to Gruntilda.

Alice Angel (Bendy and the Ink Machine)

Mad Scientist Yi Suchong (BioShock), The man behind the creation of the Little Sisters and the Big Daddies.

Kokonoe Mercury (Blazblue), A Heroic Mad Scientist counterpart to Relius Clover.

Relius Clover (Blazblue), The Villainous Mad Scientist Counterpart to Kokonoe Mercury.

Dr. Thrax (Command and Conquer: Generals) created a lot of Biological and Chemical weapons, using his mad science, including Anthrax that can melt vehicles.

Dr. Neo Cortex (Crash Bandicoot)

Dr. N. Gin (Crash Bandicoot)

Dr. Nitrus Brio (Crash Bandicoot)

Bob Page (Deus Ex), Though not very skilled with science himself, Respects it and uses it to create conglomerates that will help him rule the world.

The Master (Fallout)

Dr. Stanislaus Braun (Fallout 3)

Professor Calvert (Fallout 3) is a mad scientist that has become nothing but a brain in a jar.

The Think Tanks (Fallout: New Vegas) are a group of Mad Scientists who are brains inside a robot body, Allowing them to live past their biological life spans.

Dr. Rachel Claudius (God Eater 2), Vice Chief Supervisor of the Fenrir Friar Branch Aragami Technology Department.

Members of Aperture Science (Half-Life/Portal) are mad scientists that created many inventions such as the Portal Gun.

Professor Von Yipp (Legends of Runeterra) is a Cat Mad scientist who's Human Assistant is his translator. Unlike other Mad Scientists, He doesn't perform experiments himself. He scams humans to do them for him.

Professor E. Gadd (Luigi's Mansion) is a mad but heroic scientist who creates weapons designed to deal with bad ghosts.

Henry Lawson (Mass Effect)

Dr. Wily (Megaman), Mad scientist and Arch-Nemesis to Megaman.

While he is a more of a sorcerer than a scientist, Shang Tsung (Mortal Kombat) has conducted many experiments as well including the creation of Mileena.

Moira O’Deorain (Overwatch) is responsible for Gabriel Reye's Transformation to Reaper.

Dr. Edgar George Zomboss (Plants Vs. Zombies) is a Zombie Mad Scientist determined to rule the world and destroy those pesky plants once and for all.

Alex Mercer (Prototype), Mad Scientist that created a virus that absorbed him and adopted his identity.

Dr. Nefarious (Ratchet & Clank)

The Umbrella Corporation (Resident Evil) is filled with Mad Scientist Staff.

Albert Wesker (Resident Evil), Mad Scientist with a huge belief in Social Darwinism.

James Marcus (Resident Evil)

Oswell Spencer (Resident Evil)

William Birkin (Resident Evil)

Brain Drain (Skullgirls), The Mad Scientist responsible for the creation of Painwheel.

Valentine (Skullgirls), Mad Doctor and Assistant to Brain Drain. She's also very skilled at Fighting/Killing people as well.

Doctor Eggman (Sonic the Hedgehog)

Eggman Nega (Sonic the Hedgehog)

Professor Gerald Robotnik (Sonic the Hedgehog) went mad after his granddaughter's death, engineering doomsday weapons for revenge against all of humanity.

Andross (Star Fox) is a Mad Ape Scientist and the Arch-Enemy of Fox McCloud.

The Medic (Team Fortress 2) has made a lot of Unethical/Crazy Experiments including removing a patients skeleton without killing them, Reviving a guy that was dead 7 hours ago, Replacing the Heavy's heart with a Baboon one, and selling his soul along with the souls of the other mercs to the Devil.

Dr. Roy Curien (The House of the Dead), The Evil Mastermind behind the creation of several Zombies: The Chariot, The Hanged Man, The Hermit, and The Magician.

Caleb Goldman (The House of the Dead 2) was a Mad Scientist who funded Dr. Roy Curien's Research...

...and created The Emperor...

...as well as The World, who is the successor of The Emperor.

Alphys (Undertale) is a Lizard Mad Scientist who is responsible for the creation of Mettaton.

Guillaume (Vampire Night) is a Vampire Mad Scientist who was exiled by society for his Unethical/Inhumane Experiments. He has the power to transform into a winged vampire.

Dr. Crygor (WarioWare Series)

The Chemist (Zombie Night Terror) was a mad scientist who created a zombie virus. He was later killed by his own creations

Comics/Webcomics

Jyrras Gianna (Dan and Mab's Furry Adventures) is a Half Kangaroo/Kangaroo Rat Mad Scientist who likes to mix Magic/Sorcery with Science.

Bug Baron (DC Comics)

Doctor Cyclops (DC Comics)

Doctor Death (DC Comics)

Doctor Thaddeus Bodog Sivana (DC Comics), a mad scientist who is apparently able to walk through walls by using mathematical equations.

Doctor Tyme (DC Comics)

Dr. Hugo Strange (DC Comics) is a Mad Doctor/Scientist who is one of the few characters in the DC universe to know Batman's Secret Identity.

Egg Fu (DC Comics)

Ira Quimby/IQ (DC Comics)

Komrade Krabb (DC Comics)

Professor Achilles Milo (DC Comics)

Professor Ivo (DC Comics)

Rigoro Mortis (DC Comics)

T.O. Morrow (DC Comics)

Veronica Cale (DC Comics)

Dr. Germahn (El Goonish Shive)

Lord Tedd (El Goonish Shive), a black-eyed alternate universe version of Mad Scientist Tedd Verres.

Tedd Verres (El Goonish Shive)

Dr. Venom (G.I. Joe)

Agatha Clay/Heterodyne (Girl Genius), The Heroic Mad Scientist Protagonist of Girl Genius.

Members of A.I.M., Advanced Idea Mechanics, (Marvel Comics) are mad scientists that wear Beekeeper-Like Suits.

Arnim Zola (Marvel Comics) is a swiss mad scientist who transfered his mind into a robotic body and is an enemy of Captain America.

A brilliant man, Hank Pym (Marvel Comics) can be considered a mad scientist due to inventing and creating a multitude of devices, A.I.s, and discovering the famous Pym Particles.

Mister Sinister/Nathaniel Essex (Marvel Comics) is a Mad Scientist/Geneticist responsible for the creation of the Time-Traveling Mutant Cable.

The Intelligencia (Marvel Comics) is a villainous organization composed of some of the greatest Mad Scientists of the Marvel Universe.

M.O.D.O.K./Mental Organism Designed Only For Killing (Marvel Comics)

The Leader (Marvel Comics)

The Mad Thinker (Marvel Comics)

Victor Von Doom (Marvel Comics) is a mad scientist who is also one of the greatest users of prep time.

Dr. Catherine Crabtree (Sluggy Freelance)

Dr. Irving Schlock (Sluggy Freelance)

Dr. Scabmoreaueau (Sluggy Freelance), A Mad Scientist Elf who wears a Head Mirror.

Dr. Steve Hereti (Sluggy Freelance)

Riff (Sluggy Freelance)

Baxter Stockman (Teenage Mutant Ninja Turtles)

Literature

The Alchemists' Guild (Discworld)

Dr. Frankenstein (Frankenstein's Monster)

Franny K. Stein (Franny K. Stein) is a Little Girl who's mad science creates things like a two headed robot and a pumpkin monster that chews gum. Her Igor is a dog.

Dr. Impossible (Soon I Will be Invincible)

Dr. Moreau (The Island of Dr. Moreau)

Dr. Jekyll (The Strange Case of Dr. Jekyll and Mr. Hyde) created his famous split personality thanks to his mad science.

String Theory (Worm) is a mad scientist who is the poster child of a World Threatening version of one. It's stated she is capable of blowing the Moon in half.

Movies/Live Action Series

Emmett L. Brown (Back to the Future) is a crazy, not evil, mad scientist who created the DeLorean Time Machine.

Professor Zündapp (Cars 2) is a anthropomorphic 1957 Zündapp Janus who invented an EMP designed to cause Gasoline to ignite inside Cars when hit by it.

Flint Lockwood (Cloudy with a Chance of Meatballs) created the Flint Lockwood Diatonic Super Mutating Dynamic Food Replicator or FLDSMDFR for short, It's a device that turns water into any kind of food.

As a Mad Scientist, Dr. Joseph Albert Nefario (Despicable Me) works for Gru and the Minions. He creates many inventions like the Fart Gun and Cookie Bots.

Davros (Doctor Who) once tried to destroy all of reality itself due to his evil mad scientist ways.

Omega (Doctor Who) was a Time Lord Scientist who ended up isolated in a Anti-Matter Universe which made him insane. He planned to flood the main universe with Anti-Matter.

Rani (Doctor Who)

Rassilon (Doctor Who), Leader of the Time Lords and likes to mess with the universe.

The Master (Doctor Who), Mad Time Lord who is very good with science and other fields. Also a FOIL to The Doctor.

The Other (Doctor Who), one of the original founders of Time Lord Society along with Omega and Rassilon.

Shocker (Kamen Rider), A terrorist organization full of mad scientists.

Julius No (James Bond), Mad Scientist, and one of the most famous villains in the James Bond series.

Thanks to his Mad Science, Dr. Henry Wu (Jurassic Park) is responsible for the revival of many extinct animals like the T-Rex and Velociraptor.

Jumba Jookiba (Lilo & Stitch)

Dr. Isaac Taft (Lost Girl)

Megamind (Megamind) created many inventions with his Mad Science including The Spider Bot, The Brain Bots, and The De-Gun.

Dr. Cockroach (Monsters Vs. Aliens), Mad Scientist who became a Cockroach.

Shiro Ito/Dragon King (Stargirl)

Dr. Cornelius Evazan (Star Wars), a Mad Doctor/Scientist whose scientific crimes earned him twelve death sentences.

Because of his Mad Science Experiments, Seth Brundle (The Fly) became a Half-Fly Hybrid.

Syndrome (The Incredibles) created the Omnidroids, using his mad science, to kill lots of heroes.

Dr. Bunsen Honeydew (The Muppet Show), A idiotic Mad Scientist whose experiments often hurt his lab assistant Beaker.

Dr. Finkelstein (The Nightmare Before Christmas)

Herbert West (The Re-Animator)

Frank-N-Furter (The Rocky Horror Picture Show) is determined to create the perfect life form which will become his sexual plaything.

Roleplaying

Doctor Loctus Khan Schwarzwald (Anima: Beyond Fantasy)

Dr. Arkadius (Hordes) specializes in Animal Cyberization with his Mad Science. He once created an army of Cyborg Pigs for Genghis Pig-Khan.

Dr. McMourning (Malifaux) likes making Mortem Chimerism for his Mad Science, an example would be building Centaurs out of Human and Horse Corpses.

Belisarius Cawl (Warhammer 40,000) works for the Imperium of Man and is responsible for the creation of the Primaris Space Marines.

Fabius Bile (Warhammer 40,000), Mad Scientist who's aligned with Chaos.

Stormsmith Storm Towers (Warmachine) are Mad Scientists who specialize with Lightning.

Web Animation/Web Original

Dr. Bananas (Annoying Orange)

All scientists at the SCP Foundation (SCP Foundation) will become mad one time or another due to working with all the anomalies/SCPs.

Doctor Jack Bright (SCP Foundation) is one of the craziest mad scientists in the SCP Foundation.

Other

The Brotherhood of Makuta (Bionicle)

Mutran (Bionicle), one of many mad scientists that is part of the mad scientist group, The Brotherhood of Makuta.

Crazy Scientist (Lego Minifigures Series 4) certainly lives up to his name.

Monster Scientist (Lego Minifigures Series 14) is your typical cartoony mad scientist.

Izzet League (Magic: The Gathering) is an entire guild of Mad Scientists.

Niv-Mizzet (Magic: The Gathering), Leader of the Izzet League.

Jin Gitaxias (Magic: The Gathering)

Laboratory Maniac (Magic: The Gathering)

Simic Combine (Magic: The Gathering) is another Mad Scientist Guild in the Magic: The Gathering universe.

Vannifar (Magic: The Gathering) is the leader of the Simic Combine and is a Elf/Ooze Hybrid.

Using his Mad Science, Yawgmoth (Magic: The Gathering) created Plagues, Subversive Nanotech Oil, and the Bio-Mechanical Race known as the Phyrexians.

Videos

Archer Best Of Algernop Krieger FX

Dr. weird compilation (season 2)

Eggman VS Wily (Sonic VS Mega Man) DEATH BATTLE!

HOW2 How to Be a Mad Scientist!

Meet the Medic

Resident Evil Albert Wesker Explained