Archetype:Mad Scientist

Mad Scientist
Caesar Clown (One Piece), is a sadist mad scientist who creates WMDs capable of wiping out entire nations for fun and does highly unethical experiments.
The Archetype of:	Use the archetypal traits of a mad scientist.

"Tennyson, Mmhm, it seems that watch of yours is just chock-full of alien DNA and I will enjoy extracting all of it from you, as painfully as possible."

― Aloysius James Animo to Ben Tennyson as Ditto (Ben 10)

"You're weird, Morrow."

― Professor Anthony Ives to Professor Tomek Ovadya Morah/T.O. Morrow (DC Comics)

"So much has been done — more, far more, will I achieve: treading in the steps already marked, I will pioneer a new way, explore unknown powers, and unfold to the world the deepest mysteries of creation..."

― Victor Frankenstein (Frankenstein's Monster)

"Perhaps I shall dissect him once things calm down."

― Sei Kai (Kingdom)

"Ah hah hah hah! They called me mad at the university...and they were right!"

― Crazy Scientist (Lego Minifigures Series 4)

"I'm Pickle Riiick!"

― Rick Sanchez (Rick and Morty)

"You see things too simply, doctor! Expand your horizons. Life and death, sickness, and health, these are amateur terms for amateur physicians. There is only one ailment that exists in the world of men, and that is the Pestilence. And nothing else! Make no mistake, they were very ill, all of them."

― SCP-049 - Plague Doctor to Dr. Hamm (SCP Foundation)

"Call it research. Call it madness. Call it art—it's all the same to me: I must know more."

― Cornelius Evazan (Star Wars)

"I wonder if a dragon could be captured alive? It would make a fascinating test subject."

― Neloth (The Elder Scrolls)

"What the hell is that?"

"Why, it's a death ray my good man, behold."

(Fires Death Ray)

"Hey, feels warm, kinda nice."

"Well it's just a prototype, with proper funding I'm confident this little baby could destroy an area the size of New York City."

― Professor Frink chatting with Grampa Simpson (The Simpsons)

The power to use the archetypal traits of a mad scientist.

Also Called

• Mad Alchemist
• Mad Biologist/Botanist/Geologist
• Mad Chemist
• Mad Dentist/Doctor/Psychiatrist/Psychologist/Surgeon
• Mad Engineer/Gadgeteer/Genius/Inventor
• Mad Geneticist
• Mad Pharmacist
• Mad Professor
• Mad Sorcerer/Sorceress
• Mad Wizard
• Super Scientist

Properties

The user is a Mad Scientist, a scientist that dabbles in pseudoscience or perform very unethical/crazy experiments, the main reason why they are considered as "mad" or "insane" for good reason sometimes for the dangerous pursuit in attempting to play God with their science that can breaks the laws of physics/nature or to simply rule over the people who fails to recognize or value the life they treats as nothing more then subjects to prove their corrupt intelligence.

Mad scientist may be villainous (evil genius) or antagonistic, benign or neutral for good reason but some may be benevolent or good-spirited intentions, even if their actions are dangerous or questionable, which can make them accidental villains, but do have best interest at heart.

Associated Powers

• Biological Manipulation: The user can manipulate life on a cellular level, including but not limited to, genetic alterations and physical distortion and/or augmentations of biological functions. 
• Enhanced Adroitness: The user can precisely control their prehensile body parts, effectively manipulating any object, with grace, ease, strength, speed, precision, and skill.
• Enhanced Inventing/Supernatural Inventing/Absolute Inventing: Invent scientifically complex machinery, electronics, devices, gadgetry, or weaponry.
  • Pseudoscience Weaponry: The user can create weaponry capable of impossible feats and actions regardless whether they be scientifically possible or not.
• Medical Intuition: The user has great, if not innate, medical knowledge, enabling them to easily treat others' injuries and create medicines.
  • Medical/Lab Weaponry Proficiency: Users demonstrate a unique aptitude for the way of medical/lab weaponry (sutures, saws, hypodermic needle, etc...)
• Peak Human/Enhanced/Supernatural/Absolute Intelligence: The user has intelligence that is significantly above the standard genius-level intellect; possessing exceptional intellectual capabilities
• Physics Defiance: Can defy any of the laws of physics, doing things such that they could not otherwise do as if the laws of physics were not there, from ignoring energy to ignoring the laws of motion.
• Pseudoscience Manipulation: Manipulate a form of "science" that cheats the scientific method.
  • Scifi Manipulation: Manipulate the imaginary form of Science known as Science-Fiction.
    • Artificial Life Creation: Can create a variety of artificial beings for a variety of purposes, including artificial constructs, genetically engineered lifeforms, or any combination of the two.
• Science Intuition: Has extraordinary skills with the study and utilization of the field of science to produce mass inventions, conduct experimentation, and perform accurate calculations.
  • Chemical Intuition: Can intuitively understand all types and forms of chemicals and chemistry.
  • Genetics Intuition: The user possesses an incredible and innate understanding/knowledge of genetics.
  • Mechanical Intuition: The user can intuitively understand the operation of any mechanical device and subconsciously/effortlessly create a schematic in their mind.
  • Physics Intuition: The user possesses an innate understanding of physics, the branch of science concerning the functions of energy and matter.
  • Robotics Intuition: The user is intuitive in the field of robotic engineering. This includes mechanical as well as electronic engineering as they pertain to the study of robotics and/or cybernetic implementation.
  • Virology Intuition: The user is intuitive in the field of virology (the science of viruses and disease) and intuitively understand the function and behavior of viruses and can even bio-engineer new ones.
• Science Manipulation: The user can manipulate the laws of nature/science through a mundane method that manipulates reality to whatever effect they desire which can be interpreted as "super-science".
• Supernatural Surgery: The user can perform supernatural surgery, augmenting physiology/powers, and possibly even give new powers/abilities. They can treat incurable diseases/ailments and reanimate/resurrect the dead.
  • Brain Removal: The user can remove the brains (including only individual sections of the brain (the frontal lobe, motor cortex, occipital lobe, etc.) of oneself or others, usually resulting in the target's death.
  • Body Modification: The user can change and modify the bodies of oneself and others down to the genetic level, enhancing physical capabilities, modify it to be able to use certain powers, etc.
  • Body Part Substitution: The user can replace parts of their body with the same organs from outside sources, gaining the powers they'd had before the connecting, such as an eye with night vision would give the ability to see in the dark, a hand taken from a plasma blaster could allow them to fire plasma blasts from that hand.
  • Stitching: The users can cause anything on their target to be "stitched" up/together, with applications attaching things to one another, reattaching limbs, binding things to any surface, closing wounds, etc.
  • Subsuming Transplantation: The user can overlay the limbs, organs, genetic traits of others while reordering their genetic makeup for easier assimilation, eliminating the fear of organ failure and biophysical rejection from donated body parts altogether.

Variations

• Chemical Magic: The user can utilize a form of magic that involves Chemistry, allowing for harnessing their magical energies and/or mystical control of their aspects.
  • Potion Creation: The user can create potions: substances with magical properties such as enhancing physical and mental abilities, healing, granting powers, changing shape, or bewitching someone depending on the kind of potion that is made.
• Fictional Trope Physiology: The user has all the powers/abilities related to the Mad Scientist Trope or is a parody of a Mad Scientist.
• Forbidden Knowledge: The user is in possession of a dark and forbidden form of knowledge that was never meant for mortals to know. This kind of information can range from being scientific, magical, or eldritch in nature and can give the user access to abilities and capabilities far beyond human comprehension, not unlike the knowledge bestowed upon the user.
• Necromancy: The user possesses the ability to use Necromancy in experiments revolving around dead bodies.
• Science-Magic Manipulation: The user can manipulate science and magic, how they interact/go together, how compatible they are, the results of science and magic going together, from how the technology works with magic and how chemicals are altered by magic, etc.
  • Alchemy
  • Dark Alchemy

Relationships

• Archetype:Dimwitted Genius 
  • Some Mad Scientists may be dimwitted and don't make smart decisions.
• Archetype:Machiavellian
  • A mad scientist can be very charismatic, schematic, and also dangerously manipulative towards other people as a means to get ahead.
• Archetype:Psychopath
  • Usually, a mad scientist can be mentally unstable, but yet they are dangerously smart, cunning, violent, and also predatory towards their victims.

Flaws/Weaknesses

• Breach of ethics and morality leaves users vulnerable to Punishment and Karma Inducement.
  • Their own creations and experiments may rise against them.
• Vulnerable to Corrupting Madness and Madness Manipulation.

Examples Characters

See Also: Depraved Dentist, Evilutionary Biologist, Mad Doctor, Mad Scientist, Mad Scientist Laboratory, Psycho Psychologist, and Reluctant Mad Scientist.

Manhwa/Manga/Anime/Anime Movies

• Kihara Clan (A Certain Magical Index)
  • Kihara Amata
  • Kihara Gensei
• Doctor F (Alabaster)
• Dr. Fool (Astro Boy)
• Dr. Umataro Tenma (Astro Boy)
• Rasburton (Astro Boy)
• Hange Zoe (Attack On Titan)
• Huey Laforet (Baccano!)
• Renée Brinvillier (Baccano!)
• Szilard Quates (Baccano!)
• Desty Nova (Battle Angel Alita)
• Mayuri Kurotsuchi (Bleach)
• Sosuke Aizen (Bleach)
• Szayelaporro Granz (Bleach)
• Edward Hamilton/The Elder (Chrono Crusade)
• Nina Einstein (Code Geass)
• Lord Embryo (Cross Ange: Rondo of Angel and Dragon)
• Robert Schroeder (Darker Than Black)
• Rinichirō Hagire (Deadman Wonderland)
• Akihiro Kurata (Digimon Data Squad)
• Dr. Z (Dinosaur King)
• Dr. Myuu (Dragon Ball GT)
• Dr. Gero/Android 20 (Dragon Ball Z)
• Izaya Orihara (Durarara!!)
• Fran Madaraki (Franken Fran)
• Shou Tucker (Fullmetal Alchemist)
• Ryūzan Hayashi (Gintama)
• Lordgenome (Gurren Lagann)
• The Doctor (Hellsing)
• Miyo Takano (Higurashi: When They Cry)
• Tabane Shinonono (Infinite Stratos)
• Kars (JoJo's Bizarre Adventure Part II: Battle Tendency)
• Cioccolata (JoJo's Bizarre Adventure Part V/5: Golden Wind/Vento Aureo)
• Sei Kai (Kingdom)
• Dr. Moro (Kirby: Right Back at Ya!)
• Maomao (Kusuriya No Hitorigoto)
• Sucy Manbavaran (Little Witch Academia)
• Grace O'Connor (Macross Frontier)
• Bondrewd (Made in Abyss)
• Dr. Jail Scaglietti (Magical Girl Lyrical Nanoha StrikerS)
• Elicos Schenell (Mairimashita! Iruma-kun)
• Dr. Hell (Mazinger Z)
• Dr. Laughton (Metropolis)
• Tem Ray (Mobile Suit Gundam)
• Ginias Sahalin (Mobile Suit Gundam: The 08th MS Team)
• Daruma Ujiko/Kyudai Garaki (My Hero Academia)
• Kabuto Yakushi (Naruto)
• Orochimaru (Naruto)
• Caesar Clown (One Piece)
• Dr. Hogback (One Piece)
• Dr. Saruta (Phoenix)
• Dr. Weekday (Phoenix)
• Butler (Pokemon)
• Charon (Pokemon)
• Cyrus (Pokemon)
• Dr. Fuji (Pokemon)
• Dr. Namba (Pokemon)
• Dr. Yung (Pokemon)
• Dr. Zager (Pokemon)
• Professor Sebastian (Pokemon)
• Zero (Pokemon)
• Kray (Promare)
• Lucia (Promare)
• Souichi Tomoe (Sailor Moon)
• Hiroto Minaka (Sekirei)
• Dr. Ver/John Wayne Vercingetorix (Senki Zesshou Symphogear)
• Kululu (Sgt. Frog)
• Medusa (Soul Eater)
• Professor Franken Stein (Soul Eater)
• Dr. Mcfife (Speed Racer)
• Akane Shinjo (SSSS.GRIDMAN)
• Alexis • Kerib (SSSS.GRIDMAN)
• Washu Hakubi (Tenchi Muyo)
• Dr. Murkeybottom (The New Adventures of Gigantor)
• Akihiro Kanou (Tokyo Ghoul)
• Takatori Masafumi (Weiß Kreuz)
• Tsuji Mayumi (Weiß Kreuz: Glühen)
• Adelheid Von Schugel (Youjo Senki)
• Cyborg Doctor (Yu-Gi-Oh!)
• Kozaky (Yu-Gi-Oh!)
• Magical Scientist (Yu-Gi-Oh!)
• Dr. Faker (Yu-Gi-Oh! ZEXAL)
• Dr. Ichigaki (Yu Yu Hakusho)

Cartoons

• Princess Bubblegum (Adventure Time)
• Professor Pig (Angry Birds Toons)
• Dr. Weird (Aqua Teen Hunger Force)
• Frylock (Aqua Teen Hunger Force)
• Algernop Krieger (Archer)
• Aloysius James Animo (Ben 10)
• Dr. Viktor (Ben 10)
• Joseph Chadwick (Ben 10: Alien Force)
• Dr. Psychobos (Ben 10: Omniverse)
• Proctor Servantis (Ben 10: Omniverse)
• Maurice (Ben 10: Reboot)
• Di Amara (Big Hero 6: The Series)
• Obake/Bob Aken (Big Hero 6: The Series)
• Chameleon (Birdman and the Galaxy Trio)
• Doctor Shado/The Brain Thief (Birdman and the Galaxy Trio)
• Doctor Shark (Birdman and the Galaxy Trio)
• Dr. Freezoid (Birdman and the Galaxy Trio)
• Dr. Mentaur (Birdman and the Galaxy Trio)
• Dr. Millennium (Birdman and the Galaxy Trio)
• Metallo (Birdman and the Galaxy Trio)
• Morto the Maruader (Birdman and the Galaxy Trio)
• Nitron the Human Bomb (Birdman and the Galaxy Trio)
• Professor Klaw (Birdman and the Galaxy Trio)
• Professor Nightshade (Birdman and the Galaxy Trio)
• Reducto (Birdman and the Galaxy Trio)
• Vulturo (Birdman and the Galaxy Trio)
• Dr. Blood (Bolts and Blip)
• Doctor Blight (Captain Planet and the Planeteers)
• Professor Thurdigree Burns (Casper's Scare School)
• Ulmar (Chaotic)
• Professor Norton Nimnul (Chip 'N Dale Rescue Rangers)
• Chester (Codename: Kids Next Door)
• Professor Bob (Codename: Kids Next Door)
• Professor XXXL (Codename: Kids Next Door)
• Doctor Von Goosewing (Count Duckula)
• Di Lung (Courage the Cowardly Dog)
• Dr. Gerbil (Courage the Cowardly Dog)
• Dr. Zalost (Courage the Cowardly Dog)
• The Cruel Vet (Courage the Cowardly Dog)
• Vlad Plasmius (Danny Phantom)
• Dexter (Dexter's Laboratory)
• Mandark (Dexter's Laboratory)
• Victor Veloci (DinoSquad)
• Mechanicles (Disney's Aladdin)
• Major Doctor Ghastly (Evil Con Carne)
• Stewie Griffin (Family Guy)
• The Professor/Professor Nutty Nut-Meg (Felix the Cat)
• Dr. Dirk Spamflex (Fleabag Monkeyface)
• Hubert Farnsworth (Futurama)
• Van Kleiss (Generator Rex)
• Old Man McGucket (Gravity Falls)
• Dr. Claw (Inspector Gadget)
• Dr. Focus (Inspector Gadget)
• Professor Membrane (Invader Zim)
• Zim (Invader Zim)
• Dr. Ashida (Jonny Quest)
• Dr. Chu Sing Ling (Jonny Quest)
• Dr. Zin (Jonny Quest)
• Olaf (Kaeloo)
• Dr. Drakken (Kim Possible)
• Professor Dementor (Kim Possible)
• Dr. Emilia (Kipo and the Age of Wonderbeasts)
• Awful Alvin (Larryboy: The Cartoon Adventures)
• Greta Von Gruesome (Larryboy: The Cartoon Adventures)
• The Alchemist/Edward "Cubby" Wiggins (Larryboy: The Cartoon Adventures)
• Doktor Frogg (League of Super Evil)
• Dr. Jekyll (Looney Tunes)
• Mad Scientist (Looney Tunes/Hair Raising Hare)
• Mad Scientist (Looney Tunes/Water, Water Every Hare)
• Camille (Mao Mao: Heroes of Pure Heart)
• Alien Scientist (Max Steel)
• Professor Mortum (Max Steel)
• Terrorax/Dr. Prometheus Halifax (Max Steel)
• Toxzon/Tytus Octavius Xander (Max Steel)
• Ludwig Von Drake (Mickey & Friends)
• Miranda Bell (Monster by Mistake)
• Dr. Cutter (Monsters vs. Aliens TV Series)
• Dr. Locus (My Life as a Teenage Robot)
• Lord Boxman (OK K.O.! Let's Be Heroes)
• Heinz Doofenshmirtz (Phineas and Ferb)
• Brain (Pinky and the Brain)
• Mad Mueller (Popeye the Sailor)
• Willem Viceroy III (Randy Cunningham: 9th Grade Ninja)
• Rick Sanchez (Rick & Morty)
• Entrapta (She-Ra and the Princesses of Power)
• Dr. Quintin Kalowski (Slugterra)
• Dr. Thaddius Blakk (Slugterra)
• The Game Master (Slugterra)
• Gargamel (Smurfs)
• Dr. Alphonse Mephesto (South Park)
• Sheldon J. Plankton (Spongebob Squarepants)
• Nuvo Vindi (Star Wars: The Clone Wars)
• Dr. Elrod Purvis/Dr.Viper (SWAT Kats: The Radical Squadron)
• The Rat King/Victor Falco (Teenage Mutant Ninja Turtles 2012 TV Series)
• Victor Frankenstein (Teenage Mutant Ninja Turtles 2012 TV Series)
• Professor Chang (Teen Titans)
• Jimmy Neutron (The Adventures of Jimmy Neutron, Boy Genius)
• Viktor (The All-New Popeye Hour)
• Nathan (The Garfield Show)
• Professor "Thaddeus" Bonkers (The Garfield Show)
• Dr. Fruitenstein (The High Fructose Adventures of Annoying Orange)
• Lisa Loud (The Loud House)
• Mito (The New Adventures of Nanoboy)
• Dr. Blowhole (The Penguins of Madagascar)
• Mojo Jojo (The Powerpuff Girls)
• Angus (The Secret Files of Spy Dogs)
• Professor Frink (The Simpsons)
• Dr. Otto (The Tom and Jerry Show)
• Jonas Venture Sr. (The Venture Bros.)
• Glowface (The X's)
• Mad Scientist (Tom and Jerry)
• Candy Sweet (Totally Spies)
• Captain Hayes (Totally Spies)
• Coffee Guy (Totally Spies)
• Cosmo Stratus (Totally Spies)
• Diminitive Smalls (Totally Spies)
• Dr. Gelee (Totally Spies)
• Dr. Inga Bittersweet (Totally Spies)
• Inventor (Totally Spies)
• Max Exterminatus (Totally Spies)
• Bird Brain (T.U.F.F. Puppy)
• Dean Cuizeen (Turbo Fast)
• Dr. Fox (Unikitty!)
• Dr. Flug Slys (Villainous)
• Nox/Noximilien Coxen (Wakfu)
• Qilby (Wakfu)
• Zachary "Zach" Varmitech (Wild Kratts)
• Dr. Two-Brains (Wordgirl)
• Dr. Stankfoot/Stanley K. Foot (Zevo-3)

Comics/Web Comics

• Louis Reine (Aliens: Earth Hive)
• Stan Mayakovsky (Aliens: Harvest)
• Paul Church (Aliens: Labyrinth)
• Thomas Spears (Aliens: Nightmare Asylum)
• Waidslaw Orona (Aliens: Outbreak)
• Ernst Kleist (Aliens: Rogue)
• Caspar Nordling (Aliens: Stronghold)
• Dr. Dinosaur (Atomic Robo)
• Doktor Sleepless/John Reinhardt (Avatar Press)
• Doctors/Hospital Staff (Awful Hospital: Seriously the Worst Ever)
  • Dr. Circula Tori
  • Dr. Dementist
  • Dr. Dinea
  • Dr. Everton Morteus Balmer
  • Dr. Gynnie Specula
  • Dr. H. M. Phage, T. E.
  • Dr. Ichabod Malachi Man
  • Dr. Magdolene
  • Dr. Phineas Fleagood
  • Dr. Phleboto Mizer
  • Dr. Rory Shock
  • Dr. Ucy
  • Molly Curdle
• Dr. Everton Morteus Balmer (Awful Hospital: Seriously the Worst Ever)
• Ghastly Physician Worm (Awful Hospital: Seriously the Worst Ever)
• Unnecessary Surgery Worm (Awful Hospital: Seriously the Worst Ever)
• Catherine Fortune (Batman/Aliens II)
• Casey and Andy (Casey and Andy)
• Dr. Leonard Price (Chaos! Comics)
• Jyrras Gianna (Dan and Mab's Furry Adventures)
• Blockbuster/Mark Desmond (DC Comics)
• Brain (DC Comics)
• Brainiac (DC Comics)
• Bug Baron (DC Comics)
• Doctor Cyclops (DC Comics)
• Doctor Death (DC Comics)
• Doctor Thaddeus Sivana (DC Comics)
• Doctor Tyme (DC Comics)
• Doctor William Magnus (DC Comics)
• Dr. Hugo Strange (DC Comics)
• Egg Fu (DC Comics)
• Floronic Man (DC Comics)
• IQ/Ira Quimby/ (DC Comics)
• Jax-Ur (DC Comics)
• Komrade Krabb (DC Comics)
• Krona (DC Comics)
• Lex Luthor (DC Comics)
• Mad Hatter (DC Comics)
• Man-Bat (DC Comics)
• Mr. Freeze (DC Comics)
• Poison Ivy/Pamela Isley (DC Comics)
• Professor Achilles Milo (DC Comics)
• Professor Ivo (DC Comics)
• Professor Pyg (DC Comics)
• Riddler (DC Comics)
• Rigoro Mortis (DC Comics)
• Riot (DC Comics)
• Robert Quinlan (DC Comics)
• Scarecrow (DC Comics)
• T.O. Morrow (DC Comics)
• Ultra-Humanite (DC Comics)
• Veronica Cale (DC Comics)
• Zookeeper (DC Comics)
• Dr. Germahn (El Goonish Shive)
• Lord Tedd (El Goonish Shive)
• Tedd Verres (El Goonish Shive)
• Dr. Mindbender (G.I. Joe)
• Dr. Venom (G.I. Joe)
• Sparks (Girl Genius)
  • Agatha Clay/Heterodyne
  • Gilgamesh Wulfenbach
• Zio Boris (Horror)
• Abraham Cornelius (Marvel Comics)
• Members of AIM (Advanced Idea Mechanics) (Marvel Comics)
• Aliana Alba (Marvel Comics)
• Alistair Alphonso Smythe (Marvel Comics)
• Arnim Zola (Marvel Comics)
• Baron Heinrich Zemo (Marvel Comics)
• Bolivar Trask (Marvel Comics)
• Dale Rice (Marvel Comics)
• David Moreau (Marvel Comics)
• Doctor Faustus/Johann Fennhoff (Marvel Comics)
• Doctor Octopus (Marvel Comics)
• Dr. Steven Lang (Marvel Comics)
• Egghead (Marvel Comics)
• Hank Pym (Marvel Comics)
• High Evolutionary (Marvel Comics)
• Horst Gorscht (Marvel Comics)
• Lady Octopus (Marvel Comics)
• Lyle Dekker (Marvel Comics)
• Machinesmith (Marvel Comics)
• Martin Sutter (Marvel Comics)
• Mister Hyde (Marvel Comics)
• Mister Sinister/Nathaniel Essex (Marvel Comics)
• Mole Man (Marvel Comics)
• Norman Osborn (Marvel Comics)
• Red Skull/Johann Schmidt (Marvel Comics)
• Robert Chandler (Marvel Comics)
• Spencer Smythe (Marvel Comics)
• Stegron (Marvel Comics)
• Superia/Deidre Wentworth (Marvel Comics)
• The Intelligencia (Marvel Comics)
  • M.O.D.O.K./Mental Organism Designed Only For Killing
  • The Leader
  • The Mad Thinker
• The Lizard/Curt Connors (Marvel Comics)
• Truett Hudson (Marvel Comics)
• Ultron (Marvel Comics)
• Victor Von Doom (Marvel Comics)
• William Taurey (Marvel Comics)
• Zander Rice (Marvel Comics)
• Doctor Niels Reinstöt (Predator vs. Judge Dredd vs. Aliens: Splice and Dice)
• Doc Krok (Sardine in Outer Space)
• Dr. Catherine Crabtree (Sluggy Freelance)
• Dr. Irving Schlock (Sluggy Freelance)
• Dr. Scabmoreaueau (Sluggy Freelance)
• Dr. Steve Hereti (Sluggy Freelance)
• Riff (Sluggy Freelance)
• Baxter Stockman (Teenage Mutant Ninja Turtles)
• Dr Lewis W. Breign (The Snail Factory)
• Doctor Terminal (The Umbrella Academy)

Live Television/Movies

• Dr. Wolfowitz (3 Pigs and a Baby)
• Ash (Alien)
• Jonathan Gediman (Alien Ressurection)
• Mason Wren (Alien Ressurection)
• Gaetan "Mole" Moliére (Atlantis: The Lost Empire)
• Dr. Evil (Austin Powers)
• Dr. Cordell Lovecraft (Avatar)
• Emmett L. Brown (Back to the Future)
• Honey Lemon (Big Hero 6)
• Dr. Howard Vanard (Blood of Ghastly Horror)
• Doctor Septimus Pretorius (Bride of Frankenstein)
• Professor Zündapp (Cars 2)
• Flint Lockwood (Cloudy with a Chance of Meatballs)
• Dr. Joseph Albert Nefario (Despicable Me)
• Davros (Doctor Who)
• Omega (Doctor Who)
• Rani (Doctor Who)
• Rassilon (Doctor Who)
• Richard Lazarus (Doctor Who)
• The Doctor (Doctor Who)
• The Master (Doctor Who)
• Dr. Horrible (Dr. Horrible's Sing-Along Blog)
• Dr. Strangelove/Merkwürdigliebe (Dr. Strangelove)
• Dr. Preturius (Felidae)
• Dr. Hans Zarkov (Flash Gordon)
• Victor Frankenstein (Frankenweenie)
• Dr. William Bell (Fringe)
• Walter Bishop (Fringe)
• Dr. Edward Pretorius (From Beyond)
• Dr. Daisuke Serizawa (Godzilla Series)
• Dr. Shinzo Mafune (Godzilla Series)
• Genshiro Shiragami (Godzilla Series)
• Dr. Phillip Channard (Hellbound: Hellraiser II)
• Mohinder Suresh (Heroes)
• Dr. Glickenstein (Igor)
• Dr. Schadenfreude (Igor)
• Ernst Stavo Blofled (James Bond)
• Hugo Drax (James Bond)
• Julius No (James Bond)
• Henry Wu (Jurassic Park)
• Members of Shocker (Kamen Rider)
• Doctor Gao (Lab Rats)
• Donald Davenport (Lab Rats)
• Douglas Davenport (Lab Rats)
• Jumba Jookiba (Lilo & Stitch)
• Isaac Taft (Lost Girl)
• Darren Cross (Marvel Cinematic Universe)
• Leopold James Fitz (Marvel Cinematic Universe)
• Megamind (Megamind)
• Doctor Frankenollie (Mickey Mouse: Runaway Brain)
• Dr. Cockroach (Monsters Vs. Aliens)
• Dr. Clayton Deborah Susan Forrester (Mystery Science Theater 3000)
• Pearl Forrester (Mystery Science Theater 3000)
• Agent Oscar (Odd Squad)
• Agent Oona (Odd Squad)
• Dave (Penguins of Madagascar: The Movie)
• Professor Kipple (Planet 51)
• David (Prometheus)
• Dragon King/Shiro Ito (Stargirl)
• Cornelius Evazan (Star Wars)
• Dr. DeMarco (The Astro-Zombies)
• Skektek the Scientist (The Dark Crystal Series)
• Yzma (The Emperor's New Groove)
• Andre Delambre (The Fly (1958) )
• Seth Brundle (The Fly (1986) )
• Anton Bartok (The Fly II)
• Syndrome (The Incredibles)
• Dr. Janos Rukh (The Invisible Ray)
• Dr. Shrinker (The Krofft Supershow)
• Dr. Faust (The Last Faust)
• Dr. Bunsen Honeydew (The Muppet Show)
• Dr. Finkelstein (The Nightmare Before Christmas)
• The Nutty Professor (The Nutty Professor)
• Dan Cain (The Re-Animator)
• Dr. Carl Hill (The Re-Animator)
• Dr. Hans Gruber (The Re-Animator)
• Herbert West (The Re-Animator)
• Professor Waldo Cunningham (The Return of Captain Nemo)
• Frank-N-Furter (The Rocky Horror Picture Show)
• Dr. Miguelito Quixote Loveless (The Wild Wild West)
• Dr. Frederick Frankenstein (The Young Frankenstein)
• Dr. Professor (Tom and Jerry: The Fast and the Furry)
• Robert Ford (Westworld)
• Colonel William "Bill" Stryker Jr. (X2: X-Men United)

Literature/Magazines

• Captain Nemo (20,000 Leagues Under the Sea)
• Abdul-Aziz al-Rahim (Alex Rider)
• Bill Tanner (Alex Rider)
• Dr. Hugo Grief (Alex Rider)
• Dr. Three (Alex Rider)
• Leonard Straik (Alex Rider)
• Myra Bennett (Alex Rider)
• Blue Marsalis (Alien: The Cold Forge)
• Professor Cezar Kouska (A Perfect Vacuum)
• Professor James Dobbs (A Perfect Vacuum)
• Opal Koboi (Artemis Fowl Series)
• Qyburn (A Song of Ice and Fire)
• Dr. Phillip K. Decker (Cabal)
• Tippy Tinkletrousers/Professor Pippy P. Poopypants (Captain Underpants)
• Mad Scientists (City of Devils)
• The Alchemists' Guild (Discworld)
• Doctor Death (Doctor Death)
• Morlock (Doctor Who Prose)
• The Other (Doctor Who Prose)
• Dr. Mabuse (Dr. Mabuse, the Gambler)
• Dr. Ox (Dr. Ox's Experiment)
• Physicist Molteris (Fizyk Molteris)
• Dr. Frankenstein (Frankenstein’s Monster)
• Franny K. Stein (Franny K. Stein)
• Dr. Crawford Tillinghast (From Beyond (Book Version) )
• Faust (German Folklore)
• Professor Farragus (Koniec świata o ósmej)
• Professor Clarissa Garrity (Laughter at the Academy)
• Otto Hantzen (Les Mystères de Demain)
• Ammon Lymphater (Lymphater's Formula)
• Jeremiasz Tichy (Memoirs of a Space Traveler/The Star Diaries)
• Doctor Vliperdius (Memoirs of a Space Traveler/The Star Diaries)
• Professor Corcoran (Memoirs of a Space Traveler/The Star Diaries)
• Professor Decantor (Memoirs of a Space Traveler/The Star Diaries)
• Professor Diagoras (Memoirs of a Space Traveler/The Star Diaries)
• C. A. Rotwang (Metropolis)
• Dr. Jigsaw (N.E.R.D.S.: National Espionage, Rescue, and Defense Society)
• Professor A.Dońda (Professor A.Dońda)
• Professor Zazul (Professor Zazul)
• Dr. Stinky McNasty (Ricky Ricotta's Mighty Robot)
• Mr. Mosquito (Ricky Ricotta's Mighty Robot)
• Victor Von Vulture (Ricky Ricotta's Mighty Robot)
• Major Monkey (Ricky Ricotta's Mighty Robot)
• General Jackrabbit (Ricky Ricotta's Mighty Robot)
• Sergeant Stinkbug (Ricky Ricotta's Mighty Robot)
• Uncle Unicorn (Ricky Ricotta's Mighty Robot)
• Nimrod Nightcrawler (Ricky Ricotta's Mighty Robot)
• President Penguin (Ricky Ricotta's Mighty Robot)
• Dr. Impossible (Soon I Will Be Invincible)
• Bevel Lemelisk (Star Wars Legends)
• Sith Alchemists (Star Wars Legends)
  • Belia Darzu
  • Naga Sadow
• Madame Olivier (The Big Four)
• Dr. Josef Mengele (The Boys From Brazil)
• Griffin (The Invisible Man)
• Dr. Moreau (The Island of Doctor Moreau)
• The Master (The Master: An Adventure Story)
• Ras Thavas (The Master Mind of Mars)
• Dr. Jekyll (The Strange Case of Dr. jekyll and Mr. Hyde)
• De Selby (The Third Policeman)
• Belphegor (Whateley Academy)
• Jobe Ann Wilkins (Whateley Academy)
• Mega-Death (Whateley Academy)
• Overclock (Whateley Academy)
• String Theory (Worm)

Music Videos

• Mad Scientist (They Might Be Giants - I Am Invisible)

RPGs/Trading Card Games

• Dr. Loctus Khan Schwarzwald (Anima: Beyond Fantasy)
• Gandolfo (Dungeons and Dragons)
• Nadul DaRoni (Forgotten Realms/Dungeons and Dragons)
• Tinkersdam of Gond (Forgotten Realms/Dungeons and Dragons)
• Dr. Arkadius (Hordes)
• Izzet League (Magic: The Gathering)
  • Niv-Mizzet
• Jin Gitaxias (Magic: The Gathering)
• Laboratory Maniac (Magic: The Gathering)
• Simic Combine (Magic: The Gathering)
  • Vannifar
• Yawgmoth (Magic: The Gathering)
• Dr. McMourning (Malifaux)
• Doctor DeathBreath (Super Munchkin/Munchkin series)
• Belisarius Cawl (Warhammer 40,000)
• Fabius Bile (Warhammer 40,000)
• Stormsmith Storm Towers (Warmachine)

Video Games

• Professor Brains (Age of Zombies)
• David Hale (Aliens: Colonial Marines)
• Steven Hale (Aliens: Colonial Marines)
• Friel (Aliens: Genocide)
• Arnaud Eisenberg (Aliens versus Predator 2)
• Samuel Kadinsky (Aliens versus Predator: Extinction)
• H. G. Groves (Aliens vs. Predator)
• Karl Bishop Weyland (Aliens vs. Predator)
• Dr. Coyle (ARMS)
• Klungo (Banjo-Kazooie)
• Alice Angel (Bendy and the Ink Machine)
• Yi Suchong (BioShock)
• Kokonoe Mercury (Blazblue)
• Relius Clover (Blazblue)
• Dr. Ned (Borderlands)
• Dr. Zed (Borderlands)
• Gaige (Borderlands 2)
• Handsome Jack (Borderlands 2)
• Professor Nakayama (Borderlands 2)
• Oletta (Borderlands 3)
• Doctor Spara (Borderlands: The Pre-Sequel)
• Clown Surgeons (CarnEvil)
• Ludwig von Tökkentäkker (CarnEvil)
• Dr. Thrax (Command and Conquer: Generals)
• Professor von Kriplespac (Conker's Bad Fur Day/Conker: Live & Reloaded)
• Dr. Nefarious Tropy (Crash Bandicoot Series)
• Dr. Neo Cortex (Crash Bandicoot Series)
• Dr. N. Gin (Crash Bandicoot Series)
• Dr. Nitrus Brio (Crash Bandicoot Series)
• Scientists (Critter Escape)
• Dr. Kahl (Cuphead)
• The Scientist (Dark Escape 4D)
• Herman Carter (Dead by Daylight)
• Talbot Grimes (Dead by Daylight)
• Victor Donovan (Dead or Alive)
• Albert Contiello (Dead Rising 3)
• Dr. Mayhem (Defenders of Dynatron City)
• Orthropox (Destroy All Humans)
• Bob Page (Deus Ex)
• Dr. Andonuts (Earthbound)
• Mad Doctor (Epic Mickey Series)
• The Master (Fallout)
• Dr. Stanislaus Braun (Fallout 3)
• Professor Calvert (Fallout 3)
• The Think Tanks (Fallout: New Vegas)
• Doctor Lugae (Final Fantasy IV)
• Kefka Palazzo (Final Fantasy VI)
• Professor Hojo (Final Fantasy VII)
• William Afton (Five Nights at Freddy's series)
• Dr. Rachel Claudius (God Eater 2)
• Dr. Labrat (Grand Theft Auto 2)
• Faust/Dr. Baldhead (Guilty Gear Series)
• Members of Aperture Science (Half-Life/Portal)
• Kevin Clamely/Patriarch (Killing Floor)
• Hans Volter (Killing Floor 2)
• Vexen (Kingdom Hearts)
• Xehanort (Kingdom Hearts)
• Heimerdinger (League of Legends)
• Professor Von Yipp (Legends of Runeterra)
• Skeleton Mad Scientist (Lego Universe)
• Professor E. Gadd (Luigi's Mansion)
• Fawful (Mario & Luigi Series)
• Henry Lawson (Mass Effect)
• Doctor Albert W. Wily (Mega Man)
• Dr. Weil (Mega Man Zero)
• Amadeus Syndicate (Metal Slug 4/Attack)
  • Alma
  • Doctor
  • Scientists
• Franke (Metal Slug Attack)
• Percier (Metal Slug Attack)
• Professor (Metal Slug Attack)
• Navy (Metal Slug Attack)
• Quan Chi (Mortal Kombat)
• Shang Tsung (Mortal Kombat)
• Dr. Manhole (Mr. Driller Series)
• Scientists (New Blood Interactive's DUSK)
• Moira (Overwatch)
• Sigma (Overwatch)
• Crazy Dave (Plants Vs. Zombies)
• Dr. Edgar George Zomboss (Plants Vs. Zombies)
• Dr. Hare (Poptropica)
• Alex Mercer (Prototype)
• Dr. Anton Koenig (Prototype)
• Raymond McMullen (Prototype)
• Dr. Loboto (Psychonauts)
• Dr. Nefarious (Ratchet & Clank)
• Umbrella Corp. staff (Resident Evil)
  • Albert Wesker
  • Alexia Ashford
  • James Marcus
  • Oswell Spencer
  • William Birkin
• Dr. Merlot (RWBY: Grimm Eclipse)
• Dr. Jekyll (Scribblenaut Series)
• Mad Scientist (Scribblenaut Series)
• Elexis Sinclaire (SiN Series)
• Brain Drain (Skullgirls)
• Valentine (Skullgirls)
• Dr. Krankcase (Skylanders)
• Pop Fizz (Skylanders)
• Dr. M (Sly Cooper)
• Doctor Eggman (Sonic the Hedgehog)
• Eggman Nega (Sonic the Hedgehog)
• Gerald Robotnik (Sonic the Hedgehog)
• Egon Stetmann (Starcraft)
• Andross (Star Fox)
• Rintaro Okabe (Steins;Gate)
• Dr. Fetus (Super Meat Boy)
• Furst (Taimanin Asagi)
• Engineer (Team Fortress 2)
• Medic (Team Fortress 2)
• Dr. Bosconovitch (Tekken)
• Neloth (The Elder Scrolls)
• Dr. Roy Curien (The House of the Dead)
• Caleb Goldman (The House of the Dead 2)
• Alphys (Undertale)
• Mad Scientist (Valkyrie Crusade)
• Guillaume (Vampire Night)
• Monaca Towa (Danganronpa Another Episode: Ultra Despair Girls)
• Dr. Crygor (WarioWare Series)
• Oberst-Gruppenführer Wilhelm Strasse (Wolfenstein)
• Dr. Schabbs (Wolfenstein 3D)
• Mad Scientists (World of Warcraft)
  • Apothecary Frye
  • Chief Plaguebringer Middleton
  • Doctor Gutrick
  • Doctor Ickus
  • Doctor Maleficus
  • Doctor Razorgrin
  • Doctor Sabnok
  • Doctor Sintar Malefious
  • Dr. Terrible
  • Dr. Whitherlimb
  • Forsaken Blightspreader
  • Forsaken Plaguesmith
  • Mad Scientist
  • Plaguebringer Tillinghast
  • Professor Putricide
  • Professor Slate
  • Scourge Technician
  • Surgeon Stitchflesh
  • Warden Stillwater
• The Chemist (Zombie Night Terror)

Web Animation/Original/Series

• Dr. Bananas (Annoying Orange)
• Katz (Monster Lab)
• Dr. Emily Gray (Red vs. Blue)
• SCP-049-The Plague Doctor (SCP Foundation)
• SCP-1760-Casket Garden/Pyotr (SCP Foundation)
• Scientists of the SCP Foundation (SCP Foundation)
  • Doctor Jack Bright
• Doc Rex (Screaming Soup!)
• Dr. Rig R. Mortis MD (Screaming Soup!)
• Baxter (The Hazbin Hotel)
• Dr. Cochram Block (The Nostalgia Chick/Channel Awesome)
• Dr. Coquette Tease (The Nostalgia Chick/Channel Awesome)
• Dr. Insano (The Spoony Experiment/Channel Awesome)
• Linksano (The Spoony Experiment/Channel Awesome)

Other

• The Brotherhood of Makuta (Bionicle)
  • Mutran
• Dr. D. Zaster (Lego Agents)
• Dr. Inferno (Lego Agents)
• Ogel (Lego Alpha Team)
• Crazy Scientist (Lego Minifigures Series 4)
• Mr. Good and Evil (Lego Minifigures Series 9)
• Monster Scientist (Lego Minifigures Series 14)
• The Crazy Scientist (Lego Monster Fighters)

Gallery

Anime/Manga/Manhwa

Kihara Amata (A Certain Magical Index), The Mad Scientist responsible for helping train Accelerator to use his Vector Manipulation.

Kihara Gensei (A Certain Magical Index) is a mad scientist and is obsessed with the creation of level 6 as well as the one responsible for the Level 6 Shift attempt on Misaka Mikoto.

Dr. Fooler (Astro Boy)

Dr. Umataro Tenma (Astro Boy), The Mad Scientist who created Astro Boy and slowly drove to madness.

Hange Zoe (Attack on Titan) is a rare example of a Heroic Mad Scientist.

Huey Laforet (Baccano!)

Renée Brinvillier (Baccano!)

Szilard Quates (Baccano!) is an evil Mad Scientist or in this case Alchemist.

Desty Nova (Battle Angel Alita)

Mayuri Kurotsuchi (Bleach) is one of Soul Society's greatest scientists, though most of that is due to his lack of ethics and morality.

Sosuke Aizen (Bleach) is unusual for a Mad Scientist in that he likes it when his creations do something unexpected rather than the creations doing what he expects.

Szayelaporro Granz (Bleach) is a brilliant Arrancar scientist and represents the aspect of "madness" amongst the Espada.

Edward Hamilton (Chrono Crusade), A mild but still crazy Mad Scientist.

Nina Einstein (Code Geass)

Lord Embryo (Cross Ange: Rondo of Angel and Dragon) wants to destroy the world of Mana and remake it in his own image/taste. He is responsible for remaking the genetic makeup of humanity in the Cross Ange Universe.

Robert Schroeder (Darker Than Black)

Rinichirō Hagire (Deadman Wonderland)

Akihiro Kurata (Digimon Data Squad) is a villainous Mad Scientist who fused with a Demon Lord and created an army of Artificial Digimon in order to wipe out all Digimon. He also created Space-Time Bombs that created a tear in Reality.

Dr. Z (Dinosaur King)

Doctor Myuu (Dragon Ball GT)

Doctor Gero/Android 20 (Dragon Ball Z) was a mad scientist who created Androids in his attempt for world domination, revenge, and genocide.

Izaya Orihara (Durarara!!)

Fran Madaraki (Franken Fran), Mad Scientist who also has a lot of body horror.

Shou Tucker (Fullmetal Alchemist), A Mad Alchemist who combined his own daughter and Dog into a Chimera.

Ryūzan Hayashi (Gintama) was a scientist who developed the method to transcribe the human mind as data, a forbidden technique.

Lordgenome (Gurren Lagann), Creator of the Beastmen.

The Doctor (Hellsing), The German Mad scientist working for the Millennium Forces.

Miyo Takano (Higurashi: When They Cry)

Tabane Shinonono (Infinite Stratos) , creator of the Infinite Stratos (IS) Suits. These suits changed the nature of warfare and the power dynamics between gender.

Dissatisfied with his people's way of life and consumed by ambition, Kars (JoJo's Bizarre Adventure Part II: Battle Tendency) created the Stone Masks and began to test their effects on himself as he began to seek a way for his race to "tame the sun" and leave the underground...

...after experimenting with the effects of the masks on himself, he gained increased manipulation of his body at the cost of greatly increased hunger.

Cioccolata (JoJo's Bizarre Adventure Part V/5: Golden Wind/Vento Aureo)

Sei Kai (Kingdom)

Using his Mad Science, Dr. Moro (Kirby: Right Back at Ya!) created dinosaur hybrids including a Kirby one.

Though more of a Mad Pharmacist than a scientist, Maomao (Kusuriya No Hitorigoto) loves to experiment on herself with Animal Venoms, Deadly Poisons, and Dangerous Chemicals in order to feel their effect.

Sucy Manbavaran (Little Witch Academia) is the Fantasy/Magical World equivalent of a Mad Scientist. She often comes up with new Potions and Poisons to experiment on unsuspecting people.

Grace O'Connor (Macross Frontier)

Bondrewd (Made in Abyss)

Jail Scaglietti (Magical Girl Lyrical Nanoha Strikers)

Elicos Schenell (Mairimashita! Iruma-Kun)

Dr. Hell (Mazinger Z)

Dr. Laughton (Metropolis) is a classic example of a mad scientist.

Tem Ray (Mobile Suit Gundam), Father of Amuro, became a mad scientist after suffering oxygen deprivation which resulted in damage to his brain.

Daruma Ujiko/Kyudai Garaki (My Hero Academia) is responsible for creating Nomus: Monsters made from altered corpses that are able to use multiple powers. He's also a faithful servant of both All For One and Tomura Shigaraki.

Ginias Sahalin (Mobile Suit Gundam: The 08th MS Team)

Kabuto Yakushi (Naruto) sought to create his forgotten identity that he experimented with corpses and humans alike...

...eventually turning to place those tests onto his own body.

Orochimaru (Naruto), A Snake-Like Mad Scientist who has done plenty of genetics.

Dr. Hogback (One Piece), More of a Mad Doctor than a Scientist but does a lot of unethical experiments.

Dr. Saruta (Phoenix)

Butler's (Pokemon) Mad Scientist experiment involved using Jirachi as a power source.

Charon (Pokémon), Mad Scientist who works for Team Galactic and their plans to reshape reality.

Cyrus (Pokemon), Mad Scientist and Nihilist who wants to destroy the universe and remake it in his own image.

Dr. Fuji (Pokémon), Mad Scientist responsible for creating Mewtwo.

Dr. Namba (Team Rocket) is the craziest mad scientist in the Team Rocket Organization, Building lots of Ridiculous Inventions to capture Pokemon. He also gets triggered/angered whenever someone mispronounces his name.

Dr. Yung (Pokemon) planned to take over the world by using super-powerful pokemon holograms.

Dr. Zager (Pokemon), Monocle sporting Mad Scientist who works with Team Rocket.

Professor Sebastian (Pokemon) uses his Mad Science to mess with Radio Waves, His goal being to use these Radio Waves to force Pokemon to evolve or lure them.

Zero (Pokemon) is a Mad Scientist who's also a Yandere.

Kray (Promare)

Lucia (Promare)

Souichi Tomoe (Sailor Moon), Mad Scientist, and enemy to the Sailor Scouts.

Hiroto Minaka (Sekirei)

Dr. Ver/John Wayne Vercingetorix (Senki Zesshou Symphogear) is a Mad Scientist who's specialty is Relic Research.

Kululu (Sgt. Frog) is not only a Mad Scientist but also a Witch Doctor.

Medusa (Soul Eater), Creator of Crona.

Professor Franken Stein (Soul Eater)

Dr. Mcfife (Speed Racer) once created a car controlled by a computer.

Akane Shinjo (SSSS.GRIDMAN)

Alexis • Kerib (SSSS.GRIDMAN)

Washu Hakubi (Tenchi Muyo), Who created a Daughter using DNA Splicing, Which used her own DNA and the DNA of a Life Form known as Mass. She also owns a private laboratory that covers hundreds of planets.

Akihiro Kanou (Tokyo Ghoul)

Takatori Masafumi (Weiß Kreuz)

Tsuji Mayumi (Weiß Kreuz: Glühen)

Adelheid Von Schugel (Youjo Senki)

Cyborg Doctor (Yu-Gi-Oh!)

Kozaky (Yu-Gi-Oh!)

Magical Scientist (Yu-Gi-Oh!)

Dr. Faker (Yu-Gi-Oh! ZEXAL) who did everything to keep his son Haruto alive.

Dr. Ichigaki (Yu Yu Hakusho)

Cartoons

Princess Bubblegum (Adventure Time)

Professor Pig (Angry Birds Toons) is a Mad Scientist pig who enjoys making peaceful inventions. He is also one of the few pigs who is friends with the birds.

Dr. Weird (Aqua Teen Hunger Force)

Frylock (Aqua Teen Hunger Force), A Mad Scientist who is a living box of French Fries.

Algernop Krieger (Archer) is a mad scientist who once used the psychotropic drug Scopolamine.

Aloysius James Animo (Ben 10) is a Mad scientist who likes creating mutated animals/aliens.

Dr. Viktor (Ben 10) is a Transylian Mad Scientist who resurrected his Ectonurite Master Zs'Skayr.

Joseph Chadwick (Ben 10: Alien Force) is a mad scientist working for the Forever Knights.

Dr. Psychobos (Ben 10: Omniverse) is a Cerebrocrustacean Mad Scientist who created the Nemetrix, A Omnitrix that contains the DNA of the predators to Ben's Aliens.

Proctor Servantis (Ben 10: Omniverse) is a Cerebrocrustacean Hybrid who created the Amalgam Kids, A group of kids who are half-alien hybrids.

Maurice (Ben 10: Reboot) is a mad scientist who switched his body with a Cockroach.

Di Amara (Big Hero 6: The Series) is a mad scientist who is the clone of Liv Amara.

Obake/Bob Aken (Big Hero 6: The Series) is a mad scientist who's a genius with machines.

Chameleon (Birdman and the Galaxy Trio), created a serum that allowed him to shapeshift into whatever he wanted.

Doctor Shado/The Brain Thief (Birdman and the Galaxy Trio), Mad Scientist who used a device of his to steal information from four scientists.

Doctor Shark (Birdman and the Galaxy Trio), Mad Scientist with the face of a Shark.

Dr. Freezoid (Birdman and the Galaxy Trio) has a device that can turn an entire city block into ice. His headquarters are in the North Pole.

Dr. Mentaur (Birdman and the Galaxy Trio) and his creation: Birdgirl.

Dr. Millennium (Birdman and the Galaxy Trio), Mad Scientist with Time-Travel Tech.

Metallo's (Birdman and the Galaxy Trio) creation, The Incredible Magnatroid.

Morto the Marauder (Birdman and the Galaxy Trio) who's skilled in mechanical Know-How to build robotic creations. Not necessarily mad but he's evil.

Nitron the Human Bomb (Birdman and the Galaxy Trio), Radioactive Mad Scientist who got his Radioactive powers from a chemical called NITRON.

Professor Klaw (Birdman and the Galaxy Trio) with his creation: Ant Ape.

Professor Nightshade (Birdman and the Galaxy Trio) who stole a solar box that can send people/cities into the Fourth Dimension.

Reducto (Birdman and the Galaxy Trio), Green-Skinned Mad Scientist who carries a Shrink Gun.

Vulturo (Birdman and the Galaxy Trio), Vulture Costumed Mad Scientist.

Dr. Blood (Bolts and Blip) is the Main Antagonist of the series and created a vampire robot that infected some of the robots on the moon.

Doctor Blight (Captain Planet and the Planeteers) represents the dangers of Uncontrolled Technology and Unethical Scientific Experimentation, Even other Mad Scientists hate her.

Professor Thurdigree Burns (Casper's Scare School), Wacky Science Teacher of Scare School who teaches the monsters there some interesting experiments. Also uses Potions for experiments.

Ulmar (Chaotic)

Professor Norton Nimnul (Chip 'N Dale Rescue Rangers)

Chester (Codename: Kids Next Door) is a Mad Scientist who’s inventions are to cause nothing but misery to children.

Professor Bob (Codename: Kids Next Door) is a mad scientist inventing a weather-controlling device that will eliminate all snow days from schools.

Professor XXXL (Codename: Kids Next Door) is a mad scientist who is determined to create the perfect snow cone.

Doctor Von Goosewing (Count Duckula) is a Mad Scientist obsessed with hunting down and killing Count Duckula, Unaware that Duckula is harmless and is a vegetarian.

Di Lung (Courage the Cowardly Dog) is a Chinese Mad Scientist who is a a genius in Robotics and Potion Making, creating things like...

...Mecha Courage, a robotic version of Courage that nearly defeated/killed him, as well as...

...a Potion that turned Courage into a Fly or...

...turn people into Buffalos.

Dr. Gerbil (Courage the Cowardly Dog), A Mad Scientist Gerbil who experiments on Humans.

Dr. Zalost (Courage the Cowardly Dog), Slavic Mad Scientist who uses cannonballs that make people unhappy.

The Cruel Vet (Courage the Cowardly Dog), A Mad Doctor who sent dogs into Outer Space in the hopes of making them into Super Dogs.

Vlad Plasmius (Danny Phantom)

Dexter (Dexter's Laboratory), A Kid Mad Scientist who's a genius.

Mandark (Dexter's Laboratory)

Victor Veloci (DinoSquad) is a 65 million-year-old Velociraptor disguised as a Human. He wants to use his mad science to turn Earth back to the age of the Dinosaurs.

Mechanicles (Disney's Aladdin)

Major Dr. Ghastly (Evil Con Carne)

Stewie Griffin (Family Guy), Mad Scientist Baby and Enfant Terrible.

The Professor/Professor Nutty Nut-Meg (Felix the Cat) is a Mad Scientist who is determined to steal Felix’s Magic Bag of Tricks for his own use.

Dr. Dirk Spamflex (Fleabag Monkeyface) is a Mad Scientist TV Show Host who creates things like a giant ear monster in order to get his TV Show back.

Professor Hubert J. Farnsworth (Futurama)

Van Kleiss (Generator Rex) is a mad scientist who wants Earth to be entirely populated by E.V.O.'s. He has the power to steal nanites from others causing them to be petrified.

Old Man McGucket (Gravity Falls) who created multiple robots, like the Gobblewonker, and tinkered with voice changing serums.

Dr. Claw (Inspector Gadget), Mad Scientist/Mastermind and Arch-Nemesis of Inspector Gadget.

Dr. Focus (Inspector Gadget)

Professor Membrane (Invader Zim), A Mad Scientist who is the only smart man in his world.

ZIM (Invader Zim), an alien Mad Scientist.

Dr. Ashida (Jonny Quest)

Dr. Chu Sing Ling (Jonny Quest)

Dr. Zin (Jonny Quest)

Olaf (Kaeloo), is an Emperor Penguin Mad Scientist.

Dr. Drakken (Kim Possible)

Like Dr. Drakken, Professor Dementor (Kim Possible) is also a Mad Scientist. However, unlike Drakken, he is more Competent.

Dr. Emilia (Kipo and the Age of Wonderbeasts)

Awful Alvin (Larryboy: The Cartoon Adventures) is a Mad Scientist Scallion who creates angry eyebrows that latch themselves to anyone who cannot let go of their anger.

Gretta Von Gruesome (Larryboy: The Cartoon Adventures) is a female parody of Dr. Doom. She is a Zucchuni that once kidnapped yodelors because she loved yodeling so much.

The Alchemist/Edward "Cubby" Wiggins (Larryboy: The Cartoon Adventures) is a Carrot Mad Scientist who is a master of Chemistry as well as creating...

...The Alter-Ego Machine, A Machine that would remove someone's ego cloud and turn that ego cloud into a monstrous clone of themselves.

Doktor Frogg (League of Super Evil)

Dr. Jekyll (Looney Tunes)

Mad Scientist (Looney Tunes/Hair Raising Hare)

Mad Scientist (Looney Tunes/Water, Water Every Hare)

Camille (Mao Mao: Heroes of Pure Heart)

The Alien Scientist (Max Steel), Who created the Main Antagonist, Makino, with one goal, to absorb and expand.

Professor Mortum (Max Steel), Scientist who went Unstable and obsessed with getting rid of his mortality, resulting in him becoming a robot zombie.

Terrorax/Dr. Prometheus Halifax (Max Steel), who stole the T.U.R.B.O. Energy from Max and used it on himself...

...which mutated him into a monster.

Toxzon/Tytus Octavius Xander (Max Steel), Mentally Unstable Mad Scientist who became a mutant with the ability to control poisons/toxins.

Ludwig Von Drake (Mickey & Friends)

Dr. Cutter (Monsters vs. Aliens TV series) is a mad scientist who wanted to dissect an alien's brain in order to learn the secret to telekinesis.

Dr. Locus (My Life as a Teenage Robot) is famous for his creation: A Robotic Daughter named Melody.

Lord Boxman (OK K.O.! Let's Be Heroes), the owner of Boxmore, is a mad scientist who specializes in inventing and robotic engineering.

Heinz Doofenshmirtz (Phineas and Ferb)

Brain (Pinky and the Brain) is an Anthropomorphic Lab Rat Mad Scientist. He's Smarter than Lab Rat Pinky.

Willem Viceroy III (Randy Cunningham: 9th Grade Ninja), Mad Scientist and Right Hand Man of Hannibal Mcfist.

Rick Sanchez (Rick & Morty)

Entrapta (She-Ra and the Princesses of Power), A Mad Scientist who's experiments are more tech-based.

Dr. Quintin Kalowski (Slugterra) Who wants to create Roboslugs to replace Slugs.

Dr. Thaddius Black (Slugterra) who uses the dark science of Ghouling to corrupt slugs and turn them evil.

The Game Master (Slugterra) who designs eccentric games, which trap slugslingers, to steal their slugs.

Gargamel (Smurfs) is a Mad Wizard responsible for the creation of Smurfette.

Dr. Alphonse Mephesto (South Park), Mad Scientist who likes giving animals multiple asses instead of one.

Sheldon J. Plankton (Spongebob Squarepants), Arch-Nemesis to Mr. Krabs and creator of K.A.R.E.N, his computer/robotic wife.

Nuvo Vindi (Star Wars: The Clone Wars), A Faust Mad Scientist who wants to release a more deadly version of the Blue Shadow Virus.

Dr. Elrod Purvis/Dr.Viper (SWAT Kats: The Radical Squadron)

The Rat King/Victor Falco (Teenage Mutant Ninja Turtles 2012 TV series)

Victor Frankenstein (Teenage Mutant Ninja Turtles 2012 TV series)

Professor Chang (Teen Titans), Criminal Mad Scientist, and enemy to the Teen Titans.

Jimmy Neutron (The Adventures of Jimmy Neutron, Boy Genius) has created many inventions including Goddard, His pet robotic dog.

Nathan (The Garfield Show), Child Neighbor of Jon Arbuckle, and Mad Scientist. Also Arch-Nemesis of Garfield.

Professor "Thaddeus" Bonkers (The Garfield Show), Wacky Mad Scientist who's Inventions always lead to disaster.

Dr. Fruitenstein (The High Fructose Adventures of Annoying Orange) is a mad scientist cantaloupe who once shrunk orange and his friends in order for them to remove a small laser cannon implanted, by the Broccoli Overlord, in Nerville's Brain.

Lisa Loud (The Loud House) is a 4-year-old scientist who does strange experiments including creating oreo shaped cookies infused with the DNA of a jellyfish that cause people to glow when eaten. She also likes to experiment with her siblings and family.

Mito (The New Adventures of Nanoboy), Mad Scientist of the Microcosmos.

Dr. Blowhole (The Penguins of Madagascar), Bottlenose Dolphin with a Laser eye, and Arch-Enemy to the Penguins.

Mojo Jojo (The Powerpuff Girls) is a Chimpanzee Mad Scientist and Arch-Enemy of the Powerpuff Girls.

Angus (The Secret Files of Spy Dogs)

Professor Frink (The Simpsons), Springfield's Mad Scientist.

Dr. Otto (The Tom and Jerry Show)

Jonas Venture Sr. (The Venture Bros.) is a Super Scientist, The Venture Bros. name for a Mad Scientist. He once put his frozen brain into a robot.

Glowface (The X's) is an Expy of Dr. Evil and is a Dimwitted Genius/Mad Scientist, just like him, due to coming up with idiotic schemes like building a ray gun to bring monuments to life so they can wrestle and so he can sell tickets.

Mad Scientist (Tom and Jerry), A One-Shot Character who switched the minds of a Cat and a Dog.

Candy Sweet (Totally Spies) is a crazy girl who's also a genius in robotics. She developed a group of androids to destroy cheerleading.

Though not a scientist, Captain Hayes (Totally Spies) is a crazy genius who suffers from Celebrity Worship Syndrome. He has created devices and vehicles all in order to capture celebrities so they can live with him forever.

Coffee Guy (Totally Spies) is a mad genius who wanted to make everyone in the world drink his coffee, he created a coffee that would make anyone who drank it, mind-controlled.

Cosmo Stratus (Totally Spies) was a crazy woman who developed a device that nullified earth's gravitational pull.

Diminutive Smalls (Totally Spies) wanted to shrink the world and its tourist spots with his shrinking ray.

Dr. Gelee (Totally Spies) was a mad scientist who wanted to freeze the whole planet.

Dr. Inga Bittersweet (Totally Spies) developed a brand of cookies that would make anyone who ate them, addicted to them.

The Inventor (Totally Spies) is an Archetypal Mad Scientist. He wanted to create Spy-assassins to assassinate spies all over the world and developed weapons to kill spies.

Max Exterminatus (Totally Spies) was a bug exterminator who later become a geneticist. He turned himself into a Half-Bug hybrid and wanted to kill every non-bug life on earth.

Bird Brain (T.U.F.F. Puppy), Blue-Footed Booby Mad Scientist who can't fly, He makes it up with the various gadgets he's made.

Dean Cuizeen (Turbo Fast) created a evil version of the F.A.S.T. crew and later experimented on animals to turn them into Half-Chicken Hybrids.

Dr. Fox (Unikitty!)

Dr. Flug Slys (Villainous)

Nox/Noximilien Coxen (Wakfu) was a Mad Scientist who was obsessed with the Eliacube, a cube which could allow him to travel back in time to save his family from death, and his obsession eventually caused him to want to drain Wakfu of any and all sources in order to power the Eliacube.

Qilby (Wakfu)

While more of an Inventor than a Scientist Zachary "Zach" Varmitech (Wild Kratts) likes to perform experiments on wild animals he captures which includes mind control. His goal is to steal the Wild Kratt's technology and use the creature powers for himself. Also, his most famous creations are his Zachbots.

Dr. Two-Brains (Wordgirl), Mad Scientist who loves cheese and has an extra brain on his head.

Dr. Stankfoot/Stanley K. Foot (Zevo-3)

Comics/Webcomics

Stan Mayakovsky (Aliens: Harvest)

Paul Church (Aliens: Labyrinth)

While not a Scientist, Thomas Spears (Aliens: Nightmare Asylum) experimented on xenomorphs in order to turn them into controllable soldiers.

Waidslaw Orona (Aliens: Outbreak)

Ernst Kleist (Aliens: Rogue)

Caspar Nordling (Aliens: Stronghold)

Dr. Dinosaur (Atomic Robo)

Doktor Sleepless/John Reinhardt (Avatar Press)

Dr. Circula Tori (Awful Hospital: Seriously the Worst Ever), Mad doctor who's literally a living circulatory system with a peanut for a brain. Despite having no understanding of Human Anatomy, she can bring Humans back to life.

Doctor Dementist (Awful Hospital: Seriously the Worst Ever), A Mad Dentist who's a set of dentures inside of a Crab-like body that likes to drill holes and fill them in. He carries painful Tools and X-Rays that aren't even related to dentistry.

Dr. Dinea (Awful Hospital: Seriously the Worst Ever), who is a living leech jar that does leech therapy on people.

Dr. Gynnie Specula (Awful Hospital: Seriously the Worst Ever), Nice but does do crazy things sometimes. She takes on the form of a pink glove holding a speculum.

Dr. H. M. Phage, T. E. (Awful Hospital: Seriously the Worst Ever), Crazy Mad Doctor who is a Bacteriophage Virus.

Dr. Ichabod Malachi Man (Awful Hospital: Seriously the Worst Ever), Mad Doctor who's the only human doctor for the hospital staff.

Dr. Magdolene (Awful Hospital: Seriously the Worst Ever), Mad but Good/Nice Doctor that is a living skull who can telepathically control Maggots and Flies to form a Humanoid Body.

Dr. Phineas Fleagood (Awful Hospital: Seriously the Worst Ever), Mad Veterinarian that likes to use a syringe to extract large amounts of blood from animals and inject it into his mouth.

Dr. Phleboto Mizer (Awful Hospital: Seriously the Worst Ever), Assistant to Dr. H. M. Phage, T. E. and more rational than him.

Dr. Rory Shock (Awful Hospital: Seriously the Worst Ever), Mad Psychiatrist, and flying inkling blot.

Dr. Ucy (Awful Hospital: Seriously the Worst Ever), Mysterious Mad Doctor who theoretically works at the optometry ward.

Molly Curdle (Awful Hospital: Seriously the Worst Ever), Sentient Medical Waste Bag Who's a nurse that sucks at treating someone's Malaria. Also enjoys killing patients.

Dr. Everton Morteus Balmer (Awful Hospital: Seriously the Worst Ever), A sentient Embalming Device who really likes Sterilizing, Preserving, and Archiving Dead Bodies.

Ghastly Physician Worm (Awful Hospital: Seriously the Worst Ever), Mad Doctor Worm that likes to grab opponents with his tongue and drain them of their health.

Unnecessary Surgery Worm (Awful Hospital: Seriously the Worst Ever), Mad Doctor Worm that, as its name implies, likes to perform unnecessary surgeries on people. The worm is also hostile to others.

Catherine Fortune (Batman/Aliens II) is a mad scientist who created xenomorph hybrids from the DNA of Batman Villains.

Casey and Andy (Casey and Andy)

Dr. Leonard Price (Chaos! Comics)

Jyrras Gianna (Dan and Mab's Furry Adventures) is a Half Kangaroo/Kangaroo Rat Mad Scientist who likes to mix Magic/Sorcery with Science.

Blockbuster/Mark Desmond (DC Comics), Mad Chemist who experimented on himself to increase his strength.

Despite being nothing more than a brain in a jar, The Brain (DC Comics) is one of the most dangerous foes due to his immense knowledge of combating opponents. Before becoming nothing more than just a brain, He experimented on animals to raise their intelligence.

Brainiac I/Vril Dox (DC Comics), an Alien Cyborg who collects worlds to study and experiments on their populations. After collecting the world, he destroys the remnants.

Bug Baron (DC Comics)

Doctor Cyclops (DC Comics)

Doctor Death (DC Comics)

Doctor Thaddeus Bodog Sivana (DC Comics), a mad scientist who is apparently able to walk through walls by using mathematical equations.

Doctor Tyme/Percival Sutter (DC Comics)

Doctor William Magnus (DC Comics)

Dr. Hugo Strange (DC Comics) is a Mad Doctor/Scientist who is one of the few characters in the DC universe to know Batman's Secret Identity.

Egg Fu/Chang Tzu (DC Comics)

Floronic Man (DC Comics)

A former small-time crook, IQ/Ira Quimby (DC Comics) became super-intelligent after being exposed to Zeta Beam radiation.

Jax-Ur (DC Comics), Kryptonian Mad Scientist.

Komrade Krabb (DC Comics)

Krona (DC Comics), Maltusian Mad Scientist with a thirst for knowledge and has the power to create/destroy universes.

Lex Luthor (DC Comics)

The Mad Hatter (DC Comics), who uses his mad science to make technology that hypnotizes people. He's also a skilled neurotechnician.

Man-Bat/Kirk Langstrom (DC Comics) used a serum that would cure his deafness but became a monstrous Human-Bat hybrid.

Mr. Freeze/Victor Fries (DC Comics), a Mad Scientist skilled in Cryogenics and is determined to save his wife Nora.

Poison Ivy/Pamela Isley (DC Comics), Mad Botanist who gained the ability to control plant life.

Professor Achilles Milo (DC Comics)

Professor Anthony Ivo (DC Comics)

Professor Pyg (DC Comics)

The Riddler (DC Comics), Mad Genius who likes using riddles and puzzles in his plans/schemes.

A mad scientist, Rigoro Mortis (DC Comics) is the inventor of Super-Hood.

A brilliant scientist, Riot/Frederick von Frankenstein (DC Comics) while working with a phase shifter he unlocked his metahuman ability to create duplicates of himself but went insane due to his inability to sleep due to his multiple bodies.

Robert Quinlan (DC Comics) is a Mad Scientist who captured a group of Homeless/Run away children to experiment on. He also sends them to clean up/investigate his other dangerous experiments.

Scarecrow/Jonathan Crane (DC Comics) is a Mad Psychologist determined to find out what other people's fears are.

T.O. Morrow (DC Comics)

A genius super-villain and an enemy to the Justice Society and Superman, The Ultra-Humanite (DC Comics) have invented a vast array of advanced weapons, vehicles, and other arcane technology.

A brilliant scientist and an enemy to Wonder Woman, Veronica Cale (DC Comics) is a genius pharmaceutical tycoon, master manipulator, and bio-engineer with a triple Ph.D. from Harvard.

An enemy of the Teen Titans, The Zookeeper/Sam Register (DC Comics) is a skilled geneticist who became obsessed with Beast Boy's parents' research after they saved their son from the Sakutia virus as he became convinced that they had inadvertently discovered the biogenetic missing link between animal and human...

...after inadvertently infecting himself with Sakutia, he discovered that the virus had become airborne and mutated as it infected children within the San Francisco area found themselves suddenly shapeshifting into green-colored animals...

...he begin experimenting on them while searching for a cure.

Dr. Germahn (El Goonish Shive)

Lord Tedd (El Goonish Shive), a black-eyed alternate universe version of Mad Scientist Tedd Verres.

Tedd Verres (El Goonish Shive)

Dr. Mindbender (G.I. Joe)

Dr. Venom (G.I. Joe)

Agatha Clay/Heterodyne (Girl Genius), The Heroic Mad Scientist Protagonist of Girl Genius.

Gilgamesh Wulfenbach (Girl Genius)

Zio Boris (Horror) is a mad scientist who has a Werewolf, a Flying Skull, and a Vampire assist him in his experiments.

Abraham Cornelius (Marvel Comics)

Members of A.I.M., Advanced Idea Mechanics, (Marvel Comics)

Aliana Alba (Marvel Comics)

Alistair Alphonso Smythe (Marvel Comics) developed a Bio-organic Carapace and a new generation of Spider-Slayers in order to kill Spider-Man and avenge his father's death.

A swiss turned nazi, Arnim Zola (Marvel Comics) is a mad scientist who transferred his mind into a robotic body and is an enemy of Captain America.

Baron Heinrich Zemo (Marvel Comics) was a German Mad Scientist who developed Adhesive X, an adhesive that was so sticky that there was no way to remove it. He also developed weapons that would have let the Nazis win WWII.

Bolivar Trask (Marvel Comics), an Anthropologist and the original creator of the Mutant Killing Robots, The Sentinels.

Dale Rice (Marvel Comics) is the father of Zander Rice and worked for the Weapon X project.

David Moreau (Marvel Comics)

Doctor Faustus/Johann Fennhoff (Marvel Comics), Mad Psychiatrist, and Adversary to Captain America.

Doctor Octopus (Marvel Comics), a deadly Arch-Enemy of Spider-Man.

Dr. Steven Lang (Marvel Comics), Anti-Mutant Bigot and creator of the Mark III Sentinels: Giant Robots designed to combat, capture, and kill Mutants.

Egghead/Elihas Starr (Marvel Comics)

A brilliant man, Hank Pym (Marvel Comics) can be considered a mad scientist due to inventing and creating a multitude of devices, A.I.s, and discovering the famous Pym Particles.

The High Evolutionary (Marvel Comics)

Horst Gorscht (Marvel Comics) was a Nazi Mad Scientist who created a flawed version of the super soldier serum that turned villains like Master Man and Warrior Woman into super humans. He planned on cloning Hitler’s brain and removing the memories of it so he could implant those memories into every child born into his planned fourth reich. He was killed before he could do so.

Lady Octopus (Marvel Comics), protégée of Doctor Octopus.

Lyle Dekker (Marvel Comics) was a Nazi Scientist who transferred his mind into a 12 ft tall android version of Cap called the Ameridroid.

Machinesmith (Marvel Comics) is a mad scientist who specializes in robotics.

Martin Sutter (Marvel Comics)

Mister Hyde (Marvel Comics)

Mister Sinister/Nathaniel Essex (Marvel Comics) is a Mad Scientist/Geneticist responsible for the creation of the Time-Traveling Mutant soldier, Cable.

M.O.D.O.K./Mental Organism Designed Only For Killing (Marvel Comics)

The Mole Man (Marvel Comics), Who wants revenge against the world due to people making fun of his appearance. Also leads the Moloids.

Norman Osborn (Marvel Comics), Mad Scientist and Arch-Enemy of Spiderman.

The Red Skull/Johann Schmidt (Marvel Comics) who supported Arnim Zola and conducted many experiments with the Cosmic Cube.

Robert Chandler (Marvel Comics)

Spencer Smythe (Marvel Comics) developed the Spider-Slayers to kill Spider-Man. His obsession with the web-crawler later caused his death, which was due to radiation. He is the father of Alistair Alphonso Smythe.

Stegron (Marvel Comics) was a scientist who injected himself with Dinosaur DNA and gained the ability to command real dinosaurs. He planned to conquer the world and turn everyone into dinosaurs.

Superia/Deidre Wentworth (Marvel Comics) is a female mad scientist who wants to eliminate/enslave all men.

The Intelligencia (Marvel Comics) is a villainous organization composed of some of the greatest Mad Scientists of the Marvel Universe.

The Leader (Marvel Comics)

The Lizard/Curt Connors (Marvel Comics), Scientist who used Lizard DNA to regrow his lost left arm...

...but, unfortunately, turned himself into the Lizard, a vicious creature and deadly enemy of Spider-Man.

The Mad Thinker (Marvel Comics)

Truett Hudson (Marvel Comics)

Unlike his creator/father Hank Pym, Ultron (Marvel Comics) is a Mad Scientist A.I. whose were brain patterns are were modeled on his creator but with lack any morals as he desired the eradication of all humanity and organic life. He is also responsible for the creation of some of the greatest and deadliest forms of artificial lifeforms...

...a "synthezoid," an advanced android, who was built to replicate the human form using Horton Cells, the Vision was originally created to destroy his creator's enemies, the Avengers, but rebelled against him as he would later join them while becoming one of its leading members...

...built as his chosen mate, Jocasta rebelled against her intended husband she wanted to destroy her evil creator...

...like Jocasta, Alkhema was the second of two "female" robots created by the Ultron to serve as his bride but was more ruthless than Ultron's first bride as she found an outlet in violence and sadism while taking human life with child-like glee...

...the youngest among Ultron's children, Victor Mancha was created from his father's cybernetics and his mother's human DNA in an attempt to create the perfected cyborg/unsuspecting sleeper agent.

Victor Von Doom (Marvel Comics) is a mad scientist who is also one of the greatest users of prep time.

William Taurey (Marvel Comics) is a British Mad Scientist who created the Madbomb, A device emitted sonic waves that would drive American Citizens into mindless beasts.

Zander Rice (Marvel Comics)

Doctor Niels Reinstöt (Predator vs. Judge Dredd vs. Aliens: Splice and Dice)

Doc Krok (Sardine in Outer Space) and his employer, Supermuscleman.

Dr. Catherine Crabtree (Sluggy Freelance)

Dr. Irving Schlock (Sluggy Freelance)

Dr. Scabmoreaueau (Sluggy Freelance), A Mad Scientist Elf who wears a Head Mirror.

Dr. Steve Hereti (Sluggy Freelance)

Riff (Sluggy Freelance)

Baxter Stockman (Teenage Mutant Ninja Turtles)

Dr. Lewis W. Breign (The Snail Factory), Sentient Mad Brain who is the CEO of Snail Factory. He also makes a lot of poor decisions.

Doctor Terminal (The Umbrella Academy)

Live Television/Movies

Dr. Wolfowitz (3 Pigs and a Baby) is a wolf mad scientist who proposed an idea to the wolves of having the pigs raise a baby wolf.

Ash (Alien)

Jonathan Gediman (Alien Resurrection) is a Mad Scientist who's even madder than Mason.

Mason Wren (Alien Resurrection) was one of the many scientists who created a clone of Ellen Ripley.

Gaetan "Mole" Moliére (Atlantis: The Lost Empire) is a Crazy/Mad Geologist who is a genius at inventing things related to Excavation. So far he has invented 62 of them and holds patents for 59 of them.

Dr. Evil (Austin Powers), silly Mad Scientist whose evil plans are often not as evil as you'd think they'd be. Also a parody of Ernst Stavro Blofeld.

Emmett L. Brown (Back to the Future) is a crazy, not evil, a mad scientist who created the DeLorean Time Machine.

Honey Lemon (Big Hero 6)

Doctor Septimus Pretorius (Bride of Frankenstein), Amoral Egomaniac who wants Frankenstein to continue his experiments with dead flesh.

Professor Zündapp (Cars 2) is an anthropomorphic 1957 Zündapp Janus who invented an EMP designed to cause Gasoline to ignite inside Cars when hit by it.

Flint Lockwood (Cloudy with a Chance of Meatballs) created the Flint Lockwood Diatonic Super Mutating Dynamic Food Replicator or FLDSMDFR for short, It's a device that turns water into any kind of food.

As a Mad Scientist, Dr. Joseph Albert Nefario (Despicable Me) works for Gru and the Minions. He creates many inventions like the Fart Gun and Cookie Bots.

Davros (Doctor Who) once tried to destroy all of reality itself due to his evil mad scientist ways.

Omega (Doctor Who) was a Time Lord Scientist who ended up isolated in an Anti-Matter Universe which made him insane. He planned to flood the main universe with Anti-Matter.

Rani (Doctor Who)

Rassilon (Doctor Who), Leader of the Time Lords and likes to mess with the universe.

Richard Lazarus (Doctor Who) created a machine that made him young again...

but turned him into a horrific monster that stole the life energy of others in order to survive.

The Doctor (Doctor Who) can be considered a Mad Scientist due to her/his eccentricity when it comes to making gadgets and inventions.

The Master (Doctor Who), Mad Time Lord who is very good with science and other fields. Also a FOIL to The Doctor.

Dr. Horrible (Dr. Horrible's Sing-Along Blog)

Dr. Strangelove/Merkwürdigliebe (Dr. Strangelove), Former Nazi who specializes in making Doomsday Weapons and Nuclear Warfare.

Dr. Preturius (Felidae)

Dr. Hans Zarkov (Flash Gordon), who builds a rocket ship and forces flash and his friends to help him fight Ming the Merciless.

Victor Frankenstein (Frankenweenie) used his mad science to bring his dead dog Sparky back to life.

Dr. William Bell (Fringe)

Walter Bishop (Fringe)

Dr. Edward Pretorius (From Beyond), Mad Scientist who developed a device called the Resonator, A device that stimulates the Pineal Gland and lets anyone within range to see beyond normal perceptible reality.

Dr. Daisuke Serizawa (Godzilla Series), Reluctant Mad Scientist who created the oxygen destroyer and sacrificed himself to kill Godzilla.

Shunned by Society, Dr. Shinzo Mafune (Godzilla Series) thirsts for revenge. He also claims he has a means of controlling sea life.

Driven by grief because of the death of his daughter, Genshiro Shiragami (Godzilla Series) created Biollante, A monster made from the DNA of Godzilla, a Rose, and his Daughter.

Dr. Phillip Channard (Hellbound: Hellraiser II)

Mohinder Suresh (Heroes)

Dr. Glickenstein (Igor)

Unlike other Mad Scientists, Dr. Schadenfreude (Igor) prefers to cheat in order to win the yearly evil science fairs.

Ernst Stavo Blofeld (James Bond), Mad Scientist and Leader of the terrorist organization SPECTRE. Also the Arch-Enemy of Bond.

Hugo Drax (James Bond) planned to use his mad science to poison everyone on earth and then repopulate it with a population from his space station.

Julius No (James Bond), Mad Scientist, and one of the most famous villains in the James Bond series.

Thanks to his Mad Science, Dr. Henry Wu (Jurassic Park) is responsible for the revival of many extinct animals like the T-Rex and Velociraptor.

Shocker (Kamen Rider), A terrorist organization full of mad scientists.

Doctor Gao (Lab Rats) who creates missiles to wipe out humanity and injects serums into innocent people to turn them into bionic slaves.

Unlike other Mad Scientists, Donald Davenport (Lab Rats) is one under the Rule of Funny.

Douglas Davenport (Lab Rats)

Jumba Jookiba (Lilo & Stitch)

Dr. Isaac Taft (Lost Girl)

Darren Cross (Marvel Cinematic Universe), Protege of Hank Pym that tried to recreate Hank's Pym Particle Technology...

...which caused his mind to become insane and made him create a weapon suit called the Yellow Jacket.

Leopold James Fitz (Marvel Cinematic Universe)

Megamind (Megamind) created many inventions with his Mad Science including The Spider Bot, The Brain Bots, and The De-Gun.

Doctor Frankenollie (Mickey Mouse: Runaway Brain)

Dr. Cockroach (Monsters Vs. Aliens), Mad Scientist who became a Cockroach.

Dr. Clayton Deborah Susan Forrester (Mystery Science Theater 3000)

Pearl Forrester (Mystery Science Theater 3000)

While not Evil, Agent Oscar’s (Odd Squad) inventions can cause a lot of problems when they go wrong.

Agent Oona (Odd Squad) is a mad scientist who can be a bit nuts sometimes.

Dave (Penguins of Madagascar: The Movie) is a Octopus Mad Scientist who is jealous of the penguins. He later turned them into monstrous freaks in order for humans to hate them.

Professor Kipple (Planet 51) wanted to remove Chuck Baker's Brain so he could study it.

David (Prometheus)

Shiro Ito/Dragon King (Stargirl)

Dr. Cornelius Evazan (Star Wars), a Mad Doctor/Scientist whose scientific crimes earned him twelve death sentences.

Dr. DeMarco (The Astro-Zombies)

Skektek the Scientist (The Dark Crystal Series)

Yzma (The Emperor's New Groove)

Andre Delambre (The Fly (1958) ), Who becomes a Half-Fly/Half-Human Hybrid.

Because of his Mad Science Experiments, Seth Brundle (The Fly (1986) ) became a Half-Fly Hybrid.

Anton Bartok (The Fly II)

Syndrome (The Incredibles) created the Omnidroids, using his mad science, to kill lots of heroes.

Dr. Janos Rukh (The Invisible Ray) and his Raygun-like Invention.

Dr. Shrinker (The Krofft Supershow) develops a shrink ray that can shrink anything.

Dr. Faust (The Last Faust)

Dr. Bunsen Honeydew (The Muppet Show), A idiotic Mad Scientist whose experiments often hurt his lab assistant Beaker.

Dr. Finkelstein (The Nightmare Before Christmas)

The Nutty Professor (The Nutty Professor)

Dan Cain (The Re-Animator)

Dr. Carl Hill (The Re-Animator)

Dr. Hans Gruber (The Re-Animator)

Herbert West (The Re-Animator)

Professor Waldo Cunningham (The Return of Captain Nemo)

Frank-N-Furter (The Rocky Horror Picture Show) is determined to create the perfect life form which will become his sexual plaything.

Dr. Miguelito Quixote Loveless (The Wild Wild West), Dwarfish Mad Scientist who is able to produce inventions far ahead of his time.

Dr. Federick Frankenstein (The Young Frankenstein)

Dr. Professor (Tom and Jerry: The Fast and the Furry) was a scientist who created a Anti-Matter powered Vehicle. He was later killed by his own Invention.

Robert Ford (Westworld)

Colonel William "Bill" Stryker Jr. (X2: X-Men United) experimented on mutants, including Wolverine, and uses a serum to control them.

Literature/Magazines

Captain Nemo (20,000 Leagues Under the Sea), created a submarine powered by a nuclear reactor, long before Nuclear Energy was even discovered. He has vengeful hate towards the nation who tortured him in order to extract scientific knowledge from him, which is why he attacks any ship from that nation.

Abdul-Aziz al-Rahim (Alex Rider), Member of Saddam Hussein's Secret Police, The Mukharabat, and Ex-Al-Qaeda Terrorist who tortures and experiments on people in order to create a unit of measurement for pain.

Dr. Hugo Grief (Alex Rider), South African scientist who cloned himself 16 times. He planned to reinstate Apartheid globally but was later killed by Alex when his helicopter got hit by a snowmobile. Before his death, he planned to vivisect Alex alive in front of his clones.

Opal Koboi (Artemis Fowl Series)

Qyburn (A Song of Ice and Fire) studied Necromancy and vivisected live bodies in order to discover the secrets of Death.

Dr. Phillip K. Decker (Cabal)

Tippy Tinkletrousers/Professor Pippy P. Poopypants (Captain Underpants), Professor who went mad after people continually laughed at his name. He's also the Arch-Enemy to our Caped Baldie.

A Mad Scientist (City of Devils), one of many in the City of Devils.

The Alchemists' Guild (Discworld)

Doctor Death (Doctor Death), Mad Scientist who also uses Magic, Hypnotism, and Zombies.

Morlock (Doctor Who Prose)

The Other (Doctor Who Prose), one of the original founders of Time Lord Society along with Omega and Rassilon.

Dr. Mabuse (Dr. Mabuse, the Gambler)

Dr. Frankenstein (Frankenstein's Monster)

Franny K. Stein (Franny K. Stein) is a Little Girl who's mad science creates things like a two-headed robot and a pumpkin monster that chews gum. Her Igor is a dog.

Dr. Crawford Tillinghast (From Beyond (Book Version) )

Faust (German Folklore) was a scientist who made a deal with the Devil, Mephistopheles and traded his soul for unlimited knowledge. However, he later becomes corrupted and sent to hell by the Devil.

C. A. Rotwang (Metropolis), Mad Scientist skilled in Chemistry and Robotics.

Dr. Jigsaw (N.E.R.D.S.: National Espionage, Rescue, and Defense Society) was a Mad Scientist who wanted to turn earth back into Pangaea.

Dr. Stinky McNasty (Ricky Ricotta's Mighty Robot) created the Robot that would be Ricky Ricotta's best friend.

Mr. Mosquito (Ricky Ricotta's Mighty Robot)

Victor Von Vulture (Ricky Ricotta's Mighty Robot)

Major Monkey (Ricky Ricotta's Mighty Robot)

General Jackrabbit (Ricky Ricotta's Mighty Robot)

Sergeant Stinkbug (Ricky Ricotta's Mighty Robot)

Uncle Unicorn (Ricky Ricotta's Mighty Robot)

Nimrod Nightcrawler (Ricky Ricotta's Mighty Robot)

President Penguin (Ricky Ricotta's Mighty Robot)

Dr. Impossible (Soon I Will be Invincible)

Belia Darzu (Star Wars Legends), Who used Sith Alchemy to create a Technovirus that turned people into Technobeasts.

An engineer and architect, Bevel Lemelisk (Star Wars Legends) designed and helped build six superweapons with the power to destroy a planet.

Naga Sadow (Star Wars Legends), who could use Sith Alchemy to turn people into Monstrous beasts for him to control as well as cause supernovas.

Josef Mengele (The Boys From Brazil), who creates multiple clones of Hitler.

Griffin (The Invisible Man), Mad Scientist who found a way to turn himself invisible and became insane.

Dr. Moreau (The Island of Dr. Moreau)

Ras Thavas (The Master Mind of Mars), A Martian Mad Scientist with no regard for the social consequences of his discoveries or inventions.

Dr. Jekyll (The Strange Case of Dr. Jekyll and Mr. Hyde) created his famous split personality thanks to his mad science.

De Selby (The Third Policeman)

Belphegor (Whateley Academy) is a Mad Scientist who's also Arrogant, Cowardly, and a Kleptomaniac.

While not necessarily mad, John Ann Wilkins's (Whateley Academy) Blue-And-Orange Morality means there's a lot of unethical things he will do without any care for the consequences.

String Theory (Worm) is a mad scientist who is the poster child of a World Threatening version of one. It's stated she is capable of blowing the Moon in half.

Music Videos

The Mad Scientist (They Might Be Giants - I Am Invisible) riding on a shopping cart.

RPGs/Trading Card Games

Doctor Loctus Khan Schwarzwald (Anima: Beyond Fantasy)

Nadul DaRoni (Forgotten Realms/Dungeons and Dragons), Gnomish Inventor and Madman.

Dr. Arkadius (Hordes) specializes in Animal Cyberization with his Mad Science. He once created an army of Cyborg Pigs for Genghis Pig-Khan.

Izzet League (Magic: The Gathering) is an entire guild of Mad Scientists.

Jin Gitaxias (Magic: The Gathering)

Laboratory Maniac (Magic: The Gathering)

Niv-Mizzet (Magic: The Gathering), Leader of the Izzet League.

Simic Combine (Magic: The Gathering) is another Mad Scientist Guild in the Magic: The Gathering universe.

Vannifar (Magic: The Gathering) is the leader of the Simic Combine and is an Elf/Ooze Hybrid.

Using his Mad Science, Yawgmoth (Magic: The Gathering) created Plagues, Subversive Nanotech Oil, and the Bio-Mechanical Race known as the Phyrexians.

Dr. McMourning (Malifaux) likes making Mortem Chimerism for his Mad Science, an example would be building Centaurs out of Human and Horse Corpses.

Doctor DeathBreath (Super Munchkin/Munchkin Series)

Belisarius Cawl (Warhammer 40,000) works for the Imperium of Man and is responsible for the creation of the Primaris Space Marines.

Fabius Bile (Warhammer 40,000), Mad Scientist who's aligned with Chaos.

Stormsmith Storm Towers (Warmachine) are Mad Scientists who specialize with Lightning.

Video Games

Professor Brains (Age of Zombies)

Arnaud Eisenberg (Aliens versus Predator 2)

Samuel Kadinsky (Aliens versus Predator: Extinction) observing his creations.

H. G. Groves (Aliens vs. Predator)

Karl Bishop Weyland (Aliens vs. Predator)

Dr. Coyle (ARMS)

Klungo (Banjo-Kazooie), Orge-Like Mad Scientist, and Igor/Minion to Gruntilda.

Alice Angel (Bendy and the Ink Machine)

Mad Scientist Yi Suchong (BioShock), The man behind the creation of the Little Sisters and the Big Daddies.

Kokonoe Mercury (Blazblue), A Heroic Mad Scientist counterpart to Relius Clover.

Relius Clover (Blazblue), The Villainous Mad Scientist Counterpart to Kokonoe Mercury.

Dr. Ned (Borderlands), Dr. Zed's Identical Twin Brother who creates Wereskags and Zombies.

Dr. Zed (Borderlands), Back-Alley Mad Doctor.

Gaige (Borderlands 2), Gadgeteer Genius who acts/becomes mad when gaining stacks of Anarchy. She also built a Robot for a Science Fair.

Handsome Jack (Borderlands 2), Mad Engineer who's skilled in computer programming and built the Fragtrap.

Professor Nakayama (Borderlands 2), Idiotic Mad Scientist, and one of Handsome Jack's most loyal followers. He's at least skilled in creating genetic abominations but is often treated as a joke.

Oletta (Borderlands 3), Mad Scientist who fits more of the Scientist part than the Demeanor part.

Doctor Spara (Borderlands: The Pre-Sequel), She uses Tork and Human Brains as a Rocket Guidance System.

A Clown Surgeon (CarnEvil), Mad Doctor Mooks sent by Ludwig Von Tökkentäkker to extract the Protagonist's Brain.

Ludwig von Tökkentäkker (CarnEvil) wants to send a army of Crazy Clown Doctors to extract the Protagonist's Brain and put it into a Gorilla.

Dr. Thrax (Command and Conquer: Generals) created a lot of Biological and Chemical weapons, using his mad science, including Anthrax that can melt vehicles.

Professor von Kriplespac (Conker's Bad Fur Day/Conker: Live & Reloaded)

Dr. Nefarious Tropy (Crash Bandicoot Series)

Dr. Neo Cortex (Crash Bandicoot Series)

Dr. N. Gin (Crash Bandicoot Series)

Dr. Nitrus Brio (Crash Bandicoot Series)

The Scientists (Critter Escape) capture critters and experiment on them, resulting in the above.

Dr. Kahl (Cuphead) and his robotic creation.

The Scientist (Dark Escape 4D) who put our nameless protagonist and Courtney Wall against hundreds of his Dastardly creations.

Herman Carter (Dead by Daylight)

Talbot Grimes (Dead by Daylight)

Victor Donovan (Dead or Alive), Mad Geneticist who created multiple clones of Kasumi.

Albert Contiello (Dead Rising 3), Mad Surgeon who does horrific/sadistic surgery on people and sells their organs on the black market.

Doctor Mayhem (Defenders of Dynatron City)

Orthropox (Destroy All Humans) is a Furon Mad Scientist who provides Crypto all the upgrades/weapons he uses.

Bob Page (Deus Ex), Though not very skilled with science himself, Respects it and uses it to create conglomerates that will help him rule the world.

Dr. Andonuts (Earthbound)

Mad Doctor (Epic Mickey Series)

The Master (Fallout)

Dr. Stanislaus Braun (Fallout 3)

Professor Calvert (Fallout 3) is a mad scientist that has become nothing but a brain in a jar.

The Think Tanks (Fallout: New Vegas) are a group of Mad Scientists who are brains inside a robot body, Allowing them to live past their biological life spans.

Doctor Lugae (Final Fantasy IV)

Kefka Palazzo (Final Fantasy VI)

Professor Hojo (Final Fantasy VII), Creator of Sephiroth, and Mastermind of SOLDIER and the Jenova Project.

William Afton (Five Nights at Freddy's Series) created Animatronics that would kidnap and kill children. The souls of the children would then be trapped in the Animatronics.

Dr. Rachel Claudius (God Eater 2), Vice Chief Supervisor of the Fenrir Friar Branch Aragami Technology Department.

Dr. Labrat (Grand Theft Auto 2)

Faust/Dr. Baldhead (Guilty Gear Series) is a Mad Doctor who is trying to atone for his past sins. However he will occasionaly relapse into his psychotic persona.

Members of Aperture Science (Half-Life/Portal) are mad scientists that created many inventions such as the Portal Gun.

Kevin Clamely/Patriarch (Killing Floor)

Hans Volter (Killing Floor 2)

Vexen (Kingdom Hearts) created a replica of Riku using his Mad Science in order to conduct experiments on Riku and Sora.

Xehanort (Kingdom Hearts) is responsible for many of the events that threaten the Kingdom Hearts world.

Professor Cecil B. Heimerdinger (League of Legends), an innovative and brilliant yet eccentric yordle scientist.

Professor Von Yipp (Legends of Runeterra) is a Cat Mad scientist who's Human Assistant is his translator. Unlike other Mad Scientists, He doesn't perform experiments himself. He scams humans to do them for him.

Skeleton Mad Scientist (Lego Universe)

Professor E. Gadd (Luigi's Mansion) is a mad but heroic scientist who creates weapons designed to deal with bad ghosts.

Fawful (Mario & Luigi Series)

Henry Lawson (Mass Effect)

Doctor Albert W. Wily (Mega Man), Mad scientist and Arch-Nemesis to Mega Man.

Dr. Weil (Mega Man Zero) is a Mad Scientist whose evilness makes Wily look like a Saint.

The Amadeus Syndicate (Metal Slug 4/Attack) is a Syndicate composed of Mad Scientists and Hackers.

The Doctor (Metal Slug 4) is the Mad Scientist Leader of the Amadeus Syndicate.

Scientists (Metal Slug 4) are Mad Scientists who work for the Amadeus Syndicate. They carry guns that can turn the player into a monkey.

Alma (Metal Slug Attack) is a Mad Scientist working for the Amadeus Syndicate. She created a virus that enables her to turn into an animal.

Franke (Metal Slug Attack) is a Half-Alien Hybrid Scientist who wants to turn other humans into Half-Aliens.

Percier (Metal Slug Attack) is the Professor's Assistant and likes to create poisons.

The Professor (Metal Slug Attack) was a Mad Scientist who once worked for the Rebel Army and later the Martians. He is able to create clones of people, mutate others, and create various different robots.

Navy (Metal Slug Attack) once worked with the Professor. She is responsible for turning Vita into a cyborg.

Quan Chi (Mortal Kombat), Mad Sorcerer who's most famous Creations/Experiments are the Revenants he makes out of dead people.

While he is a more of a sorcerer than a scientist, Shang Tsung (Mortal Kombat) has conducted many experiments as well including the creation of Mileena.

Dr. Manhole (Mr. Driller Series)

Working as part of the cult itself, as well as within the fringes and within the facilities of Dusk, the Scientists (New Blood Interactive's DUSK) are dangerously psychotic individuals that can go out of their way to attack whoever interferes with the Cult's plan of both destroying and ruling the universe.

Moira O’Deorain (Overwatch) is responsible for Gabriel Reye's Transformation to Reaper.

Sigma (Overwatch) is a Dutch Mad Scientist with the ability to control Gravity.

Crazy Dave (Plants Vs. Zombies) is responsible for the creation of the plants. He once invented a device that made Ice Cream Unmeltable.

Dr. Edgar George Zomboss (Plants Vs. Zombies) is a Zombie Mad Scientist determined to rule the world and destroy those pesky plants once and for all.

Dr. Hare (Poptropica) is a Mad Scientist who's brain was altered and fused with a rabbit's. He has an obsession with carrots.

Alex Mercer (Prototype), Mad Scientist that created a virus that absorbed him and adopted his identity.

Dr. Anton Koenig (Prototype) was a Mad Scientist who became a minion of Mercer and performed experiments on Heller.

Raymond McMullen (Prototype) is a subtle mad scientist fascinated with the Blacklight Virus.

Dr. Loboto (Psychonauts) is a Mad Dentist who carries powder that makes people sneeze their brains out.

Dr. Nefarious (Ratchet & Clank)

The Umbrella Corporation (Resident Evil) is filled with Mad Scientist Staff.

Albert Wesker (Resident Evil), Mad Scientist with a huge belief in Social Darwinism.

Alexia Ashford (Resident Evil)

James Marcus (Resident Evil)

Oswell Spencer (Resident Evil)

William Birkin (Resident Evil)

Doctor Merlot (RWBY: Grimm Eclipse) is a scientist who specializes in grimm-based experiminations.

Dr. Jekyll (Scribblenaut Series) can eat a potion which...

...turns him into Mister Hyde.

The Mad Scientist (Scribblenaut Series) can be male...

...or Female.

Elexis Sinclaire (SiN Series)

Brain Drain (Skullgirls), The Mad Scientist responsible for the creation of Painwheel.

Valentine (Skullgirls), Mad Doctor, and Assistant to Brain Drain. She's also very skilled at Fighting/Killing people as well.

Dr. Krankcase (Skylanders), The Mad Scientist of the Doom Raiders group.

Pop Fizz (Skylanders) Mad Alchemist who drinks potions that give him powers.

Dr. M (Sly Cooper)

Doctor Eggman (Sonic the Hedgehog)

Eggman Nega (Sonic the Hedgehog)

Professor Gerald Robotnik (Sonic the Hedgehog) went mad after his granddaughter's death, engineering doomsday weapons for revenge against all of humanity.

Egon Stetmann (Starcraft), A benign version of this trope.

Andross (Star Fox) is a Mad Ape Scientist and the Arch-Enemy of Fox McCloud.

Rintaro Okabe (Steins;Gate), Mad Scientist who specializes in Time Travel.

Dr. Fetus (Super Meat Boy) is a Mad Scientist who kidnaps Meat Boy's girlfriend and creates several bosses to try to stop him from rescuing her. He also wants to make sure Meat Boy dies.

Furst (Taimanin Asagi)

The Engineer's (Team Fortress 2) most famous creations are his sentry guns. This Mad Inventor also has 12 PhDs.

The Medic (Team Fortress 2) has made a lot of Unethical/Crazy Experiments including removing a patients skeleton without killing them, Reviving a guy that was dead 7 hours ago, Replacing the Heavy's heart with a Baboon one, and selling his soul along with the souls of the other mercs to the Devil.

Dr. Bosconovitch (Tekken), Reluctant Mad Scientist who is determined to revive his Daughter.

Neloth (The Elder Scrolls), eccentric Wizard-Lord who wants to have a Dragon as a test subject.

Dr. Roy Curien (The House of the Dead), The Evil Mastermind behind the creation of several Zombies: The Chariot, The Hanged Man, The Hermit, and The Magician.

Caleb Goldman (The House of the Dead 2) was a Mad Scientist who funded Dr. Roy Curien's Research...

...and created The Emperor...

...as well as The World, who is the successor of The Emperor.

Alphys (Undertale) is a Lizard Mad Scientist who is responsible for the creation of Mettaton.

Mad Scientist (Valkyrie Crusade)

Guillaume (Vampire Night) is a Vampire Mad Scientist who was exiled by society for his Unethical/Inhumane Experiments. He has the power to transform into a winged vampire.

Dr. Crygor (WarioWare Series)

Oberst-Gruppenführer Wilhelm Strasse (Wolfenstein), Pure Evil Nazi Mad Scientist and Arch-Enemy to Blazkowicz.

Dr. Schabbs (Wolfenstein 3D)

Apothecary Frye (World of Warcraft)

Chief Plaguebringer Middleton (World of Warcraft)

Doctor Gutrick (World of Warcraft)

Doctor Maleficus (World of Warcraft)

Doctor Razorgrin (World of Warcraft)

Doctor Sabnok (World of Warcraft)

Doctor Sintar Maleficious (World of Warcraft)

Dr. Terrible (World of Warcraft)

Dr. Whitherlimb (World of Warcraft)

Forsaken Blightspreader (World of Warcraft)

Forsaken Plaguesmith (World of Warcraft)

Mad Scientist (World of Warcraft)

Plaguebringer Tillinghast (World of Warcraft)

Professor Putricide (World of Warcraft), Mad Scientist behind all forms of Blight/Plague.

Professor Slate (World of Warcraft)

Scourge Technician (World of Warcraft)

Surgeon Stitchflesh (World of Warcraft)

Warden Stillwater (World of Warcraft)

The Chemist (Zombie Night Terror) was a mad scientist who created a zombie virus. He was later killed by his own creations.

Web Animation/Original/Series

Dr. Bananas (Annoying Orange)

Katz (Monster Lab)

Dr. Emily Gray (Red vs. Blue), Heroic Mad Doctor who once tortured a space pirate for information.

A centuries-old mad doctor, SCP-049-The Plague Doctor (SCP Foundation) is capable of causing all biological functions of an organism to cease through direct skin contact and has experimented on subjects while turning them into zombies while attempting to cure them of what he calls Pestilence.

SCP-1760-Casket Garden/Pyotr (SCP Foundation) Contains the animated remains of Pyotr, A mad mortician responsible for the creation of these animated bodies that come from these caskets.

Doctor Jack Bright (SCP Foundation) is one of the craziest mad scientists in the SCP Foundation.

All scientists at the SCP Foundation (SCP Foundation) will become mad one time or another due to working with all the anomalies/SCPs.

Doc Rex (Screaming Soup!) is a mad scientist that is well versed in all areas of experimentation from biology to robotics and astrophysics.

Dr. Rig R. Mortis MD (Screaming Soup!) is a mad surgeon who finds great satisfaction in committing brutal and unnecessary surgery on others over something as simple as a bruised knee or toothache.

Baxter (The Hazbin Hotel) wants nothing more than to do his Mad Experiment in hell in peace.

Dr. Cochram Block (The Nostalgia Chick/Channel Awesome)

Dr. Coquette Tease (The Nostalgia Chick/Channel Awesome)

Dr. Insano (The Spoony Experiment/Channel Awesome), Mad Scientist who is the Hyde to Spoony's Jekyll.

Linksano (The Spoony Experiment/Channel Awesome) is an alternate universe version of Dr. Insano who is not as mad but still mad.

Other

Mutran (Bionicle), one of many mad scientists that is part of the mad scientist group, The Brotherhood of Makuta.

The Brotherhood of Makuta (Bionicle)

Dr. D. Zaster (Lego Agents), Henchman of Dr. Inferno who tried to cover Lego City in Toxic Slime.

Dr. Inferno (Lego Agents), Arch-Enemy of the Agents who wants to conquer the world

Ogel (Lego Alpha Team)

Crazy Scientist (Lego Minifigures Series 4) certainly lives up to his name.

Mr. Good and Evil (Lego Minifigures Series 9) is a lego version of Mr. Jekyll and Hyde but represents both personalities simultaneously.

Monster Scientist (Lego Minifigures Series 14) is your typical cartoony mad scientist.

The Crazy Scientist (Lego Monster Fighters)

Videos

Archer Best Of Algernop Krieger FX

Ben 10 Introduction of Dr.Animo

Dr. weird compilation (season 2)

Eggman VS Wily (Sonic VS Mega Man) DEATH BATTLE!

Exploring the SCP Foundation Dr. Bright

Goku Meets Dr Gero 1080p HD

HOW2 How to Be a Mad Scientist!

Meet the Medic

Monster Lab EPISODE 1 - The Cooke Jar

Origin of Dr. Bright (SCP Animation)

Professor Farnsworth's best moments

Resident Evil Albert Wesker Explained

SCP-049 illustrated (The Plague Doctor) Updated ft. TheVolgun, Site-42, Dr Cimmerian & Dr Viewless

The Most Wanted Man in Star Wars - Doctor Evazan and His Horrific Crimes - Star Wars Explained

They Might Be Giants - I Am Invisible (official video)