Despite his advanced age, Genryūsai Shigekuni Yamamoto (Bleach) was considered to be the strongest Soul Reaper in existence for the last millennium.
Ichibē Hyōsube (Bleach) is one of the oldest Soul Reapers, possibly older than even Yamamoto, and is also one of the strongest beings in existence.
Yhwach (Bleach) is the first and most powerful Quincy to have ever existed.
Though not as powerful as he was in his prime, even in old age, King Piccolo (Dragon Ball) wields frightening power, easily outmatching Goku and beating him to the point where his heart temporarily stopped.
Despite his advanced age, Master Muten Roshi (Dragon Ball series) is a very skilled and experienced warrior...
... enough to earn the respect of the God of Destruction.
King Bradley/Wrath (Fullmetal Alchemist) is a very powerful swordsman despite his body often feeling the effects of old age.
Walter C. Dornez (Hellsing)
Aged 120, Isaac Netero (Hunter × Hunter) can fight toe-to-toe with the strongest Chimera Ant Meruem.
Zeno Zoldyck (Hunter × Hunter) attempts to assassinate the Phantom Troupe's leader, Chrollo.
Hagoromo Ōtsutsuki, the Sage of Six Paths (Naruto)
Tsunade (Naruto) appears to be a young woman, but she is already in her 50s, using her superhuman strength and a transformation technique to mask her physical appearance.
Despite being 91-years-old, Kakuzu (Naruto Shippuden) is one of the most powerful and dangerous member of the Akatsuki.
Aged 65, Mifune (Naruto) is the Samurai General of the Land of Iron
Despite his old age, Edward "Whitebeard" Newgate (One Piece) was still considered one of the most powerful men in the world before his death.
At the age of 68, Charlotte "Big Mom" Linlin (One Piece) is one of the four most powerful pirates in the world.
Brook (One Piece) is a veteran 90 year old pirate and a master swordsman.
Marine Admirals (One Piece)
While in his late 50s, Kizaru (One Piece) is an extremely powerful Marine Admiral.
Despite being a blind elderly man, Fujitora (One Piece) is an extremely powerful Marine Admiral.
Despite being in his 70, Monkey D. Garp (One Piece) is still considered one of the strongest marines alive.
Kureha (One Piece) is a genius doctor who has lived up to the age of 141.
While over 70 years old, "Dark King" Silvers Rayleigh (One Piece) is still one of the strongest people in the world.
Despite being nearly 80 years old, Sengoku "The Buddha" (One Piece) was a Fleet Admiral of the Marines and one of, if not the strongest amongst their ranks, able to even battle the Blackbeard Pirates by himself.
All Minks (One Piece) are natural born fighter who retain their physical prowess even in old age.
Though elderly, Nekomamushi and Inuarashi (One Piece) are the strongest of the Mink tribe.
Despite being elderly, Hayato Fūrinji (History's Strongest Disciple Kenichi) is a powerful martial artist in prime condition.
Cologne (Ranma ½) looks like a deformed she-gnome, measures her age in centuries rather then years, and can still beat down any two of the teenage martial artists at the same time.
Happosai (Ranma ½) one of the two by-far most skilled characters in the series, and likely easily the most powerful chi-user.
Though not as powerful as she was in her prime, Genkai (Yu Yu Hakusho) remains a formidable fighter.
Despite his old age, Bang (One-Punch Man) is ranked 3 among the strongest of the Hero Association and founder of his own brand of martial arts.
In his life as a Human in his sixties, Uraltugo Noi Nueph (Magi The Labyrinth of Magic) is genius master magician and one of the three Magis of Alma Torran.
Even at age 69, Joseph Joestar (JoJo's Bizarre Adventures Part III Stardust Crusaders) is still a capable fighter, able to hold his own against most Stand Users.
Even at the elderly age of 87, Vasco Strada (Highschool DxD) is still one of the most powerful Exorcists of the Church.
Ou Ki, the Monstrous of Qin (Kingdom)
A Great General of Heavens who displays the physical prowess worthy of the title he holds, Duke Hyou (Kingdom) was the State of Qin greatest Instinctual-type warrior as well as the oldest.
The last surviving member of the previous generation of Zhao's Three Great Heavens, Ren Pa (Kingdom) is a man recognized by all of China as one of the greatest warriors of King Sho's era of warfare and as a Great General of the Heavens who holds the power of 100 men.
One of the most experienced commanders in the entire State of Qin, Chou Tou (Kingdom) is the oldest general in Qin Army having served in the military since the age of 15.
Gai Mou of the Wei Fire Dragons (Kingdom)
Having served in Ganmon stronghold on the Zhao-Xiongnu border over a decade, Ba Nan Ji, the Iron Hammer of Ganmon (Kingdom) is one of the State of Zhao's strongest warriors and serves as Ri Boku's right hand man and deputy.
As a former deputy and Right Hand Man of Rin Shou Jo of Zhao's Three Great Heavens, Gyou' Un (Kingdom) represents over a decade of Zhao martial prowess.
Hades (Fairy Tail) is one of the oldest and most powerful wizards to have ever lived in Earthland.
August (Fairy Tail) is one of the oldest and most powerful member of the Spriggan 12.