The user is a being (mechanical, organic, etc.) created through various artificial means.
Janie (A Certain Scientific Railgun) is a Chemicaloid, an artificial human created from chemicals.
Nemu Kurotsuchi (Bleach) is an artificial entity created by Mayuri Kurotsuchi using Gigai technology and Gikon technology.
Hikone Ubuginu (Bleach) is an artificially made hybrid of Shinigami, Hollow, and Quincy.
Yoshino Soma (Bleach) is one of the Bounts, a group of beings created through a botched Shinigami experiment.
Dawn Summers (Buffy the Vampire Slayer) is an artificial human created through mystical means.
The Venom symbiote (Disney XD's Ultimate Spider-Man) is an artificial lifeform created by isolating the deadliest aspects of Spider-Man's DNA.
Cell (Dragon Ball Z) is a bio-android created by Dr. Gero using the combined DNA of some of the universe's strongest beings.
Cell Max (Dragon Ball Super) is a bio-android based upon Cell's template, created by Dr. Gero's grandson, Dr. Hedo, meant to surpass the original Cell in power.
Inori Yuzuriha (Guilty Crown) is an artificial human specifically created to serve as a host for the spirit of Mana Ouma.
A Soldier (Kingdom Hearts) is just one of the Emblem Heartless, a Heartless created through artificial means.
Grunt (Mass Effect) is an artificial krogan created by Warlord Okeer.
Mitsuki (Naruto/Boruto: Naruto Next Generations) is a synthetic human created by Orochimaru.
Kū (Boruto: Naruto Next Generations) is a synthetic human made by the genes and cells of Ōnoki.
Eveline/E-001 (Resident Evil) is an artifically-created E-type Bio-Organic Weapon.
The T-103 "Tyrant" (Resident Evil) is an elite, mass-produced B.O.W developed by the Umbrella Corporation.
The Nemesis-T Type (Resident Evil) is a variant of the "Tyrants" and one of the most powerful B.O.W.s ever created by the Umbrella Corporation.
Smurfette (The Smurfs), created by Gargamel.
Shadow the Hedgehog (Sonic the Hedgehog)
Biolizard (Sonic the Hedgehog)
Eclipse the Darkling (Archie's Sonic the Hedgehog)
Kull Warriors (Stargate) artificially grown soldiers created by Anubis to replace the Jaffa as his troops. While practically unstoppable on the battlefield, their artificial and disposable nature significantly limits their natural lifespan, even with the Ancient Healing Device being used to keep them alive.
Snoke (Star Wars) was an artificial being created by Darth Sidious using ancient Sith science.
Homunculus (Valkyrie Crusade) is an artificial human.
Adam Warlock (Marvel Comics)
Mewtwo (Pokémon) is a genetically engineered clone of Mew.
Type: Null (Pokémon) is an artificial Pokémon created by splicing the DNA of various species together.
Genesect (Pokémon) is a cybernetically augmented clone of an extinct apex predator.
Chifuyu Orimua (Infinite Stratos) was artificially created to be the ultimate human
Robot Jones (Whatever Happened to...Robot Jones?)
The Ultimen (Justice League Unlimited)
David (Prometheus/Alien Covenant)