XII (Anima: Beyond Fantasy) is one of Crows that survived the Process, a technomagical experiment that replace all subject's blood with an unknown black fluid, granting him supernatural conditions and powers.
Deathstroke (DC Comics) obtained his strength and abilities via experimental Super Soldier.
Clayface (DC Comics)
Bane (DC Comics)
Inque (Batman Beyond)
SOLDIERs (Final Fantasy 7) are all infused with the cells and genes of an extraterrestrial, significantly increasing their overall physiology and condition.
Grunt (Mass Effect) was engineered to be the ultimate krogan super soldier.
Jack (Mass Effect) was experimented on for years to become the most powerful human biotic alive.
Adam (Buffy the Vampire Slayer) is an undead being, a self-described bio-mechanical demonoid, created as part of the 314 Project.
Mercenary Tao Tao Pai (Dragon Ball)
Samus Aran (Metroid)
Quint Lane (Underworld: Awakening) was greatly enhanced through repeated injections of the Corvinus Strain.
Weapon XI/Deadpool (X-Men Origins: Wolverine) was augmented to become the perfect mutant killer.
Shadow the Hedgehog (Sonic the Hedgehog), the end result of Gerald Robotnik's Project Shadow, intended to be the ultimate life form.
Eclipse the Darkling (Archie's Sonic the Hedgehog)
Luke Cage (Marvel Comics) possesses various superhuman physical enhancements after undergoing a Super-Soldier experiment known as the Burstein Process, which was designed to increase his body's cellular regeneration rate.
Captain America (Marvel Comics)
Miguel O'Hara/Spider-Man (Marvel Comics/Marvel 2099)
The T-103 Tyrants (Resident Evil) are cloned humans mutated and augmented through the T-Virus.
The Nemesis-T Type (Resident Evil) is an elite variant of the Tyrant created by further augmenting the T-103 with the NE-α Type parasite.
Experiment 627 (Lilo & Stitch)
Alex Mercer (Prototype) is one of the Evolved, humans augmented by the Blacklight Virus.
James Heller (Prototype 2) an Evolved infected by Mercer.