XII (Anima: Beyond Fantasy) is one of Crows that survived the Process, a technomagical experiment that replace all subject's blood with an unknown black fluid, granting him supernatural conditions and powers.
Deathstroke (DC Comics) obtained his strength and abilities via experimental Super Soldier.
Clayface (DC Comics)
Bane (DC Comics)
Inque (Batman Beyond)
SOLDIERs (Final Fantasy 7) are all infused with the cells and genes of an extraterrestrial, significantly increasing their overall physiology and condition.
Grunt (Mass Effect) was engineered to be the ultimate krogan super soldier.
Adam (Buffy the Vampire Slayer) is an undead being, a self-described bio-mechanical demonoid, created as part of the 314 Project.
Jack (Mass Effect) was experimented on for years to become the most powerful human biotic alive.
Mercenary Tao Tao Pai (Dragon Ball)
Samus Aran (Metroid)
Quint Lane (Underworld: Awakening) was greatly enhanced through repeated injections of the Corvinus Strain.
Weapon XI/Deadpool (X-Men Origins: Wolverine) was augmented to become the perfect mutant killer.
Shadow the Hedgehog (Sonic the Hedgehog), the end result of Gerald Robotnik's Project Shadow, intended to be the ultimate life form.
Eclipse the Darkling (Archie's Sonic the Hedgehog)
Luke Cage (Marvel Comics) possesses various superhuman physical enhancements after undergoing a Super-Soldier experiment known as the Burstein Process, which was designed to increase his body's cellular regeneration rate.
Captain America (Marvel Comics)
Miguel O'Hara/Spider-Man (Marvel Comics/Marvel 2099)
The Nemesis-T Type (Resident Evil 3: Nemesis) was an experimental form of intelligent Tyrant created by the Umbrella via the NE-α Type parasite to follower orders.