Mine (Akame Ga Kill!) wielding Roman Artillery: Pumpkin to great effect, from machine gun to long-range sniping.
Seryu Ubiquitous (Akame Ga Kill!) firing a large volley of heavy artillery for widespread damage.
Beluga J. Heard (Black Cat) wielding Verethragna bazooka with deadly skills, whether for firing or a makeshift hammer.
BG9 (Bleach) has an array of missiles made of spiritual particles, and temporarily had access to Suì-Fēng's Jakuhō Raikōben.
Urzael (Diablo) possesses a powerful cannon that he can use in combat and as a melee weapon.
Dante (Devil May Cry) can wield various artillery to their full potential with his Gunslinger Style.
Rappa Momochi (Gintama) utilizing the powerful Ninja Artillery hidden within her puppet.
Renkotsu (InuYasha) was very skilled with handling and creating all types of artillery of his time, his hand cannon being his signature.
Ginkotsu (InuYasha) was equipped with a large arsenal of heavy artillery thanks to Renkotsu's expertise.
Shen (Kung-Fu Panda) was skilled in artillery, his interest in his family's fireworks led him to create powerful cannons.
Nagato (Naruto) has access to heavy artillery from the Asura Path, such as a chakra cannon or missile launchers.
Franky (One Piece) is very skilled with a large armament of heavy artillery which he installed in his bionic body, from rocket launchers, machine guns...
Tilestone (One Piece) wielding the Demi Cannon that was meant to be installed into battleships as a hand cannon.
Baby 5 (One Piece) using her Buki Buki no Mi powers to transform herself into a large assortment of artillery that she wields efficiently, such as a missile or hand cannon.
The Fire Tank Pirates's (One Piece) great marksmanship skills extends to artillery such as cannons and arm-mounted machine gun.
Genesect (Pokémon) is armed with a cannon, which allows it to fire its Techno Blast, a powerful artillery attack dependent on the drive installed.
Hyōgo Kujiranami (Rurouni Kenshin) became skilled with artillery, replacing his missing right hand with heavy weapons such as the Armstrong Cannon or a customized grenade launcher, both of which he fires with great effects.
Kohran Li (Sakura Wars) is a master of heavy artillery, her preferred weapon being a bazooka.
..can use the Inkzooka, which fires long-ranged tornadoes of ink...
..the Inkstrike, a powerful, remotely guided ink torpedo...
...and the Killer Wail, which unleashes a devastating barrage of sound, all of which resemble artillery, with proficiency.
Agent 3 (Splatoon) can use the Inkzooka with proficiency.
DJ Octavio (Splatoon) can use octorpedoes, rocket fists, the Octarian equivalent of the Killer Wail...
...and octomissiles, all of which resemble artillery, with proficiency.
Wall Eehto (Fairy Tail) creating his Super Long Distance Anti-Material Magic Cannon which has a range of 400 km that reach from the port town of Hargeon to Magnolia.
Issei Hyodou (Highschool DxD) using his Dragon Blaster Beam Cannon to strike Cao Cao with great aim.
Narancia Ghirga's Stand, Aerosmith (JoJo's Bizarre Adventure Part V/5: Golden Wind/Vento Aureo) possessed a wide array of powerful artillery weaponry to destroy its enemies...
...equipped with small machine guns on its wings that fire tracer bullets with infinite amount
...and a single miniature bomb.
Keicho Nijimura's Stand, Bad Company (JoJo's Bizarre Adventure Part IV: Diamonds are Unbreakable)
James "Rhodey" Rhodes/War Machine (Marvel Comics)
Nagumo Hajime's (From Common Job to Strongest in the World) supreme marksmanship includes heavy artillery such as his gatling gun Metzelei...
...and Rocket Launcher Orkan.
Slade Wilson/Deathstroke (DC Comics)
Nathan Summers/Cable (Marvel Comics)
Frank Castle/The Punisher (Marvel Comics)
Tony Stark/Iron Man (Marvel Comics)