Created from humans exposed to various strains of the Forced Evolutionary Virus, Super Mutants (Fallout) are far stronger and tougher than any ordinary human, but are also less intelligent, more agressive, and completely sterile.
Deathclaws (Fallout) are artificially engineered apex-predators.
As a Spartan II, John-117 (Halo) had received extensive augmentations from a young ages to vastly improve his physical and mental attributes.
Ezekiel Stane (Marvel Comics) transformed himself into a biological Iron Man.
Miranda Lawson (Mass Effect) was designed from birth to be a perfect human.
Samus Aran (Metroid) was augmented with Chozo and Metroid DNA at different points.
Kyle Trager (Kyle XY) has undergone sufficient genetic enhancement.