The user can overload a target's biology or biological parts to overload, such as their skeleton, muscles, nervous system, cells, immune system, etc. to become overloaded.
- Muzan Kibutsuji (Demon Slayer: Kimetsu no Yaiba)
- Josh Foley/Elixir (Marvel Comics)
- Estarossa (Nanatsu no Taizai)
- Splicer Serums (DC Animated Universe/Batman Beyond)
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