Despite having lost his eyes as a result of Terrigenesis, Gordon (Agents of S.H.I.E.L.D.) can still see, albeit not like regular people.
Though blind, Vanessa Brewer (Angel) has gone through extensive training that enables her to sense energy sources, body language, and motion in general.
Even though Toph (Avatar: The Last Airbender) was born blind, she feels the vibrations in the earth to know what's happening in her surroundings.
Kaname Tousen (Bleach) was blind from birth, but by training his spiritual senses to perfection he can "see" and fight.
Buffy Summers (Buffy the Vampire Slayer) possesses a heightened awareness of her surroundings, enabling her to navigate and fight even if her opponents are invisible or if she is deprived of her sight.
Tsukuyo Inaba's (Busou Shoujo Machiavellianism) blindness is compensated by immensely sharp hearing.
Despite being blind, Yin (Darker than Black) is a doll that can sense everything, even using her medium to save Hei and play the piano perfectly, even able to walk normally.
Though naturally blind, Doctor Mid-Nite (DC Comics) possesses Infrared Vision
that allows him to see to an extent.
Madame Xanadu (DC Comics)
Even when blinded, Son Goku (Dragon Ball Z) can still fight and navigate using his Chi Detection
, which he demonstrates by dodging Yakon on a planet of total darkness...
...easily killing Eis Shenron after the latter slashed him across the eyes...
...and dodging attacks from Syn Shenron shortly after.
Despite being blinded by Lavender's poison, Gohan (Dragon Ball Super) uses his Ki Sense to block his attacks and keep fighting.
Dementors (Harry Potter) are able to navigate without any eyes.
Suzu Mukai (Horizon In The Middle of Nowhere) is able to use all her other senses in a 360 degree area around her to compensate for her lack of sight.
Blinded by a strike of lightning, Astrid (How To Train Your Dragon) uses her other senses to follow her gut.
N'Doul (JoJo's Bizarre Adventure Part III: Stardust Crusaders)
Riku (Kingdom Hearts) was able to navigate and fight while blindfolded with ease.
After being rendered blind by the growth of fungal plates over their eyes, Clickers (The Last of Us) developed echolocation capabilities to compensate.
Even though he is blind, Matt Murdock/Daredevil (Marvel Comics) is able to perfectly navigate through his surroundings.
When deprived of his sight, Peter Parker/Spider-Man (Marvel Comics) can use his spider-sense to navigate...
...and as a form of Echolocation to detect and fight his opponents.
Mayday Parker/Spider-Girl (Marvel Comics) using her spider-sense to fight and navigate while blindfolded.
Stick (Marvel Comics) was born blind, but attained extraordinary senses through life long training.
Blinding himself to hone his Radar Sense
, Master Izo (Marvel Comics) is a master in the arts of Hand and Chaste Ninjutsu
Ryo Shimazaki (Mob Psycho 100)
Issho/Fujitora (One Piece) has mastered the use of Kenbunshoku/Observation Haki to compensate for his blindness.
Though blind, Lickers (Resident Evil) are perfectly capable of navigating thanks to their super-sensitive hearing.
While she was born blind, Atla (Rising of the Shield Hero) can sense her surroundings to make up for it.
Usui Uonuma (Rurouni Kenshin) has gained the "Mind's Eye" after Shishio blinded him, allowing him superhuman hearing that can act like a sonar, more than compensating his blindness.
Jack (Samurai Jack) has trained to focus and hone his senses, allowing him to fight and navigate while blindfolded.
Despite being born blind, Hattori Tatsu (Teenage Mutant Ninja Turtles 2012 TV series) possesses an acute sense of hearing, bordering on a sixth sense.
Raymond Connor/Daredevil (Ultimate Marvel) developed enhanced senses on par with Matt Murdock's after being blinded in an accident, allowing him to navigate and fight despite his disability just like his predecessor.
Alopex (Teenage Mutant Ninja Turtles)...
...to defeat some Foot ninjas while blindfolded.