Buffy Summers (Buffy the Vampire Slayer) possesses a heightened awareness of her surroundings, enabling her to navigate and fight even if her opponents are invisible or if she is deprived of her sight.
Though blind, Vanessa Brewer (Angel) has gone through extensive training that enables her to sense energy sources, body language, and motion in general.
Dementors (Harry Potter) are able to navigate without any eyes.
Though naturally blind, Doctor Mid-Nite possesses Infrared Vision that allows him to see to an extent.
Riku (Kingdom Hearts) was able to navigate and fight while blindfolded with ease.
Geordi La Forge (Star Trek) uses a special visor to accomplish this end.
Even thought Toph (Avatar: the Last Airbender) is born blind, she feels the vibrations in the earth to know whats happening in her surroundings.