User is an entity completely comprised of a brain or multiple brains, is a disembodied brain in a synthetic body, or they could be completely be formed from brain-matter and/or aspects of the nervous system. This could count as a literal meaning, their physiology looking and behaving just like a regular brain, or this could be symbolic, their physical form a manifestation of their brain.
Gremmy Thoumeaux's (Bleach) true self is a brain in a jar. He uses his powers to create a body for himself.
The Brain of Mensis (Bloodborne) is a grotesque, brain-like entity and a powerful Great One.
The Brain (The Brain) is an alien organism that can psychically tamper with the brains of normal human beings, the creature itself resembling a giant brain.
Brain Pods (Buzz Lightyear of Star Command)
The Brain (DC Comics) truly lives up to his name.
Dr. Wheelo (Dragon Ball Z: The World's Strongest) is a disembodied brain in a robotic body.
At the end of the game, it is shown that all that is left of Ruvik (The Evil Within) is his brain, his mind literally hooked into the main circuits of STEM.
The Invisible Creatures (Fiend Without a Face) are monsters made of pure thought that physically feed on the brains and spinal cords of their victims, their physiologies resembling brains and spinal cords.
The Brain Spawn (Futurama) are living brains with the power to reduce others' intelligence.
The Brains (Jimmy Neutron: Boy Genius) are a race of brain-like aliens with limited psychic powers.
Esidisi (JoJo's Bizarre Adventure Part II: Battle Tendency), after his body was destroyed by Joseph Joestar's Hamon/Ripple.
After his body was destroyed in a bomb blast, Hector Con Carne (Evil Con Carne) was reduced to a sentient brain.
Kenjaku (Jujutsu Kaisen) is a living brain who survives by periodically swapping bodies.
The Aurum Brain (Kid Icarus: Uprising)
The Divine Predecessors (Lexx) are the extracted brains of the former Divine Shadows, retaining all of their memories and knowledge.
Douglas McNoggin (Lloyd in Space), a cerebellian.
Ego (Marvel Cinematic Universe) is a celestial who's true form is a brain, having learned to create a planet and a human form using matter around him.
Mother Brain (Metroid) is an organic supercomputer in the shape of a giant brain.
Aurora Units (Metroid Prime 3: Corruption) are brain-like organic supercomputers used by the Galactic Federation.
After a brutal battle with Samus Aran, Weavel's (Metroid Prime Hunters) brain and spinal cord were placed into a cybernetic body to preserve his life.
Evil Brain (Regular Show)
RoboCop 2 (RoboCop) is operated/powered by the brain of the deceased drug lord Cain.
SCP 1027 - Carnivorous CNS (SCP Foundation)
After repeated injuries at the hands of the Shredder, Baxter Stockman (Teenage Mutant Ninja Turtles) was eventually reduced to a disembodied brain.
The Kraang (Teenage Mutant Ninja Turtles)
Utrom (Teenage Mutant Ninja Turtles)
Mega Brain (Widget The World Watcher) is an artificially created entity known as a Brain Unit.
Brain Golem (Yu-Gi-Oh!)
Tainted Wisdom (Yu-Gi-Oh!)
SCP-1027 Carnivorous CNS (SCP Animation)-2
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