Martel (Fullmetal Alchemist) is half human and half snake.
Bido (FullMetal Alchemist) is half human and half lizard.
Roa (FullMetal Alchemist) is half human and half ox.
Dolcetto (FullMetal Alchemist) half human and half dog.
Ulchi (Fullmetal Alchemist) half human and half crocodile.
Darius (FullMetal Alchemist) is half human and half gorilla.
Heinkel (FullMetal Alchemist) is half human and half lion.
Jerso (FullMetal Alchemist) half human and half toad.
Zampano (FullMetal Alchemist) is half human and half boar/porcupine.
Jabra's (One Piece) half-man half-wolf form.
Absalom (One Piece) was given animal transplants such as, elephants skin, lion jaws and muscles that are a mixture of a bear and gorilla.
Doctor Viper (Swat Kats: The Radical Squadron) was mutated into a half-cat/half-snake creature by a biochemistry experiment gone wrong.
Jefferson Starships (Supernatural) possesses the combined traits and abilities of vampires, wraiths, and shapeshifters.
The White Hybrids (Aliens/Predator: Deadliest of the Species) possess the combined traits of Humans, Xenomorphs, and Predators.
Caleb (Heroes) using his powers.
Connor (Angel) is half-demon half-vampire.
Krik Langstrom/Man-Bat (DC Comics) is half-bat and half-human.
Miguel O'Hara/Spider-Man 2099's (Marvel Comics) genetic code was altered to become half-spider after the machine meant to restore his DNA was sabotaged.
Curt Conners/The Lizard (Marvel Comics) infused himself with Lizard DNA in order to regrow his arm.
Vincent Stegron/Stegron (Marvel Comics) transformed himself into human-stegosaurus hybrid by injecting himself with a modified version of the Lizard Formula.
Tigra (Marvel Comics) was magically transformed into a half-human half-tiger warrior by the Cat People of the Savage Land to save her life from alpha radiation.
Howler Wasps (Dungeons & Dragons) are hybrids of monkeys and bees.
Discord (My Little Pony: Friendship is Magic)
Bugbear (My Little Pony: Friendship is Magic)
Chimera (Teenage Mutant Ninja Turtles 2012 TV series) is part eagle, salmon and worm.
The Labyrinth Clan (Gargoyles)
Monsterex (Teenage Mutant Ninja Turtles Adventures) is a two-headed mix of vampire, werewolf, gillman, mummy, and Frankenstein's monster.
Wikus Van De Merwe (District 9) became Half-Prawn after he was exposed to an alien chemical that fused his DNA with alien DNA.
Zack (Dark Angel) is an X5, a group of twelve human/animal hybrids created by Manticore.
Olcadan (Soulcalibur III) gained the head of an owl after being cursed by a God of War for defeating his messenger owl.
Freed Sellzen (High School DxD)
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Frankencreep (Scooby Doo! Frankencreepy)