Sheele (Akame Ga Kill!) wielding Cutter of Creation: Extase, which is sharp enough to cut through any physical defense, even the impenetrable armor, Incursio.
Train Heartnet (Black Cat) firing an Orichalcum bullet out of Hades, which is capable of destroying any material on Earth.
Baraggan Louisenbairn's (Bleach) time acceleration powers can disintegrate anything from powerful Kido barriers to his own Resurrección enhanced Hierro.
Bambietta Basterbine (Bleach) transforms anything her The Explode power touches into bombs, bypassing any shields and physical defenses.
Moe Shishigawara (Bleach)
Lille Barro's (Bleach) The X-Axis does not use bullets, but simply pierces everything between the muzzle of his rifle and the target, with no barriers in between capable of blocking it.
Wei Zhijun (Darker than Black) can teleport using his blood as catalyst, hence once his blood is on the target, there is no defense.
Nappa (Dragon Ball Z) using his Break Cannon, a powerful mouth energy beam that pierces through the foe's defenses.
Piccolo's (Dragon Ball Z) Special Beam Cannon, when charged enough, can pierce through enemy defenses and foes whose raw strength would ordinarily block Ki attacks...
...and pierces through Babidi's magical barrier.
Yajirobe's (Dragon Ball) Ka-Blam Slicer is a powerful sword beam that penetrates the opponent's defenses.
Laxus Dreyar (Fairy Tail) uses "Mercury Fulminate: Thunder God" to beat an electrically immune Wall Eehto.
Kenshiro (Fist of the North Star) using Hokuto Jūha Zan to harden Heart's skin, allowing him to bypass Heart's body fatty defenses.
Oboro (Gintama) using Hakkei to strike Gintoki's pressure points, causing a disruption of the meridian flow, thus cannot be blocked.
Utsuro (Gintama) using Hakkei to strike Kagura's pressure points, causing a disruption of the meridian flow, which leads to internal damage.
While Issei Hyoudou's (Highschool DxD) Dress Break is generally used for perverted reasons, it can also be used to destroy armor.
Inuyasha (Inuyasha) using Meido Tessaiga to rip apart a Shikon no Tama protected Naraku.
The Shukaku's Pike/Spear of Shukaku (Naruto) is formed from sharpest minerals compressed together, and can pierce through even the Infinite Armor.
Particle Style/Dust Release techniques (Naruto) cannot be blocked, since it will disintegrate any and all matter that it touches.
Using the hammer to add force to the axe, the Bluntsword/Blunt Blade the Helmet Splitter: Kabutowari (Naruto) can cut through all defenses.
The Third Raikage's (Naruto) Thrust of Hell: One Fingered Assault/Hell Stab: One Finger Nukite is his strongest spear, and can pierce through even his own body.
Using the Chidori, Sasuke Uchiha (Naruto) was able to pierce clean through Gaara's sand-based defenses and make him bleed…
…and firing chakra arrows through his Susanoo with such piercing force that no physical defense can block it, especially if he imbues it with the black flames that will incinerate anything they pierce…
…infusing lightning chakra into his blade to enhanced it’s cutting power, allowing him to cut down armoured samurais with ease.
Might Guy's (Naruto) Night Guy technique strikes at such intense power that it distorts the space of his immediate vicinity, bypassing defenses.
Kaguya Ōtsutsuki (Naruto) firing her "All-Killing Ash Bones" with such force that it pierced through Kakashi's "Susanoo".
Aruka Schild (Needless) using Agni Schiwattas to accelerate kinetic movement of molecules, causing combustion that can bypass defense.
As his body is rubber-based, Monkey D. Luffy (One Piece) is able to bypass Enel's electricity-based Logia defense and injure him…
…and later used his Gear Second’s Gum Gum/Gomu Gomu Jet Gatling to smash through Rob Lucci's Tekkai/Iron Body...
...and after 2 years of mastering it, he can use Busoshoku/Armament Haki to break through the strongest of defenses, like the New Fishman Pirates' Steel Shell Formation.
Usopp (One Piece) using an Impact Dial to create a condensed shock wave that bypassed Monkey D. Luffy's rubbery defense.
The Reject Dial (One Piece) possesses the same ability as the Impact Dial, but with 10 times the output that its defense-penetrating power can cause lethal damage, both ways.
Vinsmoke Sanji's (One Piece) Diable Jambe can burn through any defenses, even the iron like defenses of a Tekkai/Iron Body master.
Rob Lucci (One Piece) using Ultimate Radius: Six King Gun/Sai Dai Rin: Rokuogan to produce a powerful shock wave that bypassed Luffy's rubber-based defenses.
Bartholomew Kuma (One Piece) using Pad Cannon/Pad Ho, piercing through every defense and obstacles with high-pressure air blasts.
Marshal D. Teach/Blackbeard (One Piece) can use his Dark-Dark Fruit/Yami Yami no Mi to nullify any Devil Fruit based defenses from Paramecia to Logia, making them more vulnerable to physical harm.
Edward Newgate/Whitebeard (One Piece) using Kabutowari to enhance his punch with vibrations, shattering defenses and causing tremendous damage.
is superior to fire
, Sakazuki/Akainu (One Piece) is able to bypass Ace's Logia defense
and mortally wound him.
Users of Busoshoku/Armament Haki (One Piece)…
Roronoa Zoro (One Piece) mastery of Busoushoku Haki allows him to slice through Haki-enhanced defenses.
By coating his pointed head with Busoshoku Haki, Chinjao (One Piece) performed a headbutt powerful enough to split open the immensely hard ice continent.
The Hasshoken style (One Piece) generates shock waves that can shatter defenses, such as shields and armor.
Trafalgar D. Water Law (One Piece) has mastered his spatial slicing powers to the point he can cut through the hardest physical objects and bypass powerful Haki-based defenses…
…and uses Gamma Knife, which bypasses any defenses to directly rupture the target's internal organs, making it almost impossible to survive.
Charlotte Linlin/Big Mom (One Piece) can easily smash the hardest defenses with her punches.
As a skilled alchemist, Edward Elric (Fullmetal Alchemist) can transmute Greed's skin from graphene to graphite, which allows for his shield to be breached with excessive force.
Jabberwock (Project ARMS) releasing hypersonic vibrations from his body to shatter and disintegrate his victims' molecules, even the vibration-resistant Successors.
Sanosuke Sagara (Rurouni Kenshin) using Mastery of Two Layers, which uses the first strike to nullify an object's resistance, and the second strike (made within 1/75th of a second) easily destroys it.
Levi Kazama's (Trinity Seven) Shadowless Slash technique has an incorporeal edge, meaning her blade does not exist under any physical laws and allows her to bypass barriers.
Shield Crush!!! (Yu-Gi-Oh!)
Penguin Torpedo (Yu-Gi-Oh!) is a Direct Attacker, allowing it to bypass and Wall monsters and attack the opponent directly.
Ectoplasmer (Yu-Gi-Oh!) is a Direct Attack Magic Card, allowing the user to sacrifice their monster to bypass wall monsters...
...or attack-stopping Magic Cards like Nightmare Steel Cage, and directly striking the defenseless opponents.
Byakko (Yu Yu Hakusho) using Meikō Shōkai-Ha to release a densely oscillating scream that can break molecular bonds, meaning it cannot be blocked, only dodged.