The circumstance in which the user is dependent on the regular usage of drugs, devices, etc. to control/retain their powers, stay cognizant, or even to remain alive. Variation of Affinity and Aversion. Opposite to Self Sufficiency and Self-Sustenance.
Sue Storm/The Invisible Woman (Marvel Comics) needs to wear a special suit in order to become completely invisible because her invisibility powers have no effect on normal clothes.
Johnny Storm/The Human Torch (Marvel Comics) needs to wear a special suit that is immune to fire because normal clothes will be burnt when he self-combusts.
In order to use his Bio-Organic Thermokinetic Blasts, Black Tom Cassidy (Marvel Comics) requires a wooden object to focus them through, such as his shillelagh.
Herman Schultz/Shocker (Marvel Comics) designed his costume to withstand the effects of his own Vibration Gauntlets for his own safety as the recoil effect can cause bodily harm, and possibly death without it.
Toothless (How to Train Your Dragon) needs Hiccup to stabilize his new modified tail to fly.
The Werecats (Scooby-Doo on Zombie Island) need to drain life-force from victims every harvest moon.
Despite being immortal, Chase Young (Xiaolin Showdown) needs to drink the Lao Mang Lone Soup every day to retain his human form and to stay young forever.
Demigods (Asura's Wrath) depend on their Mantra reactors to fight.
Frank West (Dead Rising) requires the Zombrex drug to prevent himself from becoming a zombie.
Raziel (Legacy of Kain) must regularly consume souls to maintain his physical body or risk being shunted back to the Spectral Realm.
Quarians (Mass Effect) are dependent on specialized environmental suits because of their near-nonexistent immune systems.
As his new cyborg body lacks self-repair units of its own, Raiden (Metal Gear) must periodically steal fuel cells and batteries from other robots and cyborgs to recharge and heal.
Due in part to their severe psychological trauma, the members of the Beauty and the Beast Unit (Metal Gear Solid 4: Guns of the Patriots) can only survive outside of their suits for a few minutes.
After losing his body's ability to regulate temperature, Python (Metal Gear Solid: Portable Ops) must wear a special cooling suit filled with liquid nitrogen or risk being literally burned alive from the inside out.
Samus Aran (Metroid) depends on her Power Suit to fight aliens.
Without Celebrimbor possessing his body or a Ring of Power to sustain him, Talion (Middle-earth: Shadow of Mordor) will become mortal again and slowly die from the wounds he received on the night of his death.
Shang Tsung (Mortal Kombat) absorbs souls to stay young.
After being severely burned by Kintaro, Kabal (Mortal Kombat) must now wear a breathing mask and mobile life support to remain alive.
Drahmin (Mortal Kombat) needs to wear the Face of Kun-Lo to prevent himself from losing his mind to an oni's mindless rage.
Albert Wesker (Resident Evil) needs to regularly inject himself with a specialized serum to keep the virus inside his body in check.
Due to his small body making him incapable of flying, Arpeggio (Sly Cooper) built a mechanical birdcage on wheels to help him travel.
After suffering irreparable damage to his heart and lungs, Dingo Egret (Zone of the Enders) is forced to remain inside the Orbital Frame Jehuty to preserve his life.
If Reapers (Blade II) don't feed on blood almost constantly, they will starve to death.
Like all vampires, Angel (Buffy the Vampire Slayer) must regularly ingest mammalian blood to maintain his vitality.
Glory (Buffy the Vampire Slayer) needs to periodically drain the sanity of others to maintain her own but to also to keep Ben from gaining control.
Due to a design flaw that renders her brain unable to produce enough serotonin, Max Guevara (Dark Angel) must ingest tryptophan or drink milk in order to avoid losing her powers and/or suffering violent seizures.
Darien Fawkes (The Invisible Man) needs regular injections of a special counteragent or risk being driven insane by the Quicksilver in his system.
Unlike his comic book counterpart, the Abe Sapien of the Hellboy movies must wear a special breathing apparatus when outside of water for prolonged periods.
After losing his immune system, Mason Eckhart (Mutant X) must wear synthetic skin, a white wig, and gloves to avoid infection.
Joshua (No Ordinary Family) requires special injections not only to retain his powers but to stay alive.
Like Joshua, Dr. Dayton King (No Ordinary Family) needs the serum to keep himself alive as well as to resist cancer he had 18 years ago.
After being severely burned on Mustafar, Anakin Skywalker/Darth Vader (Star Wars) was placed into a mobile life support unit to sustain his life.