- "It is said that scattered through Despair's domain are a multitude of tiny windows, hanging in the void. Each window looks out onto a different scene, being, in our world, a mirror. Sometimes you will look into a mirror and feel the eyes of Despair upon you, feel her hook catch and snag on your heart."
- ― Sandman #21: "Season of Mists", preludium
- Despair Incarnate
- The Despairful
- The Hopeless
- The Despairing
- The Gloomy
Users become the living embodiment of despair and gain the ability to feed off of the despair of everyone and everything, including themselves. Users can convert despair into energy and use it as a full source to extend their own life span or as a weapon. They may never age and may be immune to death unless certain conditions are met.
- Without despair the user is weakened.
- Stronger users of Hope Embodiment will be able to overcome the user.
- Nnoitra Gilga (Bleach)
- Kōga Kuchiki (Bleach)
- The Darkness (Chilling Adventures of Sabrina)
- Junko Enoshima (Danganronpa: Trigger Happy Havoc)
- Despair (Vertigo/DC Comics)
- Apocalymon (Digimon)
- Alma Wade (F.E.A.R. Series)
- Close (Go! Princess Precure!); after absorbing Dyspear.
- Bill Dauterive (King of the Hill)
- Alessa Gillespie (Silent Hill)
- Town of Silent Hill (Silent Hill)
- Witches (Puella Magi Madoka Magica)
- Sha of Despair (Warcraft)