"A hand of light to shake the heavens and rend the Earth!!"
― Marshall D.Teach/Blackbeard (One Piece)
"What I seek is not the art of self-defense, but absolute destructive power."
― Genos to Saitama (One-Punch Man)
The power to unmake and destroy anything, everything and everyone to total and utter nothingness. Opposite to Creation.
User can destroy/annihilate into total and utter nothingness anything, everything and everyone, beginning with entire areas, buildings, cities, countries, states, continents, worlds, planets, dimensions, inter-dimensions, parallel worlds, solar systems, stars, star systems, whole entire galaxies nebula's and universes and possibly even abstract concepts and/or natural forces/laws.
Cosmic and high-level possessors of this immeasurably limitless god-like ability can literally go beyond space-time itself, thus wiping out and destroying all that exists in the entire universe and way beyond.
The Living Tribunal (Marvel Comics) only answers the One-Above-All.
Abraxas (Marvel Comics)
The Goblin Entity (Marvel Comics)
The Ultimate Nullifier (Marvel Comics)
Heart of The Universe (Marvel Comics)
The M'Kraan Crystal (Marvel Comics)
Beyonders (Marvel Comics)
When possessed by the Phoenix Force, Jean Grey (Marvel Comics) is strong enough to destroy everything at a molecular level.
Captain Atom (DC Comic) destroys his self-created Universe
The Ogdru Jahad (Hellboy) are destined to bring about the apocalypse.
King Chicken (Duckman) created the Beautex virus, which eats away matter, causing it to devolve through its various stages and then banishing it into nowhere, causing the world to nearly vanish completely.
Dr. Ivo Robotnik (Sonic the Hedgehog) preparing his Ultimate Annihilator, a satellite cannon that can utterly erase matter from reality.
Bender Bending Rodríguez (Futurama) wielding the Planetary Annihilator, which fires a deadly beam with an ever expanding diameter that annihilates all matter.
When Peter Griffin and Ernie (Family Guy) fights, the two always cause massive destruction and many casualties.
Bill Cipher (Gravity Falls)
The Power Gem (Marvel Comics) represents Infinite power and as such can allow its user to destroy anything.
Cat Noir (Miraculous Ladybug) using his Cataclysm on the cover of Le Grand Paris' swimming pool.
Hirose Yuichi's (Alive: The Final Evolution) power, Void, destroys any and all matter it hits.
Accelerator's (A Certain Magical Index) vector manipulating abilities have immense destructive potential, capable of wrecking the planet.
Train Heartnet (Black Cat) firing an Orichalcum bullet out of Hades, which is capable of destroying any material on Earth.
Baraggan Louisenbarn's (Bleach) time acceleration powers can disintegrate anything it touch from Kido Barriers to even his own Resurrección enhanced Hierro.
Anything the edge of Zanka no Tachi (Bleach) touches is eradicated into nothingness.
Ichibē Hyōsube (Bleach) using Futen Daisatsuryō to completely destroy his foes with blackness, that not even their souls can reincarnate.
Kosuke (Btooom!) setting off an Implosion BIM that can shave off all matter via its vacuum explosion.
The Azure Flame (Code:Breaker) will burn everything and anyone to nothingness.
Negation (Code:Breaker) from Pandora's Box is capable of destroying the world outright.
As the God of Destruction, Beerus (Dragon Ball Super) wields the Energy of Destruction, and is powerful enough to annihilate an entire universe should he unleash it all.
Sidra (Dragon Ball Super), the God of Destruction of the Ninth Universe, holding the Energy of Destruction.
Toppo (Dragon Ball Super) surrounding himself with an aura of the Energy of Destruction.
Zeno and his future counterpart (Dragon Ball Super) using Erase that is so absolute and powerful, it can completely annihilate an entire universe and everyone in it that even escaping to another universe is futile.
The black flames of Amaterasu (Naruto) are inextinguishable and are so deadly that they won't stop until they burn down everything to ashes.
Users of Dust Release (Naruto) can create techniques that destroy matter and energy at a molecular level.
Obito Uchiha's (Naruto) Yin-Yang weapons can cause anything but senjutsu to cease to exist.
Mard Geer (Fairy Tail) can use the Memento Mori that is the ultimate curse, erasing one's existence for eternity by removing life and death.
Jabberwock (Project ARMS) is an engine of destruction, with deadly abilities such as raising temperature, electromagnetic railgun, hypersonic vibration, and the deadliest is antimatter production.
Rasen (Flame of Recca) can use the Kōkai Gyoku to erase anything in existence, whether it be physical, mental, or conceptual. In exchange, it takes something of equal value from the user.
Marshall D. Teach/Blackbeard's (One Piece) Dark Dark Fruit/Yami Yami no Mi reduces all to nothing, while his Tremor Tremor Fruit/Gura Gura no Mi destroys all.
Sailor Saturn (Sailor Moon) is the Sailor Soldier of Silence and Destruction. She uses her planetary weapon, the Silence Glaive, to utterly destroy entire worlds and planets.
Miroku (InuYasha) can destroy anything he sucks into his Wind Tunnel/Kazaana.
Ryner (Legend of the Legendary Heroes) is able to analyze and destroy existence.
Izayoi Sakamaki's (Problem Children are Coming from Another World, Aren't They?) gift is Code: Unknown, allow him to destroy anything, even gifts.
...destroys Polnareff's fingers during their fight.
Okuyasu Nijimura's Stand, The Hand (JoJo's Bizarre Adventure Part IV/4: Diamond is Unbreakable)
Clear Note’s (Zatch Bell) spells focus on completely annihilating his opponents. Clear wants to become the mamodo king solely so he can bring genocide to his world. He even believes the destruction of his kind was the very reason he was born.