The user possesses or can develop supernatural powers as a compensation for a disability; for example, if the user is blind, their other senses are enhanced.
Gordon (Agents of S.H.I.E.L.D.) lost his eyes as a result of undergoing Terrigenesis to activate his powers.
Despite being blind, Toph Beifong (Avatar: The Last Airbender) is capable of "seeing" by sensing vibrations.
After losing his sense of touch, Peyton Westlake's (Darkman) body overproduces adrenaline, granting him superhuman strength and immunity to pain.
Having been deliberately raised to interpret body language as a first language, Cassandra Cain (DC Comics) is illiterate and barely able to speak, but as a trade-off, she can intuitively read body language and predict her opponents' attacks.
Due to her prosthetic right eye, Erza Scarlet (Fairy Tail) is immune to such magic as Illusion Magic and Stone Eyes.
Due to his lack of a "Delta brainwave," Philip J. Fry (Futurama) is mentally handicapped, but also immune to psychic powers like Telepathy and Intelligence Reduction.
Due to his blindness and the fact that magic has to be seen and heard for spells to affect people, Jeffrey Robbins (Gargoyles) is immune to magic.
After having his left hand petrified in the shape of a clenched fist, Owen Burnett (Gargoyles) uses it to his advantage to deliver powerful punches.
As he evolved over the centuries, Turel (Legacy of Kain) developed enhanced hearing at the cost of his sight.
Neo's (The Matrix) eyes was damaged during a fight with Smith, but...
...he developed a new perception of sight.
After being blinded by radioactive waste, Daredevil (Marvel Comics) developed superhuman senses and a radar sense to compensate.
After being blinded by Shang Tsung, Kenshi Takahashi (Mortal Kombat) developed telekinetic powers and enhanced senses.
After being blinded by Shishio, Usui Uonuma (Rurouni Kenshin) learned how to compensate using his hearing and spiritual senses.
Clark Kent's (Smallville) super-hearing initially manifested to compensate after he was temporarily blinded.
Having lost their eyes, the Miraluka (Star Wars) have learned to "see" through the Force.
After his mutilation on Mustafar, Darth Vader (Star Wars) became heavily dependent on the Dark Side of the Force to marginalize his wounds, allowing him to be self-sufficient again.
Dezel (Tales of Zestiria) compensated for his blindness by learning to read the wind.
After being rendered blind by the growth of fungal plates over their eyes, Clickers (The Last of Us) developed echolocation capabilities to compensate.