The user can kill a deity/deities or any divine embodiment they may choose to get rid of. They are resistant to the effects of a deity and are capable of killing the specified deity. The user may be a deity with vast or corrupting powers or a being higher than a deity. Because deities are powerful and numerous, it may require instigating a war to kill them all at once.
Stan Smith (American Dad!) threatening god with the heaven gun
Titus (DC Comics) is an alien being of immense power who came to Earth in an attempt to challenge and kill its Gods, something he claimed to have done on numerous other worlds.
Uxas/Darkside (DC comics
Lucifer Mornigstar (DC comics)
Anti-Monitor (DC Comics)
Amatsu MIkabosi (Marvel comics) was be able to kill several deities throughout the universe
The Demorgorge/Atum (Marvel Comics) has power that makes deities seem human by comparison.
equipped with the necrosword, Gorr the gob Butcher (Marvel Comics) start a crusade to kill all the gods of the universe
The Sentry (Marvel Comics) brutally kills Ares, the God of War.
Saint of Killers (Preacher) killing God
Xena's (Xena: Warrior Princess) second pregnancy endowed her with the power to destroy Zeus and the Olympic pantheon.
As an Archangel, Lucifer (Supernatural) can kill or destroy entities like pagan deities....
...and angels like Castiel with ease.
The Olympian Crystal (Once Upon a Time) is so powerful that it is the only thing that could kill a God.
Azrael's Blade (Lucifer) is a weapon powerful enough to kill and eradicate the souls of angels and possibly the Goddess of creation.
The bow and arrows of Artemis (Supernatural) are able to kill deities
Chelia Blendy (Fairy Tail) is a Sky God Slayer, bestowed with the power to heal from injuries and the power to kill a god.
After becoming one with the Universe Seed, Hearts (Dragon Ball Heroes) became the Ultimate Godslayer...
...wielding the power to easily erase Fused Zamasu, an immortal god, from existence.
Orga Nanagear (Fairy Tail) is a Lightning God Slayer, one bestowed with the power to kill a god.
Scathach (TYPe-MOON) possesses the God Slayer skil
Zero (Hardcore Leveling Warrior) summoning God killing weapons via her skill, The Rain of God Annihilation.
Han Sung-Gong's (Hardcore Leveling Warrior) personal attribute, Oedipus, grants him the ability to kill his father and God of Lucid Adventure, Han Gun-Jae.
In addition to his both monstrous strength, Shiba Kyouichi (Shinmai Maou no Keiyakusha) is a user of "Ars Decidium", a special combat form that focuses on the art of killing high-level gods and demons alike.
Hanzo's Armor (Kubo and the Two Strings) - when joined together - is powerful enough to slay Kubo's grandfather the Moon King.
Ragnarok (Valkyrie Crusade) is a WMD that can kill deities.
Ryu Hayabusa (Ninja Gaiden) is a ninja of the Dragon Lineage. Although he his human, he possesses connections to philosophical and spiritual arts. Due to this, Ryu is able to push past his physical limitations, allowing him to defeat supernatural beings and even supreme deities.
Shinbu (Kingdom of Paradise) is a powerful warrior who was able to master all five Sword and Chi Arts of the Five Clans, then learned the San'Yuan in its purest state killing Genbu, Suzaku, Byakko, Seiryu, and Banko.
The Hunter (Bloodborne) was able to kill several Great Ones - Lovecraftian Gods worshiped by the people of Yharnam - with nothing but brute force.
Asura (Asura's Wrath) was not only able to slay the Seven Deities, but was even able to kill Chakravartan, the creator of the Universe.
The Chosen Undead (Dark Souls) was able to slay a pantheon of gods with nothing but his/her shield and a sword.
To be the downfall of Olympus. Because of this, Zeus betrayed him and sent Kratos (God of War) on a path of vengeance and desolation all aimed at the Gods.
Satanael (Persona 5) was able to kill Yaldabaoth, the God of Control, in a single hit of its Sinful Shell.
the scarlet king (SCP foundation)
Spear of the Non-Believer (SCP foundation)
A hero of the Trojan War, Diomedes (Greek Mythology) was capable of wounding gods, driving Aphrodite and Ares away in fear for their lives.