Due to its sheer size, the Colossus Titan (Attack on Titan) has the most raw strength and destrutive power of all Titans, at the cost of being the most taxing on its users stamina.
At the cost of gaining one of the Nine Titan powers (Attack on Titan), a person will be subjected to the Curse of Ymir, granting them only 13 years left to live at most.
Igor Planter (Black Cat) using Tao to control and become plant-life, but he overdosed on the potion that gave him power, killing him.
Gyanza Rujike (Black Cat) using his Tao to enhance his muscles, but due to his lack of training on how to use his ki efficiently, he ended up depleting his life force from overuse and dying.
Those who contract Est (Bladedance of Elementalers) will grant enormous power, but the side effect is when she slay spirits, it passes on the curses and resentment of the sprits slain by her onto her master, and eventually taking the user's life in exchange.
Kokujō Tengen Myō'ō (Bleach) possesses immense physical strength due to its size, but that large size makes is a bigger target, and any damage inflicted will be reflected on its user, Komamura. Komamura's main concept of his Bankai is to utilize its immense destructive force before the opponent can cause any harm in return.
Kokujō Tengen Myō'ō: Dangai Jōe gains the power of immortality and increased agility, but it came at the cost of Komamura offering his physical heart to transform into a human, which when worn off, transformed him into a wolf who only thirsted for revenge.
Genryūsai Shigekuni Yamamoto's (Bleach) bankai, Zanka no Tachi, is immensely powerful, but has the risk of destroying the entire Soul Society and Yamamoto himself if left active for too long.
In his Bankai form, Kenpachi Zaraki (Bleach) gains nigh-incomparable strength, at the cost of becoming a mindless, feral berserker who's body cannot handle it's own power anymore.
Shunsui Kyōraku's (Bleach) Bankai, Katen Kyōkotsu: Karamatsu Shinjū, is very powerful, but does not discriminate between friend and foe and will affect anyone within its radius, even Shunsui himself.
Shinji Hirako's (Bleach) Bankai, Sakashima Yokoshima Happōfusagari, reverses the perception of friend and foe of anyone within its area of effect, including allies, leaving Shinji alone immune to its effects.
Rukia Kuchiki's (Bleach) Bankai, Hakka no Togame, is very powerful, but requires Rukia to slowly deactivate it & thaw at risk of shattering, during which she is all but defenceless.
Ichigo Kurosaki (Bleach) becoming one with Zangetsu and his Inner Hollow for the Final Getsuga Tensho, which would deprive him of his Shinigami powers after.
Giriko Kutsuzawa (Bleach) can use his Time Tells No Lies to set contracts with the God of Time, but cannot undo those once they are set, and can even be affected himself by the Flames of Time if the contract is broken.
Baraggan Louisenbairn (Bleach) can use his Respira to rot anything it touches. However, since this power is absolute he can also be rotted by it should it bypass his defenses.
Yū Otosaka (Charlotte) can absorb the abilities of other ability-users, however for every ability he takes, he loses some of his memory.
By drawing on their Yoki, Claymores (Claymore) can become more and more powerful at the risk of becoming monstrous Awakened Beings…
…as was the fate of Priscilla.
Rei (Code: Breaker) can control the seven flames of hell, at the cost of something, such as his sense of taste and one of his organs.
Bai like all Contractors, (Darker than Black) must fulfill his/her task after using their powers
Arale Norimaki (Dr. Slump) using her signature N'cha Cannon, firing a powerful beam from shouting a greeting, but it is very draining on her power reserves, repeated usage will result her ceasing to function until recharge.
In the Great Ape form, a Saiyan's (Dragon Ball series) power level increases tenfold, but without the proper training, they lose their sense of reason, being reduced to mindless beasts.
Tenshinhan (Dragon Ball Z) using the Kikoho to cause massively powerful strikes, but it is very draining on his life-force, and repeated usage will eventually kill him.
Through the usage of the Kaioken, Goku (Dragon Ball series) can increase his speed, strength, and senses, but multiplying the intensity beyond what he can handle can damage his body and potentially kill him.
The Ultra Instinct transformation gives Goku (Dragon Ball Super) incredible power…
…but its usage eventually caused his body to begin to break down, causing heavy bleeding…
Guldo (Dragon Ball Z) can freeze time, but it only lasts as long as he can hold his breath, and expends a lot of his energy.
Frieza's (Dragon Ball Z) 100% Full Power grants him power, but with the strain on his body, he is not able to fight at maximum capacity for long, slowly weakening.
Frieza's Golden form (Dragon Ball Super) grants vast power, but quickly expends his stamina.
When Trunks (Dragon Ball Z) uses Super Saiyan Third Grade, it grants him strength and power, but the massive muscle increase inhibits his speed.
Ultimate Shenron (Dragon Ball GT) can grant any wish without restriction, but if the Black Star Dragon Balls are not returned to the place of his last summoning within a year's time, the planet on which he was summoned will explode.
Super 17's (Dragon Ball GT) barrier allows him to absorb all energy attacks, however, the pose he makes to create it leaves him vulnerable and doesn't protect him against physical attacks.
When Ultear Milkovich (Fairy Tail) uses the ultimate arc of time magic Last Ages she can rewind time for the entire planet, but in exchange she gives up all her remaining life, completely burning out all the magic in her body and rapidly ageing her into an old woman.
Kyouka (Fairy Tail) can increase the powers of those she targets, if they are not strong enough, she turns them into small paper like figures.
Using the power provided by a concept of Ultear within distorted time, Sherria Blendy (Fairy Tail) is able to use the power of Third Origin to defeat the Time wizard Dimaria Yesta, but at the price of permanently losing the ability to use magic.
Rasen (Flame of Recca) can use the Kōkai Gyoku to erase anything in existence, whether it be physical, mental, or conceptual. In exchange, it takes something of equal value from the user.
After their failed attempt at bringing their mother back to life, Edward and Alphonse Elric (Fullmetal Alchemist: Brotherhood) suffered the backlash of the "Law of Equivalent Exchange," costing Ed his right arm and left leg and Al his entire body. Later at the end of the manga storyline, to fully restore his brother, Ed was forced to sacrifice his ability to perform alchemy as a price.
Dangerous technique from the Ancient Martial Arts, Seidou Goei (History's Strongest Disciple Kenichi) combines the opposing ki of Sei and Dou by focusing the first inward and having the second explode outward.Due to the conflicting nature of the Sei and Dou, extensive use of this technique causes disruption inflow of ki resulting in crippling, even fatal damage.
Miroku's (Inuyasha) Wind Tunnel can devour everything, but it grows in size every year or from damages to the sides, eventually sucking himself in, resulting in death. Also, any poison he sucks in will injure him.
In his full-demon form, InuYasha (Inuyasha) possesses great power, but his demon blood begins to eat away at his sanity and human soul.
While using his Wind Suit technique, Wamuu (JoJo's Bizarre Adventure Part II Battle Tendency) wraps himself in a whirlwind of steam giving him the ability to reflect the sun's rays off his body but only lasting for roughly ten seconds…
…and his Atmospheric Rift, which also uses the tubes for his Wind Suit, can gather huge amounts of air and compresses it in his lungs, however, it slowly tears his body apart given the scraping and heat led by the quick wind compression.
Stands (JoJo's Bizarre Adventure) can grant many advantages, however, any damage inflicted on a Stand will be reflected on their user...
...and If the user doesn't have a fighting spirit to control the Stand it can go out of control and slowly kill the user like a disease.
When Jean Pierre Polnareff's Stand, Silver Chariot (JoJo's Bizarre Adventure Part III Stardust Crusaders) removes its armor, it increases its speed, though makes it more vulnerable to attacks.
DIO's Stand, The World
(JoJo's Bizarre Adventure) can stop time but only for 5 seconds, however, in spite of his Immortality
increasing its power, time would stop for about 9 seconds.
Josuke Higashikata's (JoJo's Bizarre Adventure Part IV Diamonds are Unbreakable) Stand, Crazy Diamond can repair damage and heal injuries of others but it cannot heal its user.
Megumin (Konosuba) has mastered the Explosion spell to the absolute exclusion of any other magic, unfortunately she can only cast it once a day as it completely drains all her magic reserves, leaving her completely helpless and immobile.
Refal (Legend of the Legendary Heroes) wields Glouvil a massive sword with immense destructive power, but in order to unleash this power he must sacrifice something of himself every time its power is used.
Darkness ÄRMs (Marchen Awakens Romance) allow the user to perform curses, but many of these ÄRMs come with risky side effects.
Unlike a true ÄRM which chooses to be partners with its user, Ghost ÄRMs (Marchen Awakens Romance) gradually eat away at their user's life energy.
After receiving critical injuries during his fight with All For One, All Might (My Hero Academia) can only use One For All for three hours straight...
...causing him to revert back to his original appearance. In addition, if he's forced to use it any longer it will strain his body, as well as shorten the time limit on his Quirk.
Denki Kaminari (My Hero Academia) possesses the quirk "Electrification", allowing him to generate electricity
from his body. However, exceeding his wattage limit would short circuit his brain, leaving him temporarily brain dead for an hour.
Mina (My Hero Academia) has a limit of how much acid she can produce, with her skin gradually losing its natural resistance to corrosion.
Having inherited the quirk "One For All" from All Might, Izuki Midoriya (My Hero Academia) is able to stockpile and harness power…
…allowing him to perform physical feats unrivaled by any other quirk-user…
…but due to a lack of control and a feeble body, the power could strain his body to the point that it would break whatever part of the body he used.
Minoru Mineta (My Hero Academia) possesses the quirk "Pop Off", allowing him to remove sticky balls from his head and place them on any surface. Should he do this too much, he eventually starts to bleed.
Rikidou Satou (My Hero Academia) possesses the quirk "Sugar Rush", which allows him to boost his strength by 5 times
for every 10 grams of sugar he consumes. However, when converting sugar into strength, his cognitive functions gradually drop, making him very sleepy afterwards.
Hanta Sero (My Hero Academia) possesses the quirk "Tape", allowing him to eject strips of tape from his elbows. Overuse of this ability eventually leads to dry skin.
Tetsutetsu Tetsutetsu (My Hero Academia) possesses the quirk "Steel", allowing him to turn his body into pure steel. Use of this however causes iron fatigue, eventually weakening his form.
Thirteen (My Hero Academia) has the power to generate black holes
. However, the black holes created are incredibly unstable and could cause immense damage if not regulated properly.
Shouto Todoroki (My Hero Academia) possesses the quirk "Half-Cold Half-Hot" gives the right side of his body the power to generate ice
and his left side to generate fire
. Overuse of one specific power could be detrimental to his body and weaken his attacks, such as the overuse of his ice powers giving him frostbite.
…the darker it is, the more savage and uncontrollable it becomes.
Ochako Uraraka (My Hero Academia) quirk "Zero Gravity", allows her to alter the gravitational weight
of anyone or anything she touches. however…
…overuse causes her to feel severe nausea.
Bakugo's (My Hero Academia) quirk allows him to create explosions via the use of his sweat and ignite them, however, without his specialized bracers, repeated usage of it, particularly large explosions will result in throbbing pain to his arms and shoulders, as well as using both arms at the same time will cause their overall strength to disperse that results in weaker blasts.
Mirio's (My Hero Academia) can phase through solid matter, however, it also makes him phase through his clothes leaving him nude, but when he's fully intangible he can no longer see, hear, or breathe, and can only experience a falling sensation because he still has mass.
Shota (My Hero Academia) can nullify anyone's quirk by looking at them, though he needs to blink occasionally and overusing it will give him bad dry eye, as well as if anything obstructs his sight, and doesn't work on Mutant-type quirks.
The Akimichi's Secret Triple Threat/Three-Colored Pills (Naruto) converts calories into chakra to make it easier to use their calorie control abilities, but are poisonous and the conversion leaves the user potentially lethally emaciated.
Being a non-Uchiha and not possessing their Enhanced Body
, Kakashi Hatake (Naruto) suffers even more stress and fatigue from his overusing of the Sharingan
than any Uchiha using it.
Upon opening all eight inner gates Might Guy (Naruto) nearly died from the side-effects with his body nearly turning to ash
before Naruto saved him by stabilizing his life force, though his final technique Night Guy
forced him to retire from active duty due to permanent damage to his right leg.
Mizuki (Naruto) using an experimental cursed seal that gave him animal traits with explosive power, but the strain destroyed his cells and nearly killed him.
Tsunade's (Naruto) Mitotic Regeneration/Creation Rebirth Technique shortens her natural lifespan.
The more Itachi Uchiha (Naruto) uses his Mangekyō Sharingan, the more his eyesight will deteriorate…
…and accelerate his disease.
Sasuke Uchiha (Naruto) activating the Heavens’ Curse Mark/Cursed Seal of Heaven to gain an increase in chakra and power, but extended usage will corrode his mind from Orochimaru's, causing him to go mad.
After receiving half of Hogoromo Ōtsutsuki's chakra, Sasuke Uchiha (Naruto) awakened the Rinnegan, allowing him to use all the Six Paths Jutsu, ability to travel through dimensions and swap places, however if overused each tomoe vanish and he becomes considerably weakened.
In his four-tailed form and onwards, Naruto Uzumaki (Naruto) possesses great strength, but the Nine-Tailed Fox's chakra constantly destroys and regenerates his skin, shortening his life.
With the use of Izanagi and Izanami techniques, a Sharingan user (Naruto) will lose sight in their eye forever.
Devil Fruits (One Piece) can grant whoever consumes them a unique, life-long power, at the cost of no longer being able to swim at all.
Kuro (One Piece) can move at blinding speed, however, he can't clearly see who he attacks, given said, his remorseless towards his crew says otherwise.
Overtaking the Rumble Ball (One Piece) can cause Tony Tony Chopper's Devil Fruit powers to go haywire, and even force him to expend his life force. After the timeskip he only needs one Rumble Ball to enter his Monster Point, and while he can now control himself, it still expends his life force requiring rest afterwards.
Before mastering it, Monkey D. Luffy's (One Piece) Gear Second technique would increase his strength and speed, but cause immense strain on his body and potentially shorten his lifespan…
…and Gear Third - Bone Bullon, which increases his strength, however, brings about shrinking upon deactivation…
…and while using Gear Fourth - Bounceman, which greatly enhances his strength and speed similar to what both Gear Second or Gear Third individually grant...
...but it also overuses his Busoshoku Haki, leaving him temporarily unable to use it for ten minutes once he reaches his limit, and also immensely taxes his body and stamina, leaving him exhausted and barely able to move after it wears off.
Despite the advantage of being able to cancel out other Devil Fruit powers via physical contact, Marshall D. Teach/Blackbeard (One Piece) is more susceptible to pain than anyone else because of the gravity-based nature of the Yami Yami no Mi of drawing things in, which is the fruit's only notable weakness, even though is classified as a Logia.
The Mink Tribe (One Piece) Sulong transformation grants them undisputed power and fighting ability during the fullmoon, at the cost of higher brain function and their stamina. Running the risk of burning out their life force if activated for too long.
Capone Bege (One Piece) feels any damage done to him in his Big Father form and should it be destroyed, he will die.
Trafalgar D. Water Law (One Piece) can lift ships, cut or swap/switch places of people/objects, even give someone eternal youth at the cost of the users life, however...
...the Ope Ope no Mi itself shortens one lifespan if overused and depletes the user stamina to the point of causing him to collapse...
...and if the ROOM space is much bigger it might cause his lifespan to shorten faster to the point of near-death state.
Using Meteoric Burst, Boros (One-Punch Man) boosts his capabilities beyond their limits, but doing so fatigues his body and potentially shortens his lifespan.
Garo/Garou (One Punch Man) had also started to break his own limiter just like Saitama, and as a result was starting to lose his humanity and became a monster.
Saitama (One Punch Man) gained access to virtually unlimited power after breaking his natural limiter by going through a brutal training regime for three whole years, but at the cost of his hair, his ability to feel emotions (somewhat) and suffering chronic unotability in spite of his impressive strength.
When Pryce (Pokémon Adventures) forced Celebi to travel back in time, it adversely caused temperature dropping to absolute zero and the world completely freezing.
In her Iron Maiden form, Ruby Tojo (Rosario + Vampire) has great magical power, but the more she moves, the more the suit tightens around her body, causing physical damage.
In his Ghoul form, Tsukune Aono (Rosario + Vampire) possesses great vampiric powers, but at the cost of his sanity.
Yukishiro Enishi (Rurouni Kenshin) using his Frenzied Nerves to greatly amplify his five senses and reflexive speed, but it causes him to discard defense in exchange.
Kazuma (s-CRY-ed) is able to use his Shell Bullet Ultimate, but the cost of straining his right arm to the point where all feeling is lost.
Usagi Tsukino better known as Sailor Moon (Sailor Moon) with Legendary Silver Crystal tremendous power, capable of reviving an entire world from ruin but the strain of using such power often costs the user her life - as the power actually derives from the life force of the Moon dynasty, the members of which alone can actually use it.
Sailor Saturn (Sailor Moon) is the Sailor Soldier of Silence and Destruction. She uses her planetary weapon, the Silence Glaive, to utterly destroy entire worlds and planets. However doing so will kill her as well.
By using the skill「Wrath」, Wrath/Sasajima Kyouya (So I'm a Spider, So What?) can multiple all his stats by a factor of 5, but overuse and not possessing the「Heresy Nullity」skill will cause him to go berserk.
Ruki (Senyu) can create dimensional portals that can transport anyone anywhere, but doing so will cause the targets ribs to break every time.
When in Mover Mode, Cosmo's species (Sonic X) obtain vast power, but it causes them to expend their life force, and extensive usage is fatal.
Due his lack of control, Hiei (Yu Yu Hakusho) burnt and almost lost his hand after using the Dragon of the Darkness Flame.
Younger Toguro (Yu Yu Hakusho) gets terribly hungry in his 100% form, requiring him to instinctively absorb souls constantly to maintain his form…
…and if forcing himself past his 100%, reaching 120%, which led to his body to ultimately break down from strain.
Riou’s (Zatch Bell!) curse allows him to drain people’s life energy. However using the curse, puts great strain on Riou’s body, especially if used on many people.
Being aligned with the Archangel Gabriel, Acqua of the Back (Toaru Majutsu no Index) is able to suppress Misha Kreutzev angel powers by 50% after absorbing half of it's Telesma...
...however he lost all his saint powers and abilities and lays at death's doorstep.
The Curse Series (Rising of the Shield Hero) have the highest stats among the 4 Holy Hero weapons and the strongest attacks as well. But they have many side effects and downsides with the most noticeable being they corrupted the Hero's mind and heart.
The Ros-series Heart Hybrid Gears (Hybrid × Heart Magias Academy Ataraxia) are superior to other Heart Hybrid Gears because the use the pilots life-force to increase their abilities, meaning the pilot will die if their Hybrid count reaches zero.