Trait:Double-Edged Power

Double-Edged Power
In his Wrath form, Asura (Asura's Wrath) is immensely powerful, but the fires of his rage actually burn his flesh and begin to tear his own body apart to the extent that his attacks actually cause more damage to himself than his opponents.
Condition to:	Possess immense power at a price.

"It's a double-edged sword...The fighting technique could cost them their life."

― Brook on the Mink's Sulong Form (One Piece)

"If this power of yours is truly absolute, then naturally, you too should be vulnerable to it..."

― Hachigen Ushōda (Bleach)

"All magic comes with a price!"

― Rumpelstiltskin (Once Upon a Time)

The circumstance in which the user possesses great strength and ability at a cost. Not to be confused with Aversion.

Also Called

• Double-Edged Sword
• Faustian Powers
• Flesh for Bones
• Power at a Cost/Price

Capabilities

The user possesses great skill and power, but prolonged usage of it may come at a cost. Overuse or misuse of said power may result in, among other things, insanity and physical damage to the user's body.

Variations

• All-Out Force Charge
• Antithetical Force Manipulation
• Overburst Power
• Power-Based Disability
• Sacrificial Protection
• Suicidal Attack

Associations

• Concept-Dependent Immortality
• Double-Edged Arts
• Feral Mind
• Higher Consciousness
• Life Conversion
• Power Manifestations
• Self-Harm Empowerment
• Singular Power Use

Limitations

• Some double-edged powers may affect people other than the user.
• They may require something to keep their limits restrained.
• With enough training, they may be able to overcome their limitations.
• Overuse may result in critical injury, madness or death depending on the nature of the power.

Known Users

See Also: Power At A Price and Desperation Attack, Equivalent Exchange.

Anime/Manga/Manhwa

• Julie Sigtuna (Absolute Duo)
• Titan-Shifters (Attack on Titan); via Curse of Ymir
• Dark Schneider (Bastard!!); via Judas Pain
• Untrained Tao Users (Black Cat)
• Est Contractors (Bladedance of Elementalers)
• Baraggan Louisenbairn (Bleach)
• Bounts (Bleach); via Dolls
• Sajin Komamura (Bleach); via Humanization Technique
• Giriko Kutsuzawa (Bleach)
• Ichigo Kurosaki (Bleach); via being controlled by his Inner Hollow and Mugetsu
• Several Shinigami (Bleach); via Bankai
• Uryū Ishida (Bleach); via Quincy: Letzt Stil
• Hatsuna Wakabayashi (Brynhildr in the Darkness)
• Kanade Sakurada (Castle-Town Dandelion)
• Denji (Chainsaw Man); via his Chainsaw Devil form
• Shunsuke Otosaka (Charlotte)
• Yuu Otosaka (Charlotte)
• Claymores (Claymore)
• All Ability Users and Rare Kinds (Code:Breaker)
• Kurumi Tokisaki (Date A Live)
• Contractors except Hel (Darker than Black); they're required to perform a task in order to use their powers
• Death Note Users (Death Note)
• Humans who make a deal for Shinigami Eyes (Death Note)
• Frieza (Dragon Ball series); via 100% Full Power and Golden Frieza (initially)
• Guldo (Dragon Ball series)
• Saiyans (Dragon Ball series); via Great Ape Form and Super Saiyan 3
• Son Goku (Dragon Ball series); via Kaio-Ken and Ultra Instinct (initially)
• Future Trunks (Dragon Ball series); via Super Saiyan Third Grade
• Tienshinhan (Dragon Ball series); via Kikoho
• Ultimate Shenron (Dragon Ball GT)
• Granolah (Dragon Ball Super); after becoming the strongest in the universe
• Gas (Dragon Ball Super); after becoming the strongest in the universe
• Rebecca Bluegarden (Edens Zero); via overuse of Cat Leaper
• Users of Law (Fairy Tail)
• Acnologia (Fairy Tail); after ingesting the Time Rift
• August (Fairy Tail); via Ars Magia
• Users of Iced Shell and Lost Iced Shell (Fairy Tail)
• Kyouka (Fairy Tail)
• Natsu Dragneel (Fairy Tail); via eating etherion's ethernano and Fire Dragon King Mode
• Sherria Blendy (Fairy Tail); via Third Origin
• Ultear Milkovich (Fairy Tail); via Last Ages
• Practitioners of Hokuto Ryu Ken/Big Dipper Lapis Lazuli Fist (Fist of the North Star)
• Alchemists (Fullmetal Alchemist); via Human Transmutation
• Vessels of The Torch (Hero Killer)
• Issei Hyoudou (High School DxD); via Juggernaut Drive
• Seidou Goui Users (History's Strongest Disciple Kenichi)
• Toori Aoi (Horizon In The Middle of Nowhere); via getting sad/upset will cause death
• Sakuma Jirou (Inazuma Eleven); via Emperor Penguin no01 causes bone and muscle tissues to break down after 2nd use
• Genda Koujirou (Inazuma Eleven); via Beast Fang, causes bone and muscle tissues to break down after 2nd use
• Inuyasha (InuYasha); via becoming full demon
• Miroku (InuYasha); formerly via Wind Tunnel
• Eucliwood Hellscythe (Is This a Zombie?); when she heals someone, she feels the pain inflicted. Talking gives reality warping powers but headaches.
• Mahoro Andou (Mahoromatic)
• Wamuu (JoJo's Bizarre Adventure Part II: Battle Tendency); via Final Mode: Atmospheric Rift
• Some Stand Users (JoJo's Bizarre Adventure); if the user doesn't have a fighting spirit
• Domain Expansion Users (Jujutsu Kaisen)
• Priestess Dance Users (Kingdom)
• Ohma Tokita (Kenganverse); via his "Advance" technique
• Various Demons (Konjiki no Gash Bell!); via casting certain spells
• Riou (Konjiki no Gash Bell!); via performing his family's curse.
• Megumin (Konosuba)
• Refal (Legend of the Legendary Heroes)
• Tigre Vorn (Madan no Ou to Vanadis); via The Black Bow
• Kōta Shibaki (Majmoji Rurumo); via Wish Tickets
• Darkness ÄRM users (Marchen Awakens Romance); via the side effects most Darkness ÄRMs have
• Ghost ÄRM users (Marchen Awakens Romance); via the life force that is drained every time a Ghost ÄRM is used
• Torch Vessels (Hero Killer); via Power Overload
• Various Quirk users (My Hero Academia)
  • Users of "One For All"
• Yoite (Nabari no Ou); via the Kira Technique
• Creation Rebirth users (Naruto)
• Cursed Seal users (Naruto)
• Eight Gates users (Naruto)
• Akimichi Clan (Naruto); via Three Colored Pills
• Jinchuriki (Nauto); via their initial Jinchuriki forms
• Kakashi Hatake (Naruto); via his Sharingan (initially)
• Mizuki (Naruto); anime only
• Uchiha Clan (Naruto); via Izanagi and Izanami
• Itachi Uchiha (Naruto); via his Mangekyō Sharingan
• Sasuke Uchiha (Naruto); via the Cursed Seal of Heaven (formerly), his Mangekyō Sharingan, and his Rinnegan
• Naruto Uzumaki (Naruto); via his initial Jinchuriki forms and Baryon Mode
• Mitsuki (Naruto/Boruto: Naruto Next Generations); via continuous use of Sage Mode
• Isshiki Otsutsuki (Boruto: Naruto Next Generations); in Jigen’s body
• Eve Neuschwanstein (Needless); via Doppelganger's energy use
• Negi Springfield (Negima! Magister Negi Magi) via Magia Erebea
• Various Devil Fruit users (One Piece)
  • Mansherry; via overuse of the Chiyu Chiyu no Mi restoration power
  • Marco; via overuse of Tori Tori no Mi, Model: Phoenix healing power
  • Marshall D. Teach/Blackbeard; more susceptible to pain via gravity-element drawback
  • Monkey D. Luffy; via Gear Second & Gear Third (pre-timeskip), Gear Fourth - Boundman, Haoshoku Haki (pre-timeskip) and Gear Fifth
  • Nico Robin
  • Tony Tony Chopper; over-dosage of the Rumble Ball (pre-timeskip) and (post-timeskip) Rumble Ball only needed to use Monster Point; later additional side-effects after the improved Rumble Ball time limit
  • Trafalgar D. Water Law; via overuse of Ope Ope no Mi
  • Charlotte Linlin/Big Mom; via Soru Soru no Mi power-up
  • Bartholomew Kuma (One Piece); via transference of pain/suffering with the Nikyu Nikyu no Mi
  • Awakened Devil Fruit Users; via inexperience
• Lunarians (One Piece)
• Minks (One Piece); via Sulong transformation
• Tsumegeri Guards (One Piece); via Hero Water
• Boros (One Punch Man)
• Limiter Breakers (One Punch Man)
• Gene Starwind (Outlaw Star); via use of #4, #9, and #13 Caster Shells
• Aun Freya (Photon: The Idiot Adventures)
• Celebi (Pokémon Adventures); from forced time travel
• Niebel (Rave Master); via Last Moment
• Naofumi Iwatani (The Rising of the Shield Hero); via Blutopfer/Blood Sacrifice
• Tsukune Aono (Rosario + Vampire)
• Ruby Tojo (Rosario + Vampire); via Iron Maiden
• Yukishiro Enishi (Rurouni Kenshin)
• Kazuma (s-CRY-ed)
• Refined Alters (s-CRY-ed)
• Sailor Moon (Sailor Moon); via the Legendary Silver Crystal
• Sailor Saturn (Sailor Moon); using her full destructive and deathly powers also causes her to perish
• Ruki (Senyu)
• Maka Albarn and Soul Evans (Soul Eater) using the black blood can risk them falling into madness and becoming deranged at the cost of using its power.
• Adam (Shuumatsu no Valkyrie: Record of Ragnarok); via overusing "Eye of the Lords"
• Zeus (Shuumatsu no Valkyrie: Record of Ragnarok); via Adamas form
• Meliodas (The Seven Deadly Sins); via his Revenge Counter technique
• Ten Commandments (The Seven Deadly Sins); via their signature Commandments
• Escanor (The Seven Deadly Sins); as "The One Ultimate"
• Acqua of the Back (Toaru Majutsu no Index); via absorption half of Misha Kreutzev Telesma
• Shana (Shakugan No Shana); via Tenpa Josai
• Lina Inverse (Slayers); via Giga Slave
• Kumoko/Shiraori (So I'm a Spider, So What?)
• Wrath/Sasajima Kyouya (So I'm a Spider, So What?)
• Males of Cosmo's species (Sonic X); in Mover Mode transformation
• Hrotsvit Lesedrama (Swordsman of Magic Technique School and Summoned Vasreus)
• Users of the "Swan Song" (Symphogear)
• Half-Humans (Tokyo Ghoul)
  • Kishou Amira
  • Ching-Li Hsiaso
• Toriko (Toriko); via his Original Appetite Demon
• Masane Amaha (Witchblade)
• Moroha (Yashahime: Princess Half-Demon); via using Izayoi's makeup
• Byakko (Yu Yu Hakusho)
• Hiei (Yu Yu Hakusho); via using the Dragon of the Darkness Flame
• Younger Toguro (Yu Yu Hakusho)
• Lestion (Yumekui Merry); firing his gun

Cartoons/Comics

• Mozenrath (Aladdin: The Animated Series); via Gauntlet
• Anne Boonchuy (Amphibia); via her Calamity powers
• Sasha Waybright (Amphibia); via her Calamity powers
• Marcy Wu (Amphibia); via her Calamity powers
• Avatars (Avatar series); via the Avatar State
• Shredder (Batman vs. Teenage Mutant Ninja Turtles)
• Gwen Tennyson (Ben 10 series)
• Heat Jaws (Ben 10 series)
• Danny Fenton/Phantom (Danny Phantom); formerly
• Darkwing Duck (Darkwing Duck); via former use of Super Speed powers
• Bruce Wayne/Batman (DC Comics); via the Hellbat armor.
• Speedsters (DC Comics); via Speed Force
• Kid Psycho (DC Comics)
• Thaddeus Sivana (DC Comics)
• Clark Kent/Kal-El/Superman (DC Comics); via Solar Flare, later Kryptonite energy infusion
• Henry Clover Jr./Gotham (DC Comics)
• Claire Clover/Gotham Girl (DC Comics)
• Lord Commander (Final Space)
• Spark (Girl Genius); there's a reason it's called The madness place.
• Ace (Justice League Unlimited)
• Miraculous holders (Miraculous: Tales of Ladybug & Cat Noir)
• Some Akumatized villains (Miraculous: Tales of Ladybug & Cat Noir)
• Mar-Vell/Captain Marvel (Marvel Comics)
• Guido Carosella/Strong Guy (Marvel Comics)
• Wielders of the Ebony Blade (Marvel Comics)
• Zombie Spider-Man (Marvel Comics)
• Eda Clawthorne (The Owl House); via her curse
• Lilith Clawthorne (The Owl House); after sharing the curse with Eda
• Emperor Belos/Philip Wittebane (The Owl House)
• Mewman (Star vs. the Forces of Evil); via the Solarian Metamorphosis ritual
• Heavyman/Dr. Koenig (Static Shock)
• Eli Shane (Slugterra)
• Maul (WildStorm)

Folklore/Mythology

• King Midas (Greek Mythology)

Literature

• Dark Wizards (Harry Potter); especially when creating Horcruxes
• Mundanes (Shadowhunter Chronicles); via Lilith's blood
• Spirit Users (Vampire Academy/Bloodlines)
• Fanoxean (The Young Guardians)
• Witchers (The Witcher)

Movies

• Bagi (Bagi, the Monster of Mighty Nature)
• The Five Family Members (The Covenant)
  • Chase Collins
  • Caleb; after his ascension.
• Godzilla (Godzilla)

Live Television

• Griffin Grey (Arrowverse)
• Willow Rosenberg (Buffy the Vampire Slayer)
• Cordelia Chase (Buffy the Vampire Slayer/Angel)
• Dr. Curtis Williamson (Charmed)
• Hiro Nakamura (Heroes)
• Peter Petrelli (Heroes)
• Sylar (Heroes)
• Magic Users (Once Upon A Time)
• Castiel (Supernatural)
• Users of the Mark of Cain (Supernatural)
• Sam Winchester (Supernatural); via Demon Blood

Video Games

• Asura (Asura's Wrath); via his Wrath Form
• ADAM users (BioShock)
• Ragna the Bloodedge (Blazblue)
• Non-Belmont users of the Vampire Killer (Castlevania)
• Power Within Users (Dark Souls)
• Centaur Warrunner (Dota 2)
• Blood Mages (Dragon Age)
• Crusader (Final Fantasy VI)
• Users of Para-Magic (Final Fantasy VIII)
• Users of the "Eyes of Etro" (Final Fantasy XIII-2)
• Azura (Fire Emblem Fates)
• Sora (Kingdom Hearts); via Anti-Form and Rage Form
• Donald Duck (Kingdom Hearts); via Zettaflare
• Raziel (Legacy of Kain)
• Secret Stone Users (The Legend of Zelda: Tears of the Kingdom); by swallowing it to become a Dragon
• Mega Man (Mega Man); via Double Gear system.
• Users of Phazon-Enhancement Devices (Metroid Prime 3: Corruption)
• Samus Aran (Metroid); via Metroid DNA
  • Metroid Suit (Metroid Dread)
• Fire God Liu Kang (Mortal Kombat); after regaining his power as Keeper of Time
• Pokémon that know "Perish Song" (Pokémon)
• Pokémon that know recoil inflicting attacks (Pokémon)
• Albert Wesker (Resident Evil)
• Zephyr (Resonance of Fate)
• Lord Genichiro (Sekiro: Shadows Die Twice)
• Metal Sonic (Sonic the Hedgehog); via V. Maximum Overdrive Attack
• Shadow the Hedgehog (Sonic the Hedgehog); without Inhibitor Rings
• Claudio Serafino (Tekken); via the Spear of Kephalos
• Sieg (TYPE-MOON/Fate/Apcrypha); via Dead Count Shapeshifter
• Shirou Emiya (TYPE-MOON); after fusing with Archer's arm
• Shiki Tohno (TYPE-MOON/Tsukihime)
• Infeliz (Valkyrie Crusade)
• Users of the Void (Warcraft series)
• Deathwing (World of Warcraft)

Web Comics

• Che Heart (Ordeal)
• Anton King (Ordeal)
• Garen (Skylark)

Known Objects

Anime/Manga/Manhwa

• The Berserker Armor (Berserk)
• Bakkōtō (Bleach)
• Enrakyōten (Bleach)
• Most Cursed Tools (C3: CubexCursedxCurious)
• Ros-series Heart Hybrid Gears (Hybrid × Heart Magias Academy Ataraxia)
• Locacaca Fruits (JoJo's Bizarre Adventure Part VIII: Jojolion)
• Wish Tickets (Majimoji Rurumo)
• Darkness ÄRMs (Marchen Awakens Romance)
• Ghost ÄRMs (Marchen Awakens Romance)
• Mobile Suits equipped with Trans-Am (Mobile Suit Gundam 00)
• Akimichi Three-Colored Pills (Naruto)
• Hero Water (Naruto)
• Devil Fruits (One Piece)
• Energy Steroids (One Piece)
• Hero Water (One Piece)
• Reject Dials (One Piece)
• Rumble Balls (One Piece)
• Curse Series of the Legendary Hero Weapons (Rising of the Shield Hero)
• Cybernetics (Cyberpunk: Edgerunners)
• Silver Crystal (Sailor Moon)
• Black Blood ("Soul Eater")
• Crown Series Gollems (In Another World with my Smartphone)

Cartoons/Comics

• Mozenrath's Gauntlet (Aladdin: The Animated Series)
• Telecephaloscope (Blake and Mortimer - The Yellow "M")
• The Red Sweater of Courage (Dave the Barbarian)
• The Memory Gun (Gravity Falls)
• Ebony Blade (Marvel Comics)
• Miraculouses (Miraculous: Tales of Ladybug & Cat Noir)
• Alicorn Amulet and Inspiration Manifestation spell book (My Little Pony: Friendship is Magic)
• The Sword of Tengu (Teenage Mutant Ninja Turtles 2003 TV series)
• Sonic's Mech Suit (Sonic Boom)

Literature

• Soulcutter (Book of Swords)
• One Ring (The Lord of the Rings)

Live Television/Movies

• Infinity Gauntlet (Marvel Cinematic Universe)
• Darkhold (Marvel Cinematic Universe), prolonged use of the Dark Magic in this book causes profound corruption in the soul of the user.
• All-Black the Necrosword (Marvel Cinematic Universe)
• The Mark of Cain (Supernatural)
• Equalizer/Hammurabi (Supernatural)
• Hazard Trigger (Kamen Rider Build)
• GeizRevive Ridewatch (Kamen Rider Zi-O)

Video Games/Visual Novels

• Beast Spear (Breath of Fire III)
• Red Lyrium (Dragon Age)
• Boots of Blinding Speed (The Elder Scrolls III: Morrowind)
• Kōkai Gyoku (Flame of Recca)
• Secret Stones (The Legend of Zelda: Tears of the Kingdom)
• Double Gear System (Mega Man 11)
• Phazon Enhancement Device (Metroid Prime 3: Corruption)
• Rejuvenating Waters (Sekiro: Shadows Die Twice)
• Vulture's Artificial Wings (Spider-Man PS4)
• Archer's Arm (TYPE-MOON/Fate/stay Night)
• Dead Count Shapeshifter (TYPE-MOON/FateApcrypha)

Web Animation/Comic/Series/Original

• SCP-427 - Lovecraftian Locket (SCP Foundation)
• SCP-596 - Cursed Regeneration Statue (SCP Foundation)
• SCP-1015 - Poor Man's Midas (SCP Foundation)

Known Powers

• Project Daycare (American Dad!)
• Quincy: Letzt Stil (Bleach)
• Valhalla's Gate (Cautious Hero)
• Demon Slayer Mark (Demon Slayer: Kimetsu no Yaiba)
• Magic (Disney: Twisted-Wonderland); via Blot
• Kaioken (Dragon Ball series)
• Lucid Gadget (Dream Eater Merry); when used in reality.
• Dark Magic (Marvel Cinematic Universe), via the Darkhold
• Angel Zafkiel (Date A Live)
• Law (Fairy Tail)
• Third Origin (Fairy Tail)
• Tao (Hell’s Paradise: Jigokuraku)
• Priestess Dance (Kingdom)
• Mangekyō Sharingan (Naruto)
• Last Moment (Rave Master)
• Sunshine (The Seven Deadly Sins)
• Blastor Mode (Tekkaman)
• Magic (Skylark)
• Bloodlust (Skylark)
• The Void (Warcraft series)
• Cyber corruption (Sonic the Hedgehog)

Gallery

Anime/Manga/Manhwa

Due to its sheer size, the Colossus Titan (Attack on Titan) has the greatest raw strength and destructive power of all Titans, at the cost of being the most taxing on its user's stamina.

A person can gain one of the Nine Titan powers (Attack on Titan) at the cost of being subjected to the Curse of Ymir, granting them only 13 years left to live at most.

Whenever Guts (Berserk) uses the Berserker Armor to become an unstoppable and monstrous beast capable of slaughtering Apostles with ease, but the more he uses it the more damages it does to him even permanent damages even his friends can’t heal.

Igor Planter (Black Cat) used Tao to control and become plant-life, but he overdosed on the potion that gave him power, killing him.

Gyanza Rujike (Black Cat) used his Tao to enhance his muscles, but due to his lack of training on how to use his ki efficiently, he ended up depleting his life force from overuse and died.

Those who contract Est (Bladedance of Elementalers) are granted enormous power, but the side effect is when she slays spirits, it passes on the curses and resentment of the sprites slain by her onto her master and eventually taking the user's life in exchange.

Baraggan Louisenbairn (Bleach) can use his Respira to rot everything it touches into nothingness. However, since this power is absolute, he can also be rotted away by it should it bypass his defenses.

The Tsunayashiro Clan's hereditary Zanpakutō, Enrakyōten (Bleach) allows the wielder to utilize any Zanpakutō powers they have witnessed but drains their lifespan so long as they continue to use it.

Genryūsai Shigekuni Yamamoto's (Bleach) Bankai, Zanka no Tachi, is immensely powerful but has the risk of destroying the entire Soul Society and Yamamoto himself if left active for too long.

Giriko Kutsuzawa (Bleach) can use his Time Tells No Lies to set contracts, but cannot undo those once they are set, and can even be affected himself by the Flames of Time if the contract is broken.

Ichigo Kurosaki (Bleach) becoming one with Zangetsu and his Inner Hollow for the Final Getsuga Tensho, which would deprive him of his Shinigami powers after.

In his Bankai form, Kenpachi Zaraki (Bleach) gains nigh-incomparable strength, at the cost of becoming a mindless, feral berserker whose body cannot handle its own power anymore.

Rukia Kuchiki's (Bleach) Bankai, Hakka no Togame, is very powerful, but requires Rukia to slowly deactivate it and thaw at the risk of shattering, during which she is all but defenseless.

Sajin Komamura's (Bleach) bankai, Kokujō Tengen Myō'ō, possesses immense physical strength due to its size, but that large size also makes it a bigger target, and any damage inflicted will be reflected on its user, Komamura...

...And through the humanization technique, Komamura gains immortality and his Bankai changes into Kokujō Tengen Myō'ō: Dangai Jōe, which possess increased agaility compared to its previous state. However, this comes at the cost of Komamura offering his physical heart to transform into a human and when the effect wears off, he is transformed into a normal wolf.

Shinji Hirako's (Bleach) Bankai, Sakashima Yokoshima Happōfusagari, reverses the perception of friend and foe of anyone within its area of effect, including allies, which can cause any allies aorund him to turn against him.

Shunsui Kyōraku's (Bleach) Bankai, Katen Kyōkotsu: Karamatsu Shinjū, is very powerful, but does not discriminate between friend and foe and will affect anyone within its radius.

Being aligned with the Archangel Gabriel, Acqua of the Back (Toaru Majutsu no Index) is able to suppress Misha Kreutzev angel powers by 50% after absorbing half of its Telesma...

...however he lost all his saint powers and abilities and lays at death's doorstep.

Yū Otosaka (Charlotte) can absorb the abilities of other ability-users, however for every ability he takes, he loses some of his memory.

By drawing on their Yoki energy, Claymores (Claymore) can become more and more powerful at the risk of becoming monstrous Awakened Beings…

…as was the fate of Priscilla...

Rei (Code:Breaker) can control the seven flames of hell, at the cost of something, such as his sense of taste and one of his organs.

Bai like all Contractors, (Darker than Black) must fulfill his/her task after using their powers.

Arale Norimaki (Dr. Slump) using her signature N'cha Cannon, firing a powerful beam from shouting a greeting, but it is very draining on her power reserves, repeated usage will result her ceasing to function until recharge.

Humans who possess a Death Note can perform the Shinigami Eye Trade (Death Note), the Shinigami who is paired with the human who has a Death Note can offer the said human their eyes, allowing them to see the name and remaining lifespan of any human-like a Shinigami would...

...but in exchange for the eyes the human's lifespan will be reduced in half, even if they forgo ownership of the Death Note they will lose the Shinigami eyes, but their lifespan won't be restored.

Kurumi Tokisaki (Date A Live) Angel Zafkiel grants her time manipulation as well as shadows, but the downside of her Angel that each bullet used consumes her time which is her life force, which can be seen in the clock in her left eye.

Frieza's (Dragon Ball series) 100% Full Power allows him to use his maximum output, but with the strain on his body, he is not able to fight at maximum capacity for long, slowly weakening...

...and his Golden form grants vast power, but quickly expends his stamina.

Guldo (Dragon Ball Z) can freeze time, but it only lasts as long as he can hold his breath and expends a lot of his energy.

In their Oozaru/Great Apes form, a Saiyan's (Dragon Ball series) power level increases tenfold, but without the proper training, they lose their sense of reason, being reduced to mindless beasts.

Through the usage of the Kaio-ken, Son Goku (Dragon Ball series) can increase his speed, strength, and senses,...

...but multiplying the intensity beyond what his body can handle will damage his body and potentially kill or cripple him...

...and while the Ultra Instinct transformation gives goku incredible power…

…its continued usage eventually caused his body to begin to break down, causing heavy bleeding…

…and intense pain.

Super 17's (Dragon Ball GT) barrier allows him to absorb all energy attacks, however, to activate it, he has to use a certain pose which leaves him vulnerable to physical attacks.

Tenshinhan (Dragon Ball series) using the Kikoho to cause massively powerful strikes, but it is very draining on his life-force, and repeated usage will eventually kill him.

When Trunks (Dragon Ball series) uses Super Saiyan Third Grade, it increases his strength and power, but the massive muscle increase inhibits his speed severely.

Ultimate Shenron (Dragon Ball series) can grant any wish without restriction, but if the Black Star Dragon Balls are not returned to the place of his last summoning within a year's time, the planet on which he was summoned will explode.

Kyouka (Fairy Tail) can increase the powers of those she targets, if they are not strong enough, she turns them into small paper like figures.

Using the power provided by a concept of Ultear within distorted time, Sherria Blendy (Fairy Tail) is able to use the power of Third Origin to defeat the Time wizard Dimaria Yesta, but at the price of permanently losing the ability to use magic.

When Ultear Milkovich (Fairy Tail) uses the ultimate arc of time magic Last Ages she can rewind time for the entire planet, but in exchange she gives up all her remaining life, completely burning out all the magic in her body and rapidly ageing her into an old woman.

Known as an evil martial art, Practitioners of Hokuto Ryu Ken/Big Dipper Lapis Lazuli Fist (Fist of the North Star) drive the risk of going mad with blind bloodlust if they use the Matōki no Aura, a special type of Ki that grants the user inhuman powers at the cost of consuming their soul, turning them into a "demon".

Rasen (Flame of Recca) can use the Kōkai Gyoku to erase anything in existence, whether it be physical, mental, or conceptual. In exchange, it takes something of equal value from the user.

After their failed attempt at bringing their mother back to life, Edward and Alphonse Elric (Fullmetal Alchemist: Brotherhood) suffered the backlash of the "Law of Equivalent Exchange," costing Ed his right arm and left leg...

...and Al his entire body. Later at the end of the manga story line, to fully restore his brother, Ed was forced to sacrifice his ability to perform alchemy as a price.

A dangerous technique from the Ancient Martial Arts, Seidou Goei (History's Strongest Disciple Kenichi) combines the opposing ki of Sei and Dou by focusing the first inward and having the second explode outward. Due to the conflicting nature of the Sei and Dou, extensive use of this technique causes disruption inflow of ki resulting in crippling, even fatal damage.

The Ros-series Heart Hybrid Gears (Hybrid × Heart Magias Academy Ataraxia) are superior to other Heart Hybrid Gears because the use the pilot's life-force to increase their abilities, meaning the pilot will die if their Hybrid count reaches zero.

Miroku's (InuYasha) Wind Tunnel can devour everything, but it grows in size every year or from damages to the sides, eventually sucking himself in, resulting in death. Also, any poison he sucks in will injure him.

In his full-demon form, InuYasha (InuYasha) possesses great power, but his demon blood begins to eat away at his sanity and human soul.

While using his Wind Suit technique, Wamuu (JoJo's Bizarre Adventure Part II Battle Tendency) wraps himself in a whirlwind of steam giving him the ability to reflect the sun's rays off his body, but only lasting for roughly ten seconds…

…and his Atmospheric Rift, which also uses the tubes for his Wind Suit, can gather huge amounts of air and compresses it in his lungs. However, it slowly tears his body apart given the scraping and heat caused by the quick wind compression.

While Stands (JoJo's Bizarre Adventure) can grant many advantages, any damage inflicted on a Stand will be reflected on their user...

...and if the user doesn't have a fighting spirit to control the Stand, it can go out of control and slowly kill the user like a disease.

When Jean Pierre Polnareff's Stand, Silver Chariot (JoJo's Bizarre Adventure Part III: Stardust Crusaders) removes its armor, it increases its speed, though makes it more vulnerable to attacks.

Megumin (Konosuba) has mastered the Explosion spell to the absolute exclusion of any other magic, unfortunately she can only cast it once a day as it completely drains all her magic reserves, leaving her completely helpless and immobile.

Tokita Ohma (Kenganverse) using his Advance technique risking internal damage and organ failure in the process.

Riou (Konjiki no Gash Bell!) can drain the life energy from humans who fall prey to his family's curse. However, the curse puts great strain on Riou's body, especially if used on many people.

Known as his "Top Gear" spell, Fifusu Naguru pushes Ted's (Konjiki no Gash Bell!) strength and speed to the limit. However, he rarely uses the spell since it gradually destroys his body when he attacks.

While using their Priestess Dance (Kingdom),...

...a Shiyuu swordswoman can instantly kill an opponent with incredible ease and enhanced their already powerful strength to incredible levels ...

...however, the technique can rapidly drain a practitioner's stamina...

...and the longer a practitioner continues to use the technique, the harder the recoil effect on their body.

Refal (Legend of the Legendary Heroes) wields Glouvil a massive sword with immense destructive power, but in order to unleash this power he must sacrifice something of himself every time its power is used.

Darkness ÄRMs (Marchen Awakens Romance) allow the user to perform curses, but many of these ÄRMs come with risky side effects.

Unlike a true ÄRM which chooses to be partners with its user, Ghost ÄRMs (Marchen Awakens Romance) gradually eat away at their user's life energy.

After receiving critical injuries during his fight with All For One, All Might (My Hero Academia) can only use One For All for three hours straight...

...causing him to revert back to his original appearance. In addition, if he's forced to use it any longer it will strain his body, as well as shorten the time limit on his Quirk.

Denki Kaminari (My Hero Academia) possesses the quirk "Electrification", allowing him to generate electricity from his body. However, exceeding his wattage limit would short circuit his brain, leaving him temporarily brain dead for an hour.

Mina (My Hero Academia) has a limit of how much acid she can safely produce, with her skin gradually losing its natural resistance to corrosion.

Having inherited the quirk "One For All" from All Might, Izuku Midoriya (My Hero Academia) is able to stockpile and harness power,...

...allowing him to perform physical feats unrivaled by any other Quirk-user,...

...but due to a lack of control and a feeble body, the power can strain his body to the point that it would break whatever part of the body he used.

Minoru Mineta (My Hero Academia) possesses the quirk "Pop Off", allowing him to remove sticky balls from his head and place them on any surface. Should he do this too much, he eventually starts to bleed.

Rikidou Satou (My Hero Academia) possesses the quirk "Sugar Rush", which allows him to boost his strength by 5 times for every 10 grams of sugar he consumes. However, when converting sugar into strength, his cognitive functions gradually drop, making him very sleepy afterwards.

Hanta Sero (My Hero Academia) possesses the quirk "Tape", allowing him to eject strips of tape from his elbows. Overuse of this ability eventually leads to dry skin.

Tetsutetsu Tetsutetsu (My Hero Academia) possesses the quirk "Steel", allowing him to turn his body into pure steel. Use of this however causes iron fatigue, eventually weakening his form.

Thirteen (My Hero Academia) has the power to generate black holes. However, the black holes created are incredibly unstable and could cause immense damage if not regulated properly.

Shouto Todoroki (My Hero Academia) possesses the quirk "Half-Cold Half-Hot" gives the right side of his body the power to generate ice and his left side to generate fire. Overuse of one specific power could be detrimental to his body and weaken his attacks, such as the overuse of his ice powers giving him frostbite.

Fumikage Tokoyami (My Hero Academia) possesses the quirk "Dark Shadow", which allows him to summon his shadow as a creature to fight for him. The more light there is, the more passive it is…

…the darker it is, the more savage and uncontrollable it becomes.

Ochako Uraraka (My Hero Academia) quirk "Zero Gravity", allows her to alter the gravitational weight of anyone or anything she touches. however,…

…overuse causes her to feel severe nausea.

Katsuki Bakugo 's (My Hero Academia) quirk allows him to create explosions via the use of his sweat and ignite them, however, without his specialized bracers, repeated usage of it, particularly large explosions will result in throbbing pain to his arms and shoulders, as well as using both arms at the same time will cause their overall strength to disperse those results in weaker blasts.

Mirio Togata/Lemillion's (My Hero Academia) can phase through solid matter, but is becomes incapable of seeing, hearing, or breathing when he is fully intangible and can only experience a falling sensation because he still has mass. In addition, he will also phase through his clothes, leaving him nude.

Shota Aizawa/Eraserhead (My Hero Academia) can nullify anyone's quirk by looking at them, though he needs to blink occasionally and overusing it will give him bad dry eye. His powers also don't work if anything obstructs his sight and cannot affect Mutant-type quirks.

Dabi's Quirk (My Hero Academia) allows him to create powerful flames that are said to surpass Endeavor's Quirk, however, since he is born with his mother's resistance to freezing temperatures, his body will burn from overusing it and preventing him from fighting in prolonged battles.

Nine's (My Hero Academia) Quirk to manipulate the weather was deemed "godlike" but repeated usage caused cellular degeneration, and it only worsened when he obtained a copied version of All For One.

The Akimichi Clan's Secret Triple Threat/Three-Colored Pills (Naruto) converts calories into chakra to make it easier to use their calorie control abilities but are poisonous and the conversion leaves the user potentially lethally emaciated.

Being a non-Uchiha and not possessing their body, Kakashi Hatake (Naruto) suffered even more stress and fatigue from his overusing of the Sharingan than any Uchiha using it.

Upon opening all eight inner gates, Might Guy (Naruto) nearly died from the side-effects with his body nearly turning to ash before Naruto saved him by stabilizing his life force, though his final technique Night Guy forced him to retire from active duty due to permanent damage to his right leg.

Mizuki (Naruto) using an experimental cursed seal that gave him animal traits with explosive power, but the strain destroyed his cells and nearly killed him.

Tsunade's (Naruto) Mitotic Regeneration/Creation Rebirth Technique shortens her natural lifespan.

In his four-tailed form and onwards, Naruto Uzumaki (Naruto) possesses great strength, but the Nine-Tailed Fox's chakra constantly destroys and regenerates his skin, shortening his life.

The more Itachi Uchiha (Naruto) uses his Mangekyō Sharingan, the more his eyesight deteriorated…

…and accelerated his disease.

Sasuke Uchiha (Naruto) could gain an increase in chakra and power by activating the Heavens’ Curse Mark/Cursed Seal of Heaven, but extended usage caused his mind to corrode.

After receiving half of Hagoromo Ōtsutsuki's chakra, Sasuke Uchiha (Naruto) awakened the Rinnegan, allowing him to use all the Six Paths Jutsu, ability to travel through dimensions and swap places,

...however if overused each tomoe will vanish and considerably weaken him.

With the use of Izanagi and Izanami techniques, a Sharingan user (Naruto) will lose sight in their eye forever.

Mitsuki's (Naruto/Boruto: Naruto Next Generations) Sage Mode increases his speed tremendously, ethereal snakes appear around his body to aid in his attack range allowing him to grab and bite opponents and use powerful jutsu's. However, he can't sustain his Sage Mode for a long time as it breaks his body, to the point of deterioration, requiring several new organs to recover.

Devil Fruits (One Piece) can grant whoever consumes them a unique, life-long power, at the cost of no longer being able to swim at all.

Kuro (One Piece) can move at blinding speed but can't see who he attacks clearly. However, his remorselessness towards his crew suggests otherwise.

Overtaking the Rumble Ball (One Piece) can cause Tony Tony Chopper's Devil Fruit powers to go haywire, and even force him to expend his life force. After the timeskip he only needs one Rumble Ball to enter his Monster Point, and while he can now control himself, it still expends his life force requiring rest afterwards.

Before mastering it, Monkey D. Luffy's (One Piece) Gear Second technique would increase his strength and speed, but cause immense strain on his body and potentially shorten his lifespan…

…and Gear Third - Bone Bullon, which increases his strength, ...

...however, brings about shrinking upon deactivation…

…and while using Gear Fourth - Bounceman, which greatly enhances his strength and speed similar to what both Gear Second or Gear Third individually grant...

...it also overuses his Busoshoku Haki, leaving him temporarily unable to use it for ten minutes once he reaches his limit, and also immensely taxes his body and stamina, leaving him exhausted and barely able to move after it wears off.

Having partaken of the Yami Yami no Mi, Marshall D. Teach/Blackbeard (One Piece) can not only transform into darkness, but also cancel out the powers of other Devil Fruit users via physical contact...

...However, as a draw-back to this ability, he became more susceptible to pain than anyone else because of the gravity-based nature of darkness drawing things in, even though the fruit is classified as a Logia.

The Energy Steroids (One Piece) doubles the user's power temporarily...

...but accelerates their aging per pill.

The Mink's (One Piece) are granted undisputed power and fighting ability during the full moon due to the Sulong transformation, at the cost of higher brain function and their stamina. Running the risk of burning out their life force if activated for too long.

Capone Luke Bege (One Piece) feels any damage done to him in his Big Father form and should it be destroyed, he will die.

Trafalgar D. Water Law (One Piece) can lift ships, cut or swap/switch places of people/objects, even give someone eternal youth at the cost of the user's life, however...

...the Ope Ope no Mi itself shortens one's lifespan if overused and depletes the user stamina to the point of causing him to collapse...

...and if the ROOM space is much bigger it might cause his lifespan to shorten faster to the point of near-death state.

While Marco's (One Piece) Phoenix healing powers allow him to heal even more serious injuries, overusing this power, such as from extended prolonged use, will eventually affect Marco's Stamina, leaving him weakened and unable to fight from exhaustion.

While giving Nico Robin (One Piece) great versatility, the Hana Hana no Mi has the unique weaknesses of having any damage to their sprouted body parts transferred to their real body. This not only includes injury or strain, but negative affects like poisons or transformations.

Using Meteoric Burst, Boros (One-Punch Man) boosts his capabilities beyond their limits but doing so fatigues his body and potentially shortens his lifespan.

Garou (One Punch Man) had also started to break his own limiter just like Saitama, and as a result was starting to lose his humanity and became a monster.

Saitama (One-Punch Man) gained access to virtually unlimited power after breaking his natural limiter by going through a brutal training regime for three whole years, but at the cost of his hair, his ability to feel emotions (somewhat) and suffering chronic unotability in spite of his impressive strength.

While he has no issues when using his regular Caster Shells, Gene Starwind (Outlaw Star) can put his life in danger when he uses the three most powerful shells (4, 7, and 13) as they can drain his life force each time, he fires one of them, to where he only uses them as a last resort.

When Pryce (Pokémon Adventures) forced Celebi to travel back in time, it adversely caused temperature dropping to absolute zero and the world completely freezing.

The Curse Series (Rising of the Shield Hero) have the highest stats among the 4 Holy Hero weapons and the strongest attacks as well. But they have many side effects and downsides with the most noticeable being they corrupted the Hero's mind and heart.

In her Iron Maiden form, Ruby Tojo (Rosario + Vampire) has great magical power, but the more she moves, the more the suit tightens around her body, causing physical damage.

In his Ghoul form, Tsukune Aono (Rosario + Vampire) possesses great vampiric powers, but at the cost of his sanity.

Yukishiro Enishi (Rurouni Kenshin) using his Frenzied Nerves to greatly amplify his five senses and reflexive speed, but it causes him to discard defense in exchange.

While Escanor (Seven Deadly Sins) can normally only sustain his "The One" form for one minute at noon, he can keep it active for longer by sacrificing his own life span in return, becoming "The One Ultimate".

Kazuma (s-CRY-ed) is able to use his Shell Bullet Ultimate, but the cost of straining his right arm to the point where all feeling is lost.

Usagi Tsukino better known as Sailor Moon (Sailor Moon) with Legendary Silver Crystal tremendous power, capable of reviving an entire world from ruin but the strain of using such power often costs the user her life - as the power actually derives from the life force of the Moon dynasty, the members of which alone can actually use it.

Sailor Saturn (Sailor Moon) is the Sailor Soldier of Silence and Destruction. She uses her planetary weapon, the Silence Glaive, to utterly destroy entire worlds and planets. However, doing so will kill her as well.

By using the skill 「Wrath」, Wrath/Sasajima Kyouya (So I'm a Spider, So What?) can multiple all his stats by a factor of 5, but overuse and not possessing the「Heresy Nullity」skill will cause him to go berserk.

Ruki (Senyu) can create dimensional portals that can transport anyone anywhere but doing so will cause the targets ribs to break every time.

Lina Inverse (Slayers) can cast the spell Giga Slave, which destroys anything in its way as well as bring the Lord of Nightmares into the world. However, if casted improperly, the spell can destroy the entire world and be at the mercy of the Lord of Nightmares. Even if the spell is properly casted, it puts an enormous strain on her as well as turning her hair white temporarily.

When in Mover Mode, Cosmo's species (Sonic X) obtain vast power, but it causes them to expend their life force, and extensive usage is fatal.

Half-Humans, such as Kishou Amira (Tokyo Ghoul), are gifted with enhanced physical capabilities at the cost of a shortened life span.

Byakko (Yu Yu Hakusho) can absorb spiritual energy, whether intentional or not, but there is a limit how much he can absorb and store in, resulting him "popping" once he reaches the limit.

Due to his lack of control, Hiei (Yu Yu Hakusho) burnt and almost lost his hand after using the Dragon of the Darkness Flame.

Each Crown series Gollems (In Another World with my Smartphone) have its own special ability that they offer to their master. However, their master has to pay in equal value depending on the model, such as blood, consciousness, sanity, age, or memory.

Younger Toguro (Yu Yu Hakusho) gets terribly hungry in his 100% form, requiring him to instinctively absorb souls constantly to maintain his form...

...and if he forces himself past his 100%, reaching 120%, his body will ultimately break down from strain.

Cartoons/Comics

As a result of his usage of his magical gauntlet, Mozenrath's (Aladdin: The Animated Series) right hand was stripped of all skin and flesh, leaving the only animated bone. Furthermore, the gauntlet also drained his life force, dooming him to a premature demise.

Hayley Smith (American Dad!) was trained through Project Daycare into an unstoppable sleeper agent, but the flaw is that if she is activated for 7 days consecutively, she would malfunction and turn on her handler (her father Stan).

Due to still being connected to the blue stone of the Calamity Box, Anne Boonchuy (Amphibia) can gain incredible powers, but brings her fatigue whenever she uses, and a time limit for how much she can use it before it fades.

In the Avatar State, the Avatar (Avatar: The Last Airbender/The Legend of Korra) is at their most powerful, but should the Avatar be killed in this state, the cycle of reincarnation will be broken, and the Avatar will cease to exist.

Gwen Tennyson (Ben 10: Alien Force)

Michael Morningstar (Ben 10) can absorb energy, however, this can backfire on him as it can also work in reverse when he contacts to someone he has already drained, and when he absorbs more energy his "hunger" grows with his powers as energy from normal people will not sustain Michael for long, putting him in need of larger amounts.

The Telecephaloscope (Blake and Mortimer) allows one to control the target's Mega Wave, granting them superhuman strength,…

…but if received without a Mega Receiver helmet, the target will be disintegrated by the high energy.

Before managing to overcome this drawback, whenever Danny (Danny Phantom) used his most powerful attack the Ghostly Wail it would drain his energy extremely quickly, forcing him to revert back to his powerless human form, making him vulnerable to his enemies who might potentially be immune to it.

The Red Sweater of Courage (Dave the Barbarian) is able to grant the wearer limitless courage at the cost of their common sense.

To restore his powers after his cells were mutated by Vandal Savage to prevent him from absorbing Yellow Solar radiation, Superman (DC Comics) was forced to use Kryptonite as Chemotherapy that gave him incredible power and eventually restored his original powers, though it also affected his healthy cells which left him terminally ill, and ultimately cost him his life.

The zombie Spider-Man (Marvel Comics) can use his own veins and arteries as makeshift webbing, but doing so causes him intense pain despite being a zombie.

Bane (DC Comics) uses a Super-Steroid called Venom that gives him super strength, but using it consistently causes him to grow an addiction for it.

Trixie (My Little Pony: Friendship is Magic) was given untold powers from the magic, Alicorn Amulet, but the more she used it, the more it corrupted her.

Rarity got new magic and is corrupted by the Inspiration Manifestation spell book (My Little Pony: Friendship is Magic).

Miraculouses (Miraculous: Tales of Ladybug & Cat Noir) are pieces of jewelry imbued with great magic and grant those who wield them with great power. However, using the Miraculouses' special powers causes the person wearing them to only have a limited time before transforming back…

...Ladybug's Lucky Charm...

...Cat Noir's Cataclysm,...

...Rena Rogue's Mirage,...

...Carapace's Shell-ter,...

...Queen Bee's Venom,...

…even Hawk Moth after corrupting in spite of being able to maintain his transformation longer than Ladybug and Cat Noir.

When using a Miraculous that has been damaged, it requires more energy to sustain the kwami which results fatigue and health problems for the holder from overusing it, as in the case with the Peacock Miraculous...

...Emilie Agreste once used it that put her in an eternal slumber...

...and when Nathalie Sancoeur used it as Mayura, it resulted in her health deteriorating and later dying in front of Ladybug.

When someone welds the Ladybug & Black Cat Miraculouses (Miraculous: Tales of Ladybug & Cat Noir) at the same time they will be granted a single wish. However, due to the universe needing to maintain a state of balance, there is a reaction to every wish granted. If someone wishes for something, then that thing will be lost from another person.

Since Copycat's (Miraculous: Tales of Ladybug & Cat Noir) powers is similar to Cat Noir's, he also has a time limit after using Cataclysm

As Antibug's (Miraculous: Tales of Ladybug & Cat Noir) powers are almost similar to Ladybug's, she only has a limit time after using Anti-Charm.

Animan's (Miraculous: Tales of Ladybug & Cat Noir) animal shapeshifting powers can tire him out when he does too often.

The Ebony Blade (Marvel Comics) shares a link with its wielder and any evil acts committed by the wielder can taint the blade.

Heavyman/Dr. Koenig (Static Shock) went through an experiment that enables him to absorb mass, however, it also developed a "hunger" to satisfy it, and the more mass he absorbs the heavier he will get that eventually led him to become immobile to his literal downfall.

Because the Sato-oshi strike (Batman vs. Teenage Mutant Ninja Turtles) concentrated all of the attacker's energy into a single strike, it is potentially as deadly for the attacker as the victim.

Emperor Belos/Philip Wittebane (The Owl House) formed glyphs on his arm to control magic directly, but the combinations made his flesh and physique morph violently, requiring him to absorb the souls of palismen to alleviate the pain and to keep him from transforming...

...in doing so, the souls of the absorbed palismen are trapped in his mindscape, resulting in Belos having frequent outbursts.

Solaria Butterfly (Star vs. the Forces of Evil) invented the "Solarian Metamorphosis" ritual to transform an army of Mewman peasants into "Solarian Warriors" imbuing them with magic, enhancing their physical attributes, and making them fearless...

...however, the ritual deteriorates one's mind, as it made Mina Loveberry insane and being the only surviving warrior, as the other Solarian warriors destroyed themselves because it.

Sonic, corrupted by his Mech Suit (Sonic Boom).

The Memory Gun (Gravity Falls) can erase certain memories, but repeated usage results in minor brain to total memory loss and eventual insanity...

Old Man McGucket.jpg...Fiddleford McGucket, who created it, used it so much he became insane and senile, and lost all his memory of himself as a result.

Literature

Lord Voldemort (Harry Potter) created Horcruxes to attain immortality, but it resulted in the mutilation and isolation of his soul, forever trapped in limbo.

Witchers (The Witcher) gain superhuman physique due to their mutations, but the process is lethal to a large percentage of candidates and those who survive have their emotions permanently dulled.

Live Television/Movies

Bagi (Bagi, the Monster of Mighty Nature) was being exmperimented that give her enhanced physical attributes, human qualities, intelligence, and hypnosis, however the modifcations wore off with Bagi losing her intelligence, reverting her into savage beast.

After being given visions by Doyle, Cordelia Chase (Buffy the Vampire Slayer/Angel) began to suffer extensive brain damage from said visions and ultimately became part-demon to survive.

After being injected with the mixed blood of all three Charmed Ones, Dr. Curtis Williamson (Charmed) gained all of their active powers (Telekinesis, Molecular Immobilization, and Premonition),...

...but because mortals' bodies aren't meant to handle magic, his mind was warped by said powers, causing him to attack criminals and harvest their organs for transplants.

Chase Collins (The Covenant) ages every time he uses his power.

Castiel (Supernatural) became one of the most powerful beings in the universe by absorbing the souls of Purgatory...

...at the price of his vessel melting and warping of his mind.

After being branded with the Mark of Cain, Dean Winchester (Supernatural) was granted the ability to use the First Blade, but was driven to bouts of murderous rage that would kill him unless he killed something regularly...

...and when he did die, he was resurrected as a Knight of Hell class Demon.

The Equalizer/Hammurabi (Supernatural) wields the power to kill anything...

...at the cost of the same amount of damage being inflicted on the shooter.

Using his strength came at a cost that would age Griffin Grey (Arrowverse) a little bit every time. The more he exerted himself, the faster he aged, which was due to a combination of the protein in his DNA being ravaged by oxidants and his suffering from oxidative stress. This side effect had progressed so far that, while Griffin was chronologically 18, he physically progressed to his mid-30s after two years of living with his powers.

Video Games

ADAM (BioShock) grants its user superpowers, at the cost of slowly deteriorating the users body and mind, requiring them to use more.

Riddle Rosehearts (Disney: Twisted-Wonderland) in Overblot. Magic users produce a toxic substance called blot in their bodies with every use of magic and/or excessive mental trauma. This substance depletes with proper rest and care. Each person has a limit as to how much blot can be collected; reaching this limit causes the user to reach Overblot, which can be fatal.

Azura's (Fire Emblem Fates) pendant allows her to imbue her songs and dances with magical effects, but shortens her lifespan with each use.

After injecting himself with an experimental virus to gain superhuman abilities, Albert Wesker (Resident Evil) must regularly inject himself with a special serum to keep said virus in check.

After being experimented on by Sullivan, Zephyr (Resonance of Fate) developed superhuman strength and speed, but the nature of the experiments also unhinged his mind to the point he became a mass murderer.

By drinking the Rejuvenating Sediment of the Rejuvenating Waters, Lord Genichiro (Sekiro: Shadows Die Twice) gained incredible physical resilience and regeneration powers at the cost of gradually losing his humanity.

Toothpick (Sly Cooper: Thieves in Time) gets dizzy from spinning, making him vulnerable to an attack.

Metal Sonic's V. Maximum Overdrive Attack (Sonic the Hedgehog) is unstoppably powerful, but it overloads his circuits and slows him down after a short while, and could even destroy him as backlash.

When Shadow the Hedgehog (Sonic the Hedgehog) removes his Inhibitor Rings he taps fully into his Chaos Energy giving him a massive power boost at the risk of over-exerting himself.

Sonic gained new powers of cyber corruption (Sonic the hedgehog) after absorbing it to free his friends, but the more he absorbed it the more he was corrupted by it.

Vulture (Spider-Man PS4) developed terminal spinal cancer as a result of the power source of his high-tech artificial wings.

Infeliz H.png

Infeliz (Valkyrie Crusade) can accurately predict fortune and future, but each time she does so, she suffers misfortune.

Web Animation/Comics/Original

Due to acquiring a Talent as powerful as Ilios Phoenix Flame later in life, should Che Heart (Ordeal) use more than a little of it's true power will slightly damage him.

Anton King's (Ordeal) Talent allows him to use a certain percentage of Sun Wukong's power...

...however, using the talent at its full power can cause the death of the user of said talent.

SCP-427 - Lovecraftian Locket (SCP Foundation) is a locket capable of repairing cellular damage and purging any invading compounds or infections when it is exposed to biological material,...

...but will rapidly mutate organisms into shapeless masses of tissue (nicknamed "Flesh Beasts" by Foundation personnel) if it's used for extended periods.

Videos

ジョジョ- Joseph vs. Wamuu 『 Final』-2

I'll Use Everything - Hunter X Hunter

Rock lee vs gaara full Fight Eng (sub)-2

Batman vs Shredder - Batman vs Teenage Mutant Ninja Turtles-2

Sanji VS Rock Lee (One Piece VS Naruto) - DEATH BATTLE!

All Might VS Might Guy (My Hero Academia VS Naruto) - DEATH BATTLE!-2