Mine (Akame Ga Kill!) wielding the Roman Artillery: Pumpkin that fires spiritual energy bullets.
Coyote Starrk (Bleach) can fire powerful Cero from his dual pistols with deadly accuracy and potency.
Robert Accutrone (Bleach) fires bullets of condensed spiritual particles that ignites into blue flames with great skill.
Lille Barro (Bleach) the X-Axis is an expert marksman with a Reishi rifle.
Train (Black Cat) is a master marksman in accuracy and firing speed, especially with his Hades.
Toki (Code:Breaker) wields dual guns that are charged with magnetism to increase the force, and he can shoot with deadly accuracy.
Homer Simpson (The Simpsons) was so skilled with his gun that he was able to turn on the TV by shooting it at the right places.
Laguna Loire (Final Fantasy VIII) is skilled with guns.
Azureus (Azureus Rising) is skilled with guns.
Dante (Devil May Cry) is a master of the Gunslinger Style which allows him to maximize the versaility and accuracy of Firearms.
Shadow the Hedgehog (Sonic the Hedgehog), shows great skills in handling various firearms.
Zero (Kurohime) wielding his four guns at such speed and accuracy it appears he uses all four simultaneously.
Vash the Stampede (Trigun) is skilled at wielding various firearms, even dual wielding.
Revy (Black Lagoon) is so skilled using her dual modified Beretta M92 pistols that she goes by the moniker "Two Hands".
Jigen Daisuke (Lupin III) is an expert marksman. He can perform a 0.3-second quick-draw and has an accuracy that borders on superhuman; he can shoot skeet with a handgun, explode a missile before it hits by targeting the warhead, and deflect another bullet by shooting it in mid-flight.
Carmelita Fox (Sly Cooper) is incredibly adept at using her Shock Pistol.
Muggshot (Sly Cooper) wields numerous machine guns.
Toothpick (Sly Cooper) is an excellent shot, skilled with a variety of firearms that makes him a loose cannon
Whenever Aile (Mega Man ZX series) Double Megamerges to create Biometal Model ZX she acquires the shooting capabilities of X and the swordsmanship of Zero.
Officer Matthew "Matt" Cordell (Maniac Cop): "You have the right to remain silent...forever."
Panty (Panty and Stocking with Garterbelt) is able to form her panties into her spiritual gun, Backlace.
Much like her counterpart, Scanty (Panty and Stocking with Garterbelt) wields twin, golden revolvers the more powerful gun type than a common handgun.
Desperado (Valkyrie Crusade)
Isabel (Valkyrie Crusade)
Sharpshooter (Valkyrie Crusade)
...can use Shooters, like the Splattershot...
...Chargers, like the Splat Charger...
...and Splatlings, like the Heavy Splatling, all of which resemble guns, with proficiency.
...can use the Hero Shot...
...and the Hero Charger, both of which resemble guns, with proficiency.
Octolings (Splatoon) can use one weapon resembling a gun...
...the Octoshot, with proficiency.
April O'Neil (Teenage Mutant Ninja Turtles 2012 TV series)
The Fire Tank Pirates (One Piece) are highly skilled in wielding firearms such as revolvers and rifles
The Man With No Name (Dollars Trilogy) is truly a classic example of a skilled gunfighter.
Agent Whiskey (Kingsman) shows his remarkable gunmanship against a group of armed men.
Gill Bastar (WANTED!) was an extremely skilled gunman...
...outgunning and killing various bounty hunters with ease.
As an Eternal, Tien/Esser (Granblue Fantasy) is one of the most powerful and skilled gunfighters throughout the skies.
Nagumo Hajime (From Common Job to Strongest in the World) has outstanding marksmanship in dual wielding his technoimagical revolvers Donner and Schlag.
A gifted sharpshooter, Guido Mista's (JoJo's Bizarre Adventure Part 5 Golden Wind) uncanny precision with a revolver, supported by his ability to keep his cool even in the middle of a gunfight, makes him a particularly deadly individual and assassin.
Lance (Voltron Legendary Defender)