The Devil (Tenacious D and the Pick of Destiny) is skilled with a number of rocking tools, including singing, drums and electric guitar.
Combining his bass playing with his vegan powers, Todd Ingram (Scott Pilgrim vs. the World) can send out powerful shockwaves.
The Katayanagi Twins (Scott Pilgrim) uses their magical keyboard to summon twin dragons to attack the opposing band.
The Minstrel (Batman 60s series) was an electronic genius which was in fact a logical pursuit for someone who was also highly talented in music since both music and electronic energy are transmitted in waves.
The Robot Devil (Futurama) is able to masterfully play three bows on a solid-gold fiddle at once.
As a world-famous rockstar, Jagged Stone (Miraculous Ladybug) has a natural talent for music...
...a skill carried over in his akumatized persona Guitar Villain.
Having once been a rock and roll one-man band, Greg Universe (Steven Universe) is adept in the use of multiple instruments...
...a skill carried on in his son, Steven Universe.
The Devil (Devil Went Down to Georgia) makes bets with fiddlers on their skill, winning their souls should he win.
Johnny (Devil Went Down to Georgia) is so skilled on the violin that he beat the Devil in a fiddling contest, winning a fiddle of gold in the process.
Ninja Brian (Ninja Sex Party) is proficient in a number of instruments, and able to play the piano, pan-flute, maracas and a gong all at the same time.
Crash and the Boys' (Scott Pilgrim's Precious Little Life) are an incredibly talented band...
...Their opening number, I Am So Sad. I Am So Very Very Sad, was so fast it only lasts 0.4 seconds...
...and their last song, Last Song Kills Audience knocked out entire crowd into a 20-30 minute black-out sessions.
Combining his incredible bass playing with his vegan powers, Todd Ingram (Scott Pilgrim: The Infinite Sadness) can send out powerful shockwaves.
Musician (Valkyrie Crusade) is a so skilled musician that she is loved even by the god of music himself.
Bodi (Rock Dog) is a talented guitar play, even at a beginner's level, after being taught by Angus, he was able to save Snow Mountain and become co-guitarist of his band.
Angus Scattergood (Rock Dog) is a famous rock legend that specializes in rock music.
Fleetwood Yak (Rock Dog) was once a drummer in the city, however, when playing in Bodi's band, he retains his specialty.
Miku Izayoi (Date A Live) is a extremely talented singer.
Pumpkin Rapper (Mighty Morphin Power Rangers) would use his clever raps and rhymes to distract his opponents.
Sasha La Fleur (All Dogs Go To Heaven Series)
Brook (One Piece) is a virtuoso musician highly skilled in playing all kinds of instruments such as the violin...
The Chipmunks and The Chipettes (Alvin and the Chipmunks)
The Dazzlings/Sirens (My Little Pony: Friendship is Magic)
Coloratura (My Little Pony: Friendship is Magic)
Songbird Serenade (My Little Pony: Friendship is Magic)
Octavia Melody (My little pony: Friendship is Magic)
Mina Mongoose (Archie's Sonic the Hedgehog)
Alley Cats (The Aristocats)
Performing a guitar solo that was described by 2-D as "200 Demons Screaming in Arabic. Brilliant!", Noodle (Gorillaz) not only became The Gorillaz's lead guitarist...
...but also demonstrated her speculator musical talent as she wrote the band's Demon Days album...
...which also contains DARE, the first song she did almost everything, including instrumentals and singing....
...she also incredibly played the melodica while performing Broken.
Alley Cats (The Aristocats)