Users, either innately or through training, are masters of handling and wielding weapons, any implement or device that can be used with the intent to inflict damage or harm, beyond that of the peak members of the species. This means users are skilled in wielding various forms of weapons, from swords to hammers to chains to sniper rifles, being able to beat anyone wielding similar forms of weapons instantly and effortlessly.
Users can perfectly and without a single flaw or mistake use any and every type of weapon there is, was and will ever be whenever they want with 0 zero effort. Being proficient in any weapon comes with a plethora of various abilities as well, like overall better precision, accuracy and combat capabilities.
Despite being an infant, Stewie Griffin (Family Guy) displays perfect mastery of any type of weapon.
In addition to his sword, Jack (Samurai Jack) is able to use any weapon he finds.
Trained from a young age to kill, Ashi (Samurai Jack) knows how to handle most weaponry.
Despite a lack of formal training, Bean (Disenchantment) is remarkably skilled with bladed weaponry.
As a monster slayer, Vampirella (Vampirella) has had plenty of time to become proficient with multiple weapons, including swords...
...and wooden stakes.
Sticks the Badger (Sonic Boom)
Frank Castle/The Punisher (Marvel Comics)
Spawn (Image Comics)
Dark Turtles (Teenage Mutant Ninja Turtles 2003 TV series)
Maxwell "Max" Tennyson (Ben 10 Franchise)
Danny Fenton/Phantom (Danny Phantom) is able to use any ghostly artifact or his parent's inventions as weapons whether it is pole weapons...
… or even anti-ghost gun.
Oliver Queen/Green Arrow (Arrowverse/DC Comics)
Jonathan Kent (Superman and Lois/Arrowverse) has trained on how to use firearms from John Henry Irons. Later also being guided by Sam Lane on how to fire them. After Jon found Irons' weapons, he hid them in the barn and used one to shoot two Kryptonians…
…temporarily tried to use one of Sam Lane's pistols that was loaded with Kryptonite against Tal-Rho…
…then was handed a modified version of Killgrave's sonic weapon by John Henry Irons to protect Lois Lane while she was inside Jordan's Eradicated mind. He used it to fight Zeta-Rho who possessed Jordan's body.
Stick (Marvel Cinematic Universe) is a extraordinary master of the sword and archery.
Anakin Skywalker's (Star Wars) style featured elements of many masters, making him outstandingly talented, even at a very young age…
…and after becoming Darth Vader he developed a refined version of Djem So that continued to include Ataru and Soresu elements but added Makashi and Juyo to the mix.
An adept in using a variety of weapons, Kyle Katarn's (Star Wars Legends) training from Imperial Academy gave him great skill in using Imperial weapons which he combines with his natural intuition has allowed him to use every weapon he came across in his travels.
Gabriel Van Helsing (Van Helsing)
From fighting villains before The Annihilator took her powers, Skylar Storm (Mighty Med) is able to use her anything as a weapon or even use weapons without no experience of using it like she used Captain Atomic’s Atomic Yo-Yo of Victory with no difficulty.
Beetleborgs (Saban's Big Bad Beetleborgs/Beetleborgs Metallix)
Freddy Krueger's Glove (A Nightmare on Elm Street)