"Our city has seen incredible...impossible things. Metahumans, men and women with extraordinary abilities. The ability to soar above buildings, to run faster than the speed of light. Unfortunately, most of these Metahumans have chosen the wrong path with these powers, a dark path."
― Harrison Wells explaining about Metahumans. (Arrowverse)
Advanced/Augmented/Enhanced/Modified Human Physiology
Evolved Humans/Evos (Heroes)
High Humans (The New Gate)
Homo Sapiens Superior Physiology (Marvel Comics)
Homo Superius Physiology
Superpowered Human Physiology
Superior Human Physiology
User is a human being that has developed powers and abilities from a variety of causes, such as evolution, genetic experiments, enchantment, having powers bestowed upon them by other beings or sources, through birth, and training in order to obtain said powers. Also, thanks to the human side of their heritage (if the powers are genetically-based), they are able to use these abilities without becoming a monster (i.e. keeping their human physique, sanity, and humanity without it being altered from possible instability).
Homo Superiors can also be divided into two categories:
Metahumans of this category gain their powers via evolution, birth, genetic engineering, or exposed to radiation or biohazardous substances, like mutagens, or any other methods that involves genetic experimentation in that regard.
In one way or another, certain homo superiors that are of this classification will may have minor physical changes without their humanity being fully or almost slipped away, like their irises changing to any color like a fiery shade of red, yellow, purple, etc, retractable claws or spikes, fangs or sharp teeth, color of the skin being changed, among others. In fact, these kinds of superhumans will be able to possess powers without their physiology being altered and lose their humanity as a result.
Unlike rational-based homo superiors, this category of metahumans wouldn't have to be able to suffer mutations and instability of their deoxyribonucleic acid, which can be caused in certain ways. Unlike the rational based, these kinds of superhumans are more likely to maintain their humanity because they don't share the same genetic unpredictably that rational-based superhuman are more likely to have.
Unless they have specific immunities/resistances, users have the same weaknesses as regular Humans.
Mystical-based abilities may based on curses and cause involuntary loss of control causing dangerous damage to themselves and those around them.
Genetic-based abilities may become unstable and cause secondary/unwanted mutations, and at worst, could become a Monstrous Mutant if not kept under treatment.
Metahumans can also technically exist in real life due to modification existing in real life also. In further context, Humans that happen to have been injected with anti-bodies to gain resistance against diseases for example, can be classified as Superhumans. In China, a scientist named He Jiankui had decided to test the waters in modifying Human embryos to have the power to withstand HIV, which is well known to be a virus. Even if they where grown up into Humans, they will likely still have the modifications intact, which can classify them as Metahumans.
Neohumans (Action Man)
Benders (Avatar series)
Mutant Humans (Ben 10 series)
Osmosians (Ben 10 series)
Philip J. Fry I (Futurama)
Metahumans (DC Animated Universe)
Metahumans (Dexter's Laboratory)
Normal Human E.V.O.s (Generator Rex)
Trina Riffin (Grojband)
Team Go (Kim Possible)
Elemental Masters (Lego Ninjago: Masters of Spinjitzu); via unlocking True Potential
The Rainbooms (My Little Pony: Equestria Girls Series)
K.O. (OK K.O.! Let's Be Heroes)
The Powerpuff Girls (The Powerpuff Girls)
Jack (Samurai Jack)
George Washington (DC Comics/Teen Titans Go!)
Richard John Grayson/Robin (DC Comics/Teen Titans Go!); temporarily
Alex Mann/Action Man (Action Man) is a Metahuman who uses the AMP Factor to predict eventual outcomes, and alter them via choices of obstacles that he must use to prevent the happenings before they occur.
After being struck by lightning Templeton Storm/Tempest (Action Man) has gained powers based on meteorological phenomena.
Wolfgang Greenholtz/Professor Gangrene (Action Man) is a scientist whose experiments accidentally turned him into a Superhuman.
Victor Fries/Mr. Freeze (DC Animated Universe) became a Metahuman after an accident soaked his body in a freezing solution, rendering him unable to survive outside of a sub-zero environment, but also slowing his aging to the point where he is essentially immortal.
Leslie Willis/Livewire (DC Comics/Batman and Beyond) became a Metahuman after she was struck by a lightning bolt, causing her to become a Human of pure electrical energy.
Ever since the magic had spilled out from Equestria into the Human world, The Rainbooms (My Little Pony: Equestria Girls Series) had been given various powers as a result.
After being dosed with the mutagenic chemical known as Quantum Vapor, Virgil Ovid Hawkins/Static (DC Comics/Static Shock) became a Metahuman with the ability to manipulate and control electromagnetic phenomena.
The Super-Inhumans (Marvel Comics) are a subspecies of Inhumans, and are considered to be much more stronger than them whenever the Kree have been modifying the Inhumans even further.
James "Logan" Howlett/Wolverine (Marvel Comics)
Scott Summers/Cyclops' (Marvel Comics) optic blasts manifest for the first time.
Warren Worthington III/Angel (Marvel Comics) manifesting his wings during puberty.
After he was affected by the chemical known as Diox-3, it directly modifies Lonnie Thompson Lincoln/Tombstone (Marvel Comics) into a Human Mutate, possessing powers such as Supernatural Body and Oxygen Independence.
Luna Maximoff (Marvel Comics) is a Mutant/Inhuman hybrid.
Reed Richards/Mister Fantastic (Marvel Comics) gained his powers from cosmic radiation, rather than being born with those powers like a mutant due to lacking the X-Gene which mutants possess.
Peter Benjamin Parker/Spider-Man (Marvel Comics) is a mutate with powers of a spider due to being bitten by a radioactive spider.
After being genetically imprinted with the DNA of a spider, Miguel O’Hara/Spider-Man 2099 (Marvel Comics) gain a variety of superhuman attributes of a spider, along with many traits and abilities of one.
Miles Morales/Spider-Man (Marvel Comics) is a spider-based mutate, with a different power set compared to Peter Parker.
Matthew "Matt" Michael Murdock/Daredevil (Marvel Comics) is a mutate who became blind but his remaining senses were amplified to superhuman levels as the result of exposure to a radioactive isotope.
Various Characters (To Aru Majutsu no Index) have either science-based or magical influenced powers.
Quirk-Users (My Hero Academia) are humans - and occasionally animals - who are born with a specific superpower or "quirk". Within the entire earth, quirk-users make up over 80% of the world's population.
The Vinsmoke siblings (One Piece) are modified humans.
Ryūhō Tairen and Kazuma (s-CRY-ed) are known as Alters, individuals who are able to shape and reconstruct matter through mental focus and willpower.
Kai Kudō and his friends (E's Otherwise) are as Espers born with psychic powers.
SCP-040 - Evolution's Child (SCP Foundation) is a Metahuman with the power to manipulate the biology of virtually all life, allowing her to induce mutations as well as manipulate said mutations.
SCP-049 - Plague Doctor (SCP Foundation) is a Superhuman with the power to kill via touch and reanimate the bodies of the people he has killed.
SCP-053 - Young Girl (SCP Foundation) can induce intense hatred and uncontrollable anger towards her when individuals have managed to touch her, make eye contact, or even remain around the child for longer than exactly ten minutes. She’s also capable of regenerating from physical injuries.
SCP-353 - “Vector” (SCP Foundation) is a disease manipulating Metahuman, and as a subpower to her signature ability, she can also accelerate diseases within those she infected, killing them much more quickly in the process.
SCP-590 - He Feels Your Pain (SCP Foundation) can transfer another’s injuries onto himself, which earns his SCP title.
SCP-1440 - The Old Man from Nowhere (SCP Foundation) became a Metahuman when he came into contact with the Brothers Death, being cursed to cause fights between individuals, and an Unnatural Presence, which causes various disasters that can potentially harm humanity or other objects he comes across.
Despite having a deformed face at birth, Psycho Mantis (Metal Gear series) possessed psychic powers. Moreover, his psionic abilities had eventually waxed to the point of breaking and interacting with the fourth wall.
Lena Oxton/Tracer (Overwatch) became a Superhuman through an accident regarding the aircraft she's using with a teleportation matrix malfunctioning, giving her abilities associated with time, like Temporal Rewind, Temporal Healing, and Time Acceleration.
In efforts to make Gabriel Reyes/Reaper (Overwatch) more powerful, TALON had experimented on him to turn him into a Metahuman with powers based on darkness, including Umbrageous Teleportation, and Shadow Generation.
All thanks to the Prototype Virus that had been injected into him, it modified Albert Wesker (Resident Evil series) into a Metahuman, possessing Supernatural Body, and he possesses Enhanced Regeneration.
Before Alexia Ashford (Resident Evil series) had mutated into a monster due to the T-Veronica Virus, the earlier stage is that the virus first modified her, thus giving her powers such as Tentacle Extension, and Flammable Blood.
Ever since the Golgotha Virus had modified her in conjuction with the DEVIL vaccine, Sherry Birkin (Resident Evil series) was turned into a Superhuman with Enhanced Regeneration.
Having been merged with NETRICSA, which is basically an AI designed for virtually any combat situation and obstacles, Sam "Serious" Stone (Serious Sam series) can beat back a horde of enemies, and he also managed to defeat the wind God known as Kukulkán with certain normal weaponry.