The user is immune to any/all forms of physical damage/harm, unable to feel physical pain, is immune to bleeding or loss of limb. Death due to old age (as opposed to preemptive death) is seemingly the only cause of death to the user.
Broly's (Dragon Ball Z: Broly - Second Coming) Legendary Super Saiyan form, reinforces his body with tremendous ki to the point where he is completely unaffected by Son Gohan' SSJ powered punch to his face.
The Third Raikage (Naruto) is virtually immune to any attacks grants to his Lightning Chakra Armor.
Kakuzu (Naruto), using Earth Spear, is invulnerable to all physical damage, aside from Lightning Release techniques.
As a Rubber Human, Monkey D. Luffy (One Piece) is invulnerable to conventional gunfire and physical attacks.
Logia Devil Fruit Eaters (One Piece), like Portgas D. Ace, are all practically invulnerable due to their individual elemental Devil Fruit powers.
Because of the powers of the Dice-Dice no Mi, Daz Bones (One Piece) is immune to bullets, slashing and physical attacks.
Masters of Six Powers/Rokushiki (One Piece) can use the Tekkai/Iron Body technique to make their bodies invulnerabilty and indestructible.
While in his Monster Point form, Tony Tony Chopper (One Piece) possesses a body so hardened that all attacks bounce off of his without him even recoiling.
Thanks to the power of the Diamond Diamond no Mi, Jozu (One Piece) can become diamond to block any and all attacks.
Besides being one of the most powerful and feared Four Emporers/Yonko in the world, Kaido (One Piece) is also known for his indestructible body. Demonstrating during one of his many infamous suicide attempts when he jump off a sky island…
…and came out completely unscathed despite landing face first.
Charlotte Linlin/Big Mom (One Piece) has a near invulnerable body, being able to withstand cannon blasts and thunderbolts as though nothing, except when she is emotionally vulnerable or when starved from extended hunger pangs.
Born with steel-like exoskeletons, the Vinsmoke Siblings (One Piece) are all incredibly indestructible, each of them immune to conventional firearms and blades.
The Silver Surfer (Marvel Comics) takes a blow to the face from She-Hulk and remains unfazed.
In his Steel form, Colossus (Marvel Comics) is virtually invulnerable.
After absorbing Ms.Marvel's Kree based super powers, Rogue (Marvel Comics) gained her incredible invulnerability.
Luke Cage's (Marvel Comics) unbreakable skin allows him to take an explosion to the face...
...and shrug off a laser bolt.
The Sentry (Marvel Comics)
Gladiator (Marvel Comics)
Tombstone (Marvel Comics)
Kimura (Marvel Comics) uses density control to compact her molecules increasing Mass (weight) while keeping intact her Volume (size by length, width, and dept) in effect increasing her Density (damage durability) making her virtually indestructible and impervious.
America Chavez (Marvel Comics)
Emma Frost (Marvel Comics)
It is impossible to damage Brit (Image Comic) through any means, including magma, falling buildings, and strong attacks.
Invincible (Image Comics) taking all of Dark Wing's exoskeleton-powered punches.
Allen the Alien (Image Comics) surviving all his death sentences while in a Viltrumite Prison.
The Annihilator (Justice League: Unlimited) is invulnerable to every attack due to its magical armor, making it practically invincible.
Juggernaut (X-Men: Evolution)
Aku (Samurai Jack) can only be harmed by Jack's mystical samurai sword.
Grandfather (Codename: Kids Next Door) was invulnerable to all physical damage, as even having a giant moon base worth 39 gazillion tons of red hot metal and duct tape dropping on him did not do any harm.
Shendu (Jackie Chan Adventures) can only be harmed by magical weapons.
King Koopa's henchmen (The Super Mario Bros. Super Show!) all wearing Unzappable Hats, which render the wearer invulnerable.
The Oni Mask of Hatred (Lego Ninjago: Masters of Spinjitzu) turns the user's skin into invulnerable magma armor.
Harumi (Lego Ninjago: Masters of Spinjitzu) wearing the Oni Mask of Hatred.
Ultimate Kevin (Ben 10: Ultimate Alien) possesses Humungousar, Ultimate Humungosaur, Four Arms and Ultimate Aggeregor's durability.
Kevin 11 (Ben 10) possesses Diamondhead's and Four Arms' durability.