The user is constantly unlucky causing to go through a series (unless temporary) their whole life such as diseases, susceptibility to permanent injuries, bankruptcy, etc.
People even the user's closest friend and family may react or treat user differently or negatively, maybe picking a fight with them for no reason, doing terrible things to them, or just making their life more miserable than it already is.
Alex King (Worst Year of My Life Again); via time resetting
Ataru Moroboshi (Urusei Yatsura)
Jackson Wells (Zoophobia)
Knuckles the Echidna (Sonic Boom; formerly)
Miles "Tails" Prower (Sonic Boom)
Annie (Generator Rex)
It is said any human who uses a Death Note (Death Note) will have nothing but misfortune...
...Light Yagami, a bright young man who lost his sister's mental health, his father's life,...
...and ultimately his own life...
...Misa Amane, a famous model and actress, but after using the Death Note she was briefly confined and when she lost her memories after relinquishing the notebook twice she ended up losing permanently that also lead to her suicide after hearing Light's death...
...Kyosuke Higuchi, a successful (albeit only with the Death Note) businessman who fell apart into a desperate car chase and then assassinated by Light...
...even though Kiyomi Takada, a famous NHN news reporter, was using pages from the Death Note, she ended up being kidnapped by Mello and later assassinated by Light to avoid loose ends after she killed her captor...
...and Teru Mikami, a successful attorney who was driven increasingly insane that ultimately led him to end his own life in prison.
Barney Stinson (How I Met Your Mother)
Elijah Price (Unbreakable) theorizes that if he is frail at one extreme, then perhaps there is someone strong at the opposite extreme (which pertains to David Dunn).
Tim (The Life & Times of Tim) can never catch a break.
No matter what hair brain scheme the gang of Philadelphia (It's Always Sunny in Philadelphia) comes up with it will always backfire.
The Charmed Ones (Charmed) Obtained bad luck temporarily until they learned gradually counteract it
Jake Hardin (Just My Luck) is followed by bad luck wherever he goes.
Touma Kamijou (To Aru Majutsu No Index) possesses horrible luck as a side effect of his Imagine Breaker.
Anti-Fairies (The Fairly OddParents)
Donald Duck (Disney) has practically supernatural levels of misfortune.
Ataru Moroboshi (Urusei Yatsura) was born on Friday the 13th, in the middle of an earthquake, on Butsumetsu (the day Buddha died), considered the unluckiest day in the Japanese calendar.
Peter Parker/Spider-Man (Marvel Comics) possesses his family's infamous Parker Luck, where small victories are overshadowed by crushing demoralizing setbacks.
Milo Murphy (Milo Murphy's Law)
Jack (ZooPhobia) is cursed with perpetual bad luck and immortality.