The Alien (Gleipnir) has absolutely no understanding of human morality, and cannot even comprehend the fact that he has personally ruined the lives of tons of people or that his actions have lead to the deaths of those that weren't involved with him or the Coin Game.
The Childlike Empress (The Neverending Story)
As an Incubator, Kyubey (Puella Magi Madoka) has no moral standings or emotions to hinder him. As his reasoning is that preventing the Heat Death of the Universe is the only thing that truly matters and thus doesn't care if the lives he ruins are good or evil.
Glossaryck (Star vs. the Forces of Evil) has no side in regards of right/good and wrong/evil.
The Sapphire Dragon (Xiaolin Showdown) has no understanding of right or wrong or good or evil, its only purpose is to turn everyone and everything, good, evil or indifferent; into a sapphire statue.
Balancer (Valkyrie Crusade) being the weigher/balancer of all things, is completely amoral.