Users possess immense combat skills, both offensive and defensive, that far surpass other beings of their verse. Their skills may be highly innate superhuman, honed or both.
This encompasses speed, strength, precision, reflexes, technique, analysis, control, adaptation, and all aspects of practical fighting. Depending on the users, they may be specialized in specific types of weaponry (melee, ranged, natural, etc.), and invariably wield them with surreal efficiency, or possess incredible unarmed combat skill or have superhuman proficiency to utilize magic or their superpowers in combat and can perform inconceivable supernatural feats. Most observers are simply incapable to understand what's happening, with only a user being able to gauge the skill of another.
Urashiki Ōtsutsuki (Boruto: Naruto Next Generations)
Victor (Boruto: Naruto Next Generations)
Deepa ("Boruto: Naruto Next Generations")
Various Characters (One-Punch Man)
Various Characters (Record of Ragnarok)
Cid Kagenou (Minoru Kagenou) (The Eminence in Shadow)
Honoka (The Third: Girl with the Blue Eye)
Various Characters (Yongbi the Invincible)
Various Characters (Yu Yu Hakusho)
Clark Kent/Kal-El/Superman (DC Comics)
Diana/Wonder Woman (DC Comics)
The Drowned (DC Comics)
Dark Danny/Dan Phantom (Danny Phantom)
Olympia (Hero Heights)
Supreme (Image Comics)
Viltrumites (Image Comics)
Savage Dragon (Image Comics)
Thor Odinson (Marvel Comics)
Hercules (Marvel Comics)
Gorgon/Tomi Shishido (Marvel Comics)
Debbie Devizo (Supermansion)
Practitioners of the Hercules Method (The Strange Talent of Luther Strode)
Mr. Majestic (Wildstorm/DC Comics)
Miraculous wielders (Miraculous: Tales of Ladybug & Cat Noir)
Optimus Prime (Transformers)
Asura (Asura's Wrath)
Raidou (Dead or Alive)
Sam "Serious" Stone (Serious Sam series)
Death (Darksiders 2)
Jakob/Cult Leader (New Blood Interactive's DUSK)
Yang (Final Fantasy IV)
Sephiroth (Final Fantasy VII)
Kratos (God of War)
Baldur (God of War)
Raiden (Mortal Kombat)
Shao Kahn (Mortal Kombat)
Shinnok (Mortal Kombat)
Ryu Hayabusa (Ninja Gaiden)
Akuma (Street Fighter)
Gouken (Street Fighter)
Ryu (Street Fighter)
Jinpachi Mishima (Tekken)
Heihachi Mishima (Tekken)
Kazuya Mishima (Tekken)
Lars Alexandersson (Tekken)
Jin Kazama (Tekken)
Scathach (Valkyrie Crusade)
Sonic the Hedgehog (Sonic the Hedgehog)
Knuckles the Echidna (Sonic the Hedgehog)
Shadow the Hedgehog (Sonic the Hedgehog)
Hela (Marvel Cinematic Universe)
Thanos (Marvel Cinematic Universe)
Gorm (The New Legends Of Monkey)
The Monkey King (The New Legends Of Monkey)
Eric (Ryu Han-Bin) (Survival Story of a Sword King in a Fantasy World)
Various Characters (unOrdinary)
Skull Knight (Berserk)
Nosferatu Zodd (Berserk)
Yoruichi Shihoin (Bleach) is one of the greatest martial art masters in Soul Society, able to take down an entire squadron of highly skilled Hakuda experts in seconds.
Claymores (Claymore) possess combat abilities far above human limits due to the fusion and grafting of Yoma flesh to their bodies...
...Teresa of the Faint Smile was said to be the strongest Claymore to ever have existed. As such she could effortlessly detect and kill Youma posing as humans...
....to the point where even the strongest Awakened Beings called her a monster.
Priscilla's (Claymore) combat skills increased tremendously during her awakening, taking down an above-abyssal awakened without sustaining any damage.
Alicia (Claymore) is one of the most skilled warriors, both in human and awakened form, thanks to her enormous natural abilities and extreme training.
Kurumi (Date A Live) as an S-Class Spirit can destroy an army of Bandersnatch robots by herself.
Son Goku (Dragon Ball Z)
Frieza (Dragon Ball Z)
Nappa (Dragon Ball Z)
Raditz (Dragon Ball Z)
Android 18 (Dragon Ball Z)
Android 17 (Dragon Ball Z)
A Devil who is also a martial art master, Sairaorg Bael (Highschool DxD) is able to defeat High-Class Devils using pure might and skill.
Issei Hyodou (Highschool DxD)
Vali Lucifer (Highschool DxD)
Hashirama Senju (Naruto), Konoha's First Hokage, was so overwhelmingly powerful and skilled that he was titled the God of Shinobi/Ninjas.
A (Naruto) was able to single-handedly fight off 10,000 Iwagakure shinobi for three days and three nights nonstop before finally succumbing to death.
Kokuyō (Boruto: Naruto Next Generations) is an artificial human who possesses superhuman combat skills.
Bang/Silverfang (One-Punch Man) is able to use the Fist of Flowing Water, Crushing Rock technique in order to defeat opponents several times bigger and/or stronger than himself. Charanko, Garou, Sour Face & Orochi are also known users of this technique
Metal Bat (One-Punch Man) is able to get more "Pumped Up" according to how much damage he has taken which drastically enhances his Physical Capabilities to Supernatural heights
Scathach (Valkyrie Crusade) is the goddess of melee and magic.
Yang's (Final Fantasy IV) combat skills are so highly trained that he is capable of fighting and defending against an army of soldiers and monsters all by himself.
Aside from his immense power, Raiden (Mortal Kombat) has an encyclopedic knowledge of over 700 martial arts fighting styles, which no human, mortal, or any other God has.
Shao Kahn's (Mortal Kombat) fighting prowess, as well as his necromancy, astral manipulation abilities, and his immense godly strength are so high, it enables him to fight on equal footing with Raiden and is why Shao Kahn is the most dreaded emperor of the realms.
Kratos' (God of War) immense strength and combat skills allow him to defeat entire armies of monsters, the entire Greek pantheon, and the nine Valkyries.
Raidou (Dead or Alive) is an extremely dangerous ninja due to his immense power and supreme fighting skills.
At the time of fighting the cult and as well as its past leader, Jakob/Cult Leader (New Blood Interactive's DUSK) had fought them with absolutely no help whatsoever, and this had caught Nyarlathotep's attention into being interested in his potential, and decided to give him the position as his own henchman. But as Dusk Dude eventually came to their fruition in an attempt to defeat them and ending their cosmic rampage once and for all, he actually managed to put an end to Jakob due to how more superior he is in comparison to his combat expertise.
Yaiba (Ninja Gaiden) is called the Demon Ninja due to his immense power and fighting skills which are nearly on par with Ryu.
Ryu Hayabusa (Ninja Gaiden) as most powerful ninja ever existed, is capable of slaying the most powerful supernatural beings such as Greater Fiends and Archfiends.
Heihachi Mishima (Tekken) is a powerful martial art master able to fight his grandson, Kazuya in his Devil form on an equal level.
Even though Sam "Serious" Stone (Serious Sam series) is the pinnacle of heroism, sheer badassery, and with NETRICSA being in sync with him, he can eradicate entire armies of Mental's monsters, managed to defeat Ugh-Zan III on his own, and he fought on equal footing with Kukulkan the Wind God.