Nomura Fudo (Busou Shoujo Machiavellianism) focuses his physical strength in a single hand.
Via the technological devices on his palms, Android 19 (Dragon Ball Z) can absorb energy blasts and ki.
Bacchus Groh (Fairy Tail) uses his Palm Magic to focus his Magic Power in the palm of his hands, significantly boosts the strength of the attacks he performs with the hands.
After painting a magic symbol from the Scroll of Hung Chao, the Old Monk (Jackie Chan Adventures) became able to project powerful chi energy blasts from his hands, levitate, and animate inanimate objects.
Pit (Kid Icarus) using a Palm weapon, allowing him to harness his own life energy shoot it as projectile.
Julian Keller/Hellion (Marvel Comics) channeling his telekinesis through his palms.
Zero (Mega Man Zero series) can use his Zero Knuckle weapon to rip off enemy parts and use them.
Lie Ren (RWBY) uses his Aura to enhance his palm to destroy a King Taijitu's head.
With the power of the Paw Paw Fruit/Nikyu Nikyu no Mi, Bartholomew Kuma's (One Piece) hands became engraved with paw pads...
...that allow him to repel whatever he touches.
Sengoku (One Piece) launching a Golden Shockwave which can cause heavy damage on a large group of enemies.
Charlotte Linlin/Big Mom (One Piece) performs a palm strike enhanced by Zeus's lightning.