The user requires artificial/external means to regulate and stabilize their otherwise uncontrollable powers. Without these regulators, the user's powers could be a danger to themselves or those around them. Said regulators typically take the form of a technological device.
In some cases, the user performs certain tasks or techniques, such as meditation, to keep their powers under control.
Negative Man (DC Comics) must constantly wrap himself head-to-toe in special bandages to keep his radiation from harming others.
Raven (Teen Titans) must meditate daily to keep her emotions and powers in check.
Samantha Argent of Project HK (Hunter Killer) gives off uncontrollable bio-energy emissions and can only keep her powers grounded through specially designed discharge units which double as weaponized conduits.
Blackagar Boltagon/Black Bolt (Marvel Comics) has gone through rigorous training to control his destructive voice, and the antenna on his head helps to channel it.
Scott Summers/Cyclops (Marvel Comics)
Alex Summers/Havok (Marvel Comics) needs to wear a special suit to keep his powers in check to avoid accidentally hurting someone.
Jennifer Takeda/Hazmat (Marvel Comics) needs to wear a containment suit whenever she is outside of a controlled environment.
Jamie Madrox/Multiple Man (Marvel Comics) requires a special suit to keep himself from multiplying from impacts.
Ann Marie LeBeau/Rogue (Marvel Comics) needs to keep her skin covered to keep her powers from harming others.
Surge (Marvel Comics) must wear specifically-designed gauntlets at all times to regulate her electricity.