Koshirō Chikuma (Basilisk) wields dual sickles (kama) with great skills, and even throw them with perfect accuracy as boomerangs.
Undertaker (Black Butler) is able to use his Death Scythe with great skill even though he is far sighted.
Ragna the Bloodedge (BlazBlue) has the Blood-Scythe turned from sword to scythe as its awakened form.
Nnoitra Gilga (Bleach) wields six scythes upon his Resurrección, Santa Teresa, which he wields destructively and skillfully.
Shūhei Hisagi (Bleach) wielding his Kazeshini, a pair of dual-bladed kusarigama, with tremendous skills and dexterity.
Dark Rukia (Bleach) wielding her scythe that can erase memories of those it cleaves, and create energy rifts.
Rui Hachiōji (Code: Breaker) wielding a shadow scythe with deadly skills.
Trish (Devil May Cry) awakened the Sword of Sparda's dormant state that it turned into a scythe.
Zorin Blitz (Hellsing) wielding her scythe with great skill, easily cleaving a man in two and even throwing it with deadly accuracy.
Marluxia (Kingdom Hearts), also known as "The Graceful Assassin", wields the power of "flower, conjuring it through his scythe.
Rinne Rokudo (Kyōkai no Rinne) wields his Shinigami scythe with great proficiency when fighting demons or purifying evil spirts.
The young Shinigami Ageha (Kyōkai no Rinne) wields her scythe to battle and purify evil spirits.
Hidan (Naruto) wielding his Triple-Bladed Scythe with tremendous agility and dexterity, thanks to the attached cable.
Doc Q (One Piece) wielding a giant double sided scythe with great proficiency despite his ailing health.
Scyther (Pokemon) lives up to its name, using its scythe hand appendages with deadly sharpness and speed, and even fire off Razor Wind.
Alexander Nikolaevich Hell (The Qwaser of Stigmata) wields his signature iron scythe with tremendously deadly skills.
Yuki Cross (Vampire Knight) wielding the Artemis scythe with enough proficiency to kill a powerful pure-blood vampire.
Guardian Deathscythe (Yu-Gi-Oh!) wields a gigantic Reaper Scythe that is empowered by her fallen comrades, making her Forbidden Requiem technique a very deadly force to be reckoned with.
Moloch (Valkyrie Crusade)
Gehrman (Bloodborne) was known for his trick weapon "Burial Blade", a blade that can become a scythe.
Crossbreed Priscilla (Dark Souls)
Sister Friede (Dark Souls III)
Peta (Marchen Awakens Romance) can bring out a scythe Weapon ÄRM called Sickle Death
One of the Sisters (Kubo and the Two Strings) is adept at the use of a chain-scythe/claw weapon.
In his final form, Orb (Marchen Awakens Romance) acquires an enormous scythe which he is shown to wield with great speed.
Ryu Haybusa (Ninja Gaiden) wielding the Eclipse Scythe with tremendous skill and dexterity.
Sailor Saturn (Sailor Moon) in her role as Goddess of Death and Deity of Destruction weilds the The Silence Glaive ( referred to as the scythe of the Goddess of Death)
Rita Rossweisse (Honkai Impact 3rd)
Seele Vollerei (Honkai Impact 3rd)
Pitch Black/The Bogeyman (Rise of the Guardians) taking on the Guardians with his black dreamsand scythe.
Erigor (Fairy Tail) is a masterful scytche user, earning him the nickname "Grim Reaper."
Kama (Fairy Tail) is a profficent user of Scythe Proficiency.
Each generation of Shadowmen (Valiant Entertainment Comics) has wielded the Shadow Scythe, a powerful mystic weapon capable of truly killing the undead and residents of the Deadside.
Tobio Ikuse (Highschool DxD) mastery of the scythe is far deadlier than the strongest Grim Reapers.
Killer (One Piece) hailed as the Soldier of Massacre for his formidable skills with Sickles.
EraseMan.EXE (Mega Man Battle Network 6)
CFW Magic (Hyperdimension Neptunia mk2)
Kirika (Senki Zesshou Symphogear) wielding her Armed Gear, Igalima.
Deed (Superior Defender Gundam Force)
Whirlweasel (Yo-Kai Watch)
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Grim Creeper (Skylanders)