Vash (Trigun) was able to focus all of his senses on an injury to protect himself from Dominique's hypnotic power.
Ikki Kurogane (Rakudai Kishi no Cavalry) has full mastery over his body including his five senses and controlling the details of what he can see.
By focusing his senses, Wolf Link (The Legend of Zelda: Twilight Princess) can track scents he finds...
...and see what is usually invisible to the naked eye, such as ghosts.
By concentrating hard enough and focusing his 'antennae', Ryo Shimazaki (Mob Psycho 100) can use his Super Sensory Zone - Mind's Eye to sharpen his extrasensory perception until all he can "see" are the objects of his focus, in this case other esper's auras.
By ignoring all of his other senses, Peter Parker/Spider-Man (Marvel Comics) can focus his Spider-Sense to locate specific targets.
Spider-Man's Suit (Marvel Cinematic Universe) is designed with special lenses that help him filter and focus his senses.
Jack (Samurai Jack) has trained to focus and hone his senses, allowing him to fight and navigate while blindfolded.
Kara Zor-El (Smallville/DC Comics) focusing her hearing to track her ship's beacon.
Jim Ellison (The Sentinel)
Shinchi Izumi (Parasyte) can focus on his senses ever since merging with Migi's cells.
As a Synesthete Alpha, Rachel Pirzad (Alphas) can focus any of her senses at will.