Eclipse the Darkling (Archie's Sonic the Hedgehog) is a Black Arms super-soldier created to be his species' answer to Shadow the Hedgehog.
The Ultimate Alien Forms (Ben 10 Ultimate Alien) are super soldier counterparts of alien species who had been genetically altered by the Ultimatrix through survival of the fittest simulation, evolving them for combat.
The Corpse Corps (Blood+) are artificial chiropterans created for the sole purpose as military weapons.
Adam (Buffy the Vampire Slayer) is the end result of the 314 Project, a military super-soldier program meant to combine the advancement of technology with the intelligence and adaptability of humans and the superior strength and emotional detachment of demons.
Max Guevara (Dark Angel) is a member of the X5 series of super-soldiers.
Buddy Blank, the One Man Army Corps (DC Comics)
Kasumi Alpha (Dead or Alive) is a product of DOATEC's Project Alpha., a super-soldier project centered around clones of the kunoichi Kasumi.
Alpha-152 (Dead or Alive) is the penultimate result of Project Alpha.
Phase 4 (Dead or Alive) is the prototype of Project Alpha's final result.
River Tam (Firefly) was partially transformed into a psychic super-soldier by the Alliance.
A test subject for a classified Japanese super soldier project during her childhood, Noodle (Gorillaz), along with 22 other children, were trained with the sole purpose of fighting as soldiers for the Japanese military and government.
Cy-Gor (Image Comics) is the end result of Project SIM: a half-man, half-gorilla monster enhanced with cybernetics.
Riptor (Killer Instinct) is a product of UltraTech's Project Stalker, combining the intellect of a human with the ferocity and strength of a velociraptor and cybernetic augmentations.
Gray Fox (Metal Gear) has been subjected to various super-soldier experiments, including the CIA's Perfect Soldier Project and the Cyborg Ninja Project.
Carnage (Marvel: The Amazing Spider-Man 2) is a product of Oscorp's Venom Project, which involves weaponizing nanite armor.
James Buchanan "Bucky" Barnes (Marvel Cinematic Universe)
James "Logan" Howlett/Wolverine (Marvel Comics) is a product of the Weapon X super-soldier project.
Fantomex (Marvel Comics) a Sential/Mutant hybrid that was created by Weapon Plus.
Omega Red (Marvel Comics) is the Soviet Union's answer to Captain America.
The Predator X (Marvel Comics) is a bioweapon commissioned by William Stryker for the sole purpose of hunting and killing mutants.
The American Kaiju (Marvel Comics) is a product of Project Troubleshooter, an attempt to recreate the Super-Soldier Serum by using Gamma enhancements, Mutant Growth Hormone, Pym Particles and the Connors Formula.
Solid Snake (Metal Gear) is a product of the Les Enfants Terribles project, meant to create clones of Big Boss, the greatest soldier of the 20th century.
Liquid Snake (Metal Gear), Solid Snake's twin brother, is also a product of the Les Enfants Terribles project.
Gene (Metal Gear Solid: Portable Ops) is the end result of the Successor Project.
The T-103 "Tyrant" (Resident Evil) is an elite, mass-produced B.O.W developed by the Umbrella Corporation.
The Nemesis-T Type (Resident Evil) is a variant of the "Tyrants" and one of the most powerful B.O.W.s ever created by the Umbrella Corporation.
Khan Noonien Singh (Star Trek)
Jak (Jak and Daxter) is a product of Baron Praxis' Dark Warrior Program.
John-117 (Halo) is a Spartan-II, a genetically and cybernetically enhanced human super soldier trained since childhood.
Sephiroth (Final Fantasy VII)
SOLDIERs (Final Fantasy VII) are all infused with the cells and genes of an extraterrestrial which significantly increases their overall physiology and condition.
Commander Shepard (Mass Effect)
Kanden (Metroid Prime Hunters)
Grunt (Mass Effect) was engineered to be the ultimate krogan.
Blacklight viral Super Soldier (Prototype 2)
Wes Keenan (Smallville) was used as a prototype for Lex Luthor's Project Ares, possessing the DNA and powers of several metahumans, as well as the Phantom Zone escapee Titan.
Four of the Vinsmoke siblings (One Piece) have been genetically enhanced to be the ultimate soldiers for warfare.
The Indoraptor (Jurassic World: Fallen Kingdom) was designed by Dr. Henry Wu to be the perfect military weapon, with instincts and reflexes far surpassing any human soldier.
Shadow the Hedgehog (Sonic the Hedgehog)
Super Soldier (Valkyrie Crusade)
Space Marines (Warhammer 40,000)
Witchers such as Geralt of Rivia (The Witcher) are mutated humans created to fight the various monsters living on the Continent.