Riptor (Killer Instinct) is a product of UltraTech's Project Stalker, combining the intellect of a human with the ferocity and strength of a velociraptor and cybernetic augmentations.
Solid Snake (Metal Gear) is a product of the Les Enfants Terribles project, meant to create clones of Big Boss, the greatest soldier of the twentieth century.
Liquid Snake (Metal Gear), Solid Snake's twin brother, is also a product of the Les Enfants Terribles project.
Max Guevara (Dark Angel) is a member of the X5 series of super-soldiers.
Cy-Gor (Image Comics) is the end result of Project SIM: a half-man, half-gorilla monster enhanced with cybernetics.
The Corpse Corps (Blood+) are artificial chiropterans created for the sole purpose as military weapons.
The Nemesis T-Type (Resident Evil) is one of the most powerful B.O.W.s ever created by the Umbrella Corporation.
River Tam (Firefly) was partially transformed into a psychic super-soldier by the Alliance.
Gray Fox (Metal Gear) has been subjected to various super-soldier experiments, including the CIA's Perfect Soldier Project and the Cyborg Ninja Project.
Eclipse the Darkling (Archie's Sonic the Hedgehog) is a Black Arms super-soldier created to be his species' answer to Shadow the Hedgehog.
Kasumi Alpha (Dead or Alive) is a product of DOATEC's Project Alpha., a super-soldier project centered around clones of the kunoichi Kasumi.
Alpha-152 (Dead or Alive) is the penultimate result of Project Alpha.
Phase 4 (Dead or Alive) is the prototype of Project Alpha's final result.
Omega Red (Marvel Comics) is the Soviet Union's answer to Captain America.
Wolverine (Marvel Comics) is a product of the Weapon X super-soldier project.
Khan Noonien Singh (Star Trek)
Jak (Jak and Daxter) is a product of Baron Praxis' Dark Warrior Program.
Buddy Blank, the One Man Army Corps (DC Comics)
Sephiroth (Final Fantasy)
Space Marines (Warhammer 40,000)
Commander Shepard (Mass Effect)
Kanden (Metroid Prime Hunters)
Grunt (Mass Effect) was engineered to be the ultimate krogan.
Gene (Metal Gear Solid: Portable Ops) is the end result of the Successor Project.
Adam (Buffy the Vampire Slayer) is the end result of the 314 Project, a military super-soldier program meant to combine the advancement of technology with the intelligence and adaptability of humans and the superior strength and emotional detachment of demons.
SOLDIERs (Final Fantasy 7) are all infused with the cells and genes of an extraterrestrial which significantly increases their overall physiology and condition.
Blacklight viral Super Soldier (Prototype 2)
Super Soldier (Valkyrie Crusade)
Cell (Dragon Ball) is Dr. Gero's ultimate creation, a biological android containing the DNA and combined powers of the Z Fighters, Frieza, and King Cold for the sole purpose of destroying Goku.
Wes Keenan (Smallville) was used as a prototype for Lex Luthor's Project Ares, possessing the DNA and powers of several metahumans, as well as the Phantom Zone escapee Titan.
The Predator X (Marvel Comics) is a bioweapon commissioned by William Stryker for the sole purpose of hunting and killing mutants.
James Buchanan "Bucky" Barnes (Marvel Universe)