The user is a vampire that has been modified or evolved due to a variety of causes, such as evolution, genetic experiments, mutation, enchantment, having powers bestowed upon them by other beings or sources, through birth, and training in order to obtain said powers.
Alternatively, the user is a member of species such as homo superior, who was vampirized, giving them vampiric powers in addition to their pre-existing power sets. They could also be vampires that have been modified through rational or irrational means.
Modified Vampires can also be divided into two categories:
Metavampires of this category gain their powers via evolution, birth, genetic engineering, or exposed to radiation or biohazardous substances, like mutagens, or any other methods that involves genetic experimentation in that regard.
In one way or another, certain metavampires that are of this classification will may have minor physical changes, like their irises changing to any color like a fiery shade of red, yellow, purple, etc, retractable claws or spikes, color of the skin being changed, among others. In fact, these kinds of supervampire will be able to possess powers without their physiology being altered.
By this category metavampires gain their powers by having their abilities bestowed upon them by supernatural beings, enchantment, training to self-bestow their powers like Telekinesis for example, being blessed or granted wishes to obtain their powers, and among any other methods without any genetic tinkering.
Unlike rational-based supervampires this category of vampire wouldn't have to be able to suffer mutations and instability of their deoxyribonucleic acid, which can be caused in certain ways. Unlike like rational based these kinds of Supervampires are more likely to maintain their humanity because they don't share the same genetic unpredictably that rational-based supervampires are more likely to have.
Peter Benjamin Parker/Spider-Man (Marvel Comics); temporarily
Jubilation Lee/Jubilee (Marvel Comics); formerly
Jacqueline Falsworth/Spitfire (Marvel Comics)
Metahumans of Earth-2010 (Marvel Comics)
James Howlett/Wolverine (Marvel Comics: What If)
X-Vampires (Marvel Comics: What If?)
Nerd Hulk (Ultimate Comics Avengers)
Augustine Vampires (The Vampire Diaries)
Jared Nomak (Blade II) is the first of the Reapers, an artificially-created race of super vampires.
Despite having become a vampire, Ringo (Boktai) retains the blood of a solar child in his veins, allowing him to wield the Gun del Sol.
Yuki Makimura (Buffy the Vampire Slayer) is the first known Slaypire, a Slayer-turned-vampire, giving her the combined powers of both and making her stronger than either.
As a Slaypire, Simone Doffler (Buffy the Vampire Slayer) easily overpowers Buffy Summers, a Slayer of great power and experience.
Like the rest of the Blood League, The Flash of Earth 43 (DC Comics) was turned into a vampire after being bitten by Batman.
Ororo Munroe/Bloodstorm (Marvel Comics) is an alternate reality version of Storm who was turned into a vampire by Dracula.
A temporarily vampirized Peter Parker/Spider-Man (Marvel Comics) attacking Blade.
Jacqueline Falsworth/Spitfire's (Marvel Comics) mutant power of super speed first manifested through a combination of being bitten by the vampire Baron Blood and being transfused with the artificial blood of the synthezoid Jim Hammond.
The James Howlett/Wolverine of Earth-9140 (Marvel Comics) is an alternate version of Wolverine who was killed and resurrected as a vampire by Dracula with the rest of the X-Men. However, Wolverine's will was too strong for Dracula's hypnotism and he killed him, becoming Lord of the Vampires.
The X-Vampires (Marvels Comics) are an alternate reality version of the X-Men who were killed and resurrected by Dracula to serve as his vampiric servants until he was killed and replaced as Lord of the Vampires by Wolverine.
Earth-2010 (Marvel Comics) is an alternate universe where the entire human population of Earth were transformed into vampires, including mutants, and human mutates.
Nerd Hulk (Ultimate Marvel) is a clone of Bruce Banner with the intelligence of Banner, the strength of the Hulk, and all the abilities of a vampire after being turned into one by the King of the Vampires.
Augustine Vampires (The Vampire Diaries) are vampires that have been modified with the Ripper Compound, giving them enhanced powers and a cannibalistic taste for other vampires' blood.