Users possess immense combat skills, both offensive and defensive, that far surpass other beings of their verse. Their skills may be highly innate superhuman, honed or both.
This encompasses speed, strength, precision, reflexes, technique, analysis, control, adaptation, and all aspects of practical fighting. Depending on the users, they may be specialized in specific types of weaponry (melee, ranged, natural, etc.), and invariably wield them with surreal efficiency. Most observers are simply incapable to understand what's happening, with only a user being able to gauge the skill of another.
Scathach (Valkyrie Crusade) is the goddess of melee and magic.
Yang's (Final Fantasy IV) combat skills are so highly trained that he is capable of fighting and defending against an army of soldiers and monsters all by himself.
Aside from his immense power, Raiden (Mortal Kombat) has an encyclopedic knowledge of over 700 martial arts fighting styles, which no human, mortal, or any other God has.
Shao Kahn's (Mortal Kombat) fighting prowess, as well as his necromancy, astral manipulation abilities, and his immense godly strength are so high, it enables him to fight on equal footing with Raiden and is why Shao Kahn is the most dreaded emperor of the realms.
Kratos' (God of War) immense strength and combat skills allow him to defeat entire armies of monsters, the entire Greek pantheon, and the nine Valkyries.
Raidou (Dead or Alive) is an extremely dangerous ninja due to his immense power and supreme fighting skills.
At the time of fighting the cult and as well as its past leader, Jakob/Cult Leader (New Blood Interactive's DUSK) had fought them with absolutely no help whatsoever, and this had caught Nyarlathotep's attention into being interested in his potential, and decided to give him the position as his own henchman. But as Dusk Dude eventually came to their fruition in an attempt to defeat them and ending their cosmic rampage once and for all, he actually managed to put an end to Jakob due to how more superior he is in comparison to his combat expertise.
Yaiba (Ninja Gaiden) is called the Demon Ninja due to his immense power and fighting skills which are nearly on par with Ryu.
Ryu Hayabusa (Ninja Gaiden) as most powerful ninja ever existed, is capable of slaying the most powerful supernatural beings such as Greater Fiends and Archfiends.
Heihachi Mashima (Tekken) is a powerful martial art master able to fight his grandson, Kazuya in his Devil form on an equal level.
Even though Sam "Serious" Stone (Serious Sam series) is the pinnacle of heroism, sheer badassery, and with NETRICSA being in sync with him, he can eradicate entire armies of Mental's monsters, managed to defeat Ugh-Zan III on his own, and he fought on equal footing with Kukulkan the Wind God.