Users possess immense combat skills, both offensive and defensive, that far surpass other beings of their verse. Their skills may be innate, honed or both.
This encompasses speed, strength, precision, reflexes, technique, analysis, control, adaptation, and all aspects of practical fighting. Depending on the users, they may be specialized in specific types of weaponry (melee, ranged, natural, etc.), and invariably wield them with surreal efficiency. Most observers are simply incapable to understand what's happening, with only a user being able to gauge the skill of another.
Urashiki Ōtsutsuki (Boruto: Naruto Next Generations)
Various Characters (One-Punch Man)
Honoka (The Third: Girl with the Blue Eye)
Sung Jin-Woo (Solo Leveling); after his Second Awakening
Various Characters (Yongbi the Invincible)
Various Characters (Yu Yu Hakusho)
Clark Kent/Kal-El/Superman (DC Comics)
Diana/Wonder Woman (DC Comics)
The Drowned (DC Comics)
Olympia (Hero Heights)
Power Rangers (Power Rangers)
Supreme (Image Comics)
Viltrumites (Image Comics)
Savage Dragon (Image Comics)
Thor Odinson (Marvel Comics)
James "Logan" Howlett/Wolverine (Marvel Comics)
Peter Parker/Spider-Man (Marvel Comics)
Gorgon/Tomi Shishido (Marvel Comics)
Danny Rand/Iron Fist (Marvel Comics)
Debbie Devizo (Supermansion)
Hercules Method Practitioners (The Strange Talent of Luther Strode)
Mr. Majestic (Wildstorm/DC Comics)
Miraculous wielders (Miraculous: Tales of Ladybug & Cat Noir)
Asura (Asura's Wrath)
Raidou (Dead or Alive)
Death (Darksiders 2)
Yang (Final Fantasy IV)
Sephiroth (Final Fantasy VII)
Kratos (God of War)
Baldur (God of War)
Raiden (Mortal Kombat)
Shao Kahn (Mortal Kombat)
Shinnok (Mortal Kombat)
Ryu Hayabusa (Ninja Gaiden)
Akuma (Street Fighter)
Gouken (Street Fighter)
Ryu (Street Fighter)
Heihachi Mishima (Tekken)
Kazuya Mishima (Tekken)
Jin Kazama (Tekken)
Scathach (Valkyrie Crusade)
Esdeath (Akame ga Kill) hailed as the strongest warrior of the Empire can single-handedly annihilate armies and even Teigu users.
Skull Knight (Berserk)
Nosferatu Zodd (Berserk)
Yoruichi Shihoin (Bleach) is one of the greatest martial art masters in Soul Society, able to take down an entire squadron of highly skilled Hakuda experts in seconds.
Claymores (Claymore) possess combat abilities far above human limits due to the fusion and grafting of Yoma flesh to their bodies...
...Teresa of the Faint Smile was said to be the strongest Claymore to ever have existed. As such she could effortlessly detect and kill Youma posing as humans...
....to the point where even the strongest Awakened Beings called her a monster.
Priscilla's (Claymore) combat skills increased tremendously during her awakening, taking down an above-abyssal awakened without sustaining any damage.
Alicia (Claymore) is one of the most skilled warriors, both in human and awakened form, thanks to her enormous natural abilities and extreme training.
Kurumi (Date A Live) as an S-Class Spirit can destroy an army of Bandersnatch robots by herself.
Son Goku (Dragon Ball Z)
Frieza (Dragon Ball Z)
Nappa (Dragon Ball Z)
Raditz (Dragon Ball Z)
Android 18 (Dragon Ball Z)
Android 17 (Dragon Ball Z)
A Devil who is also a martial art master, Sairaorg Bael (Highschool DxD) is able to defeat High-Class Devils using pure might and skill.
Issei Hyodou (Highschool DxD)
Vali Lucifer (Highschool DxD)
Hashirama Senju (Naruto), Konoha's First Hokage, was so overwhelmingly powerful and skilled that he was titled the God of Shinobi/Ninjas.
A (Naruto) was able to single-handedly fight off 10,000 Iwagakure shinobi for three days and three nights nonstop before finally succumbing to death.
Kokuyō (Boruto: Naruto Next Generations) is an artificial human who possesses superhuman combat skills.
The second-generation master in the art of Rasen, Tou (Kingdom) is a very proficient and deadly master swordsman, demonstrating incredible speed with his Faru Faru as he cuts down multiple men before they can even register his movements.
Earl Shi of the Wei Fire Dragons (Kingdom)
Gyou' Un (Kingdom)
Gai Mou of the Wei Fire Dragons (Kingdom)
Rin Ko of the Four Heavenly Kings (Kingdom)
Yo Tan Wa (Kingdom)
Shi Ryou (Kingdom)
Ren Pa (Kingdom)
Ri Shin (Kingdom)
Ou Hon (Kingdom)
Kou Yoku of the Thunder (Kingdom)
Kyou Kai (Kingdom)
Ou Ki, The Monstrous Bird of Qin (Kingdom)
Hou Ken, the Bushin (Kingdom)
Ba Jio, the Blade of the Mountain King (Kingdom)
Mou Bu (Kingdom)
Zen Ou of the Kanki Army (Kingdom)
Ever since his Second Awakening, Sung Jin-Woo (Solo Leveling) has...
Scathach (Valkyrie Crusade) is the goddess of melee and magic.
Yang's (Final Fantasy IV) combat skills are so highly trained that he is capable of fighting and defending against an army of soldiers and monsters all by himself.
Aside from his immense power, Raiden (Mortal Kombat) has an encyclopedic knowledge of over 700 martial arts fighting styles, which no human, mortal, or any other God has.
Shao Kahn's (Mortal Kombat) fighting prowess, as well as his necromancy, astral manipulation abilities, and his immense godly strength are so high, it enables him to fight on equal footing with Raiden and is why Shao Kahn is the most dreaded emperor of the realms.
Raidou (Dead or Alive) is an extremely dangerous ninja due to his immense power and supreme fighting skills.
Yaiba (Ninja Gaiden) is called the Demon Ninja due to his immense power and fighting skills which are nearly on par with Ryu.
Ryu Hayabusa (Ninja Gaiden) as most powerful ninja ever existed, is capable of slaying the most powerful supernatural beings such as Greater Fiends and Archfiends.
Heihachi Mashima (Tekken) is a powerful martial art master able to fight his grandson, Kazuya in his Devil form on an equal level.