The user possess unique metaphysical/paranormal qualities in their genetic code/biological essence and can either pass them down through the family line or share them with others via direct biophysical grafting.
Genesis Rhapsodos (Crisis Core -Final Fantasy VII)
The Noah Family (D.Gray-Man)
Necromorphs (Dead Space)
Jenova (Final Fantasy VII)
Toxzon (Max Steel)
Leviathans (Metroid Series)
Devil Gundam/Dark Gundam (Mobile Fighter G Gundam)
Hagoromo Otsutsuki (Naruto)
Kaguya Otsutsuki (Naruto)
Mitochondria Eve (Parasite Eve)
Saints (Rokka no Yuusha)
Alucard (Rosario + Vampire)
The Afflicted (Tomboy)
Vampires (Various Sources)
Werewolves (Various Sources)
Jenova (Final Fantasy VII) is a deadly parasitic entity of the cosmos whose consciousness lives on even within its very genetic structure.
Mitochondria Eve (Parasite Eve) can both manipulate as well as infuse her matriclinous template into other organisms.
The Dark Gundam (G Gundam) has the three theoretical technorganic capacities of self-regeneration, replication and evolution through usage of it's DG Cells.
Necromorphs like the Brethren Moons (Dead Space) are capable of transfusing their necrotic biomass into organic corpus stemming as large as planetary bodies to create more of their race.
The Leviathans (Metroid Prime) are living meteors animated by the sapient energy Phazon, an ergokinetic consciousness that can imprint on a target at a sub-molecular level bringing both organic and inorganic elements to life.
Kaguya Ōtsutsuki (Naruto), the Mother of All Chakra, can infuse her conciousness her very will unto a living cellular form called Black Zetsu.
Alucard the First Shinso (Rosario + Vampire Season II) has an overpowering influence over his own flesh and blood that can either create degenerate monsters or mutated gods.
The Noah Clan (D.Gray-Man) are the blood born sentient memories belonging to the original relatives on Noah's Ark. Every few millennia or so the Noah Gene will activate and overtake a random select of humanity, hosting the predatory persona's and mindsets of the clans more malicious aspects.