User can formulate symbols that can cause special events to occur, depending on the symbol that empowers the user, they can achieve a variety of abilities. With a great number of symbols that can be turned to magic, the user can do almost anything.
The Alpha Stigma (The Legend of the Legendary Heroes)
The Scotsman (Samurai Jack) wields a claymore with magic runes inscribed onto the blade. The runes grant the sword indestructibility, increase its destructive power, and the weirder gets resurrected as a ghost with the power of righteousness.
Oscar Brailsford (Seikoku no Dragonar) is one of the chosen by the Mother Dragon to carry the Seikoku Magic symbol.
Seikoku (Seikoku no Dragonar) is a magic symbol that used to tame dragons and can only have this tattoo by those who have chosen by the Mother Dragon.
A sigil trap for demons, Devil Traps (Supernatural) can trap demons and prevent them from using their powers...
...Devil's Trap Bullet can trap and bind demons to their possessed vessels.
Anti-Demon Possession Tattoos (Supernatural) are a method to ward off demonic possession...
...It features a pentagram, or endless knot, which is the reason why it protects those who wear this symbol.
Dean Winchester (Supernatural) using a Blood Magic Enochian Sigil to banish Zechariah.
Enochian Sigils (Supernatural)
The Mark of Cain (Supernatural)
Weiss Schnee (RWBY) can create glyphs that can be used in a variety of ways...
...to create a platform...
...to act as a shield...
...and to channel Dust to create ice.
Rune Knight (Valkyrie Crusade)
Rangda (Valkyrie Crusade) is an all-powerful witch that possess magic runes on her skin.
Clary (The Mortal Instruments: City of Bones) uses a rune to freeze demons in the air.
Mana Yanowa (Marvel Comics) casting a White Arts influenced symbol.
Mysterio (Marvel Comic)
Mystogan's (Fairy Tail) Five Layer Circle Sacred Song.
Freed Justine's (Fairy Tail) Dark Écriture.
Alphonse Elric (Fullmetal Alchemist)
May Chang (Fullmetal Alchemist) using Alkahestry, a Xingese variation of alchemy that draws power from the Earth's chi.
All Heart Kingdom mages (Black Clover) have adapted to the surplus of natural mana around their realm and can channel that mana into their spells using Mana Method to give simple or complex commands…
…Gadjah, a Stage Zero mage can use Mana Method to augment his defense or speed, as well as summoning real Lightning.
Luck Voltia (Black Clover) learned to use Mana Method and is able to use runes as platforms to further enhance his mobility and to use real lightning to transform into actual lightning.