The user can regenerate the length of their telomeres. Telomeres are a region of repetitive nucleotide sequences at each end of a chromatid, protecting the DNA fragments; they grow shorter as cell division occurs, an indication of the person getting older. By regenerating the lengths of telomeres, one can extend their own lifespan indefinitely.
Practitioners of the Hercules Method (The Strange Talent of Luther Strode)
Blood Orchids (Anacondas: The Hunt for the Blood Orchid)
Cure-All Elixir (Baccano)
Grand Panacea (Baccano)
God's Breath (Black Cat)
Lazarus Pits (DC Comics)
Ambrosia (Toaru Majutsu no Index)
Perrinia immortalis/"Blood Orchid" (Anacondas: The Hunt for the Blood Orchid), contains a unique, naturally generated chemical that extends an organism's telomeres, enabling those who consume them to live longer.
Thanks to his Body Supremacy, Stanton Parish (Alphas) has perfect cellular regeneration, repeatedly rejuvenating his telomeres and maintaining his youth for 200 years.
In addition to granting him vast regenerative powers, Tenzen Yakushiji's (Basilisk) symbiote also "eats" away the ravages of time, rejuvenating his telomeres and maintaining his youth for over 200 years.
10 years after Tenzen's death, Joujin (Basilisk) gained the symbiote that was Tenzen's spirit, "eating" away any wounds and aging the same way Tenzen's symbiote did.
Thanks to the God's Breath nanomachines in his body, Creed Diskenth (Black Cat) possesses such perfect regeneration that his telomeres are constantly relengthened, maintaining his youth and peak condition.
In addition to healing the sick and being able to resurrect the dead, the Lazarus Pits (DC Comics) also rejuvenate the telomeres of whoever bathes in them. Thus, by continuously using the pits, Ra's al Ghul has maintained his age at its prime for over 600 years.
By continuously lengthening her telomeres, Tomiko Asahina (From the New World) has not only remained young and beautiful, but has lived for over 267 years.
Adam Monroe's (Heroes) cells have regenerated so many times that they are now regenerating and dying in equilibrium, constantly rejuvenating his telomeres and rendering him young for over 400 years.
Mystique (Marvel Comics) rejuvenates her cells whenever she metamorphoses, thus rejuvenating her telomeres, maintaining her age at her prime.
Wolverine (Marvel Comics) possesses regenerative powers of such levels that they even re-lengthen his telomeres, maintaining his age at his prime.
Like his nemesis Wolverine, Sabretooth (Marvel Comics) possesses regenerative powers of such levels that they even re-lengthen his telomeres, maintaining his age at his prime.
Inheriting his father's healing factor, Akihiro Daken (Marvel Comics) constantly regenerates his telomeres, maintaining his age at its prime.
As his healing factor is derived from Wolverine's, Deadpool (Marvel Comics) possesses the same degree of regeneration, his telomeres constantly re-lengthening and maintaining his age at its prime...
...to the extent his counterpart in the Earth-80521 reality was still alive and active as Deadpool 800 years into the future.
The mitochondria in Aya Brea's (Parasite Eve) body constantly rejuvenate her telomeres, making her appear to be in her early twenties despite actually being in her late thirties.
Using the Reihado-ken technique, Genkai (Yu Yu Hakusho) manipulates her cells, regenerating her telomeres and temporarily restoring her to her physical prime.
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