Transcendent Micromutated Human Physiology (Rational Only)
Users are superior humans that are so powerful they can be considered first-rate deities. Having a level of power on a gigantic scale (planetary, cosmic, universal, multiversal, and even omniversal) that they can use to enhance all of their abilities (natural, supernatural, etc,) to godlike levels, making them nearly all-powerful and virtually unstoppable beings.
Under rational circumstances, users can gain such power by reaching the peak of their evolutionary process or by using extremely advanced scientific methods that can deify their classification of superhumans, granting new and unusual powers that are immensely difficult if not impossible to achieve. Users of this category can achieve an array of abilities that can intuitively manipulate many if not all aspects of reality.
Under irrational circumstances, users can gain such power by transcending their status to higher levels that's beyond most superhumans or by obtaining a source of ultimate power, which can grant them newly found supernatural abilities that surpass all other superhuman beings in their universe.
Powers that users may possess, but are not limited to:
Rachel Summers/Prestige (Marvel Comics) is classified as a "Class Omega (contact)", who inherited enormous psionic powers from her mother, Jean Grey, and the Phoenix Force.
Eternals/Homo Immortalis (Marvel Comics) are Humans that have been genetically perfected by Nezarr the Calculator, who is one of the Celestials.
New Sun (Marvel Comics) is the result of an alternate reality version of Remy Etienne LeBeau/Gambit having reached full-on the apex of his powers.
Even though he's the new king of the Inhumans, Blackagar Boltagon/Black Bolt (Marvel Comics) is an insanely powerful Inhuman, which is all thanks to having Ballistic Scream, powerful enough to demolish massive planets.
The Unspoken (Marvel Comics) former leader of the Inhumans can control the way of terregenesis to simulate any superhuman power he desires.
En Sabah Nur/Apocalypse (Marvel Comics) was the first mutant in the world.
Joshua Foley/Elixir (Marvel Comics) is both an Omega Level Mutant and Healer.
Quintavius Quirinius Quire/Kid Omega (Marvel Comics) is both an Omega Class Mutant and an Omega Class Telepath. Unlike Charles Francis Xavier whose Telepathy can reach 250 miles, his level of Telepathy can reach vast distances.
Being one of the most powerful Psiots to date who rivals Toyo Harada in terms of power, Peter Stanchek/Sting (Valiant Entertainment Comics) has plenty of psychic abilities, but what makes him uniquely powerful is the fact that he can switch the powers of others on or off.
Having psychic abilities on a godly scale, Toyo Harada (Valiant Entertainment Comics) is a Psiot of virtually almighty capability, rivaled only by fellow omega psiot Peter Stanchek.
After bonding to the Philosopher's Stone, Savitar (Arrowverse) could draw much more power from the Speed Force than most other conduits, to the extent he declared himself the God of Speed and ruler of the Speed Force itself.
Being the most powerful Esper possible, Tatsumaki/Tornado of Terror (One-Punch Man) has psychic powers that are on par with Geryuganshoop.
Flashy Flash (One-Punch Man)
In his adult years, Naruto Uzumaki (Naruto) has come to be known as the strongest shinobi of his era and in history, having been able to match, defeat, or help to defeat the most dangerous figures in history, and is able to have command of overwhelming Jutsu thanks in part to the chakra of Nine-Tailed Fox Kurama and the chakra of Hagoromo Ōtsutsuki.
A/Third Raikage (Naruto) is undoubtedly an immensely powerful shinobi who’s taijutsu abilities are enough to defeat various shinobi in one single move because of how powerful the taijutsu skills are. The most powerful ability that he has is ‘’Hell Stab’’, which allows him to infuse his fingertips with lightning chakra to impale his enemies.
The powers that Gengetsu Hōzuki (Naruto) uses are on a godly scale that he can be considered a one-man army on multiple levels, especially the fact that he can single-handedly kill Mū rather easily.
Famed as the strongest ninja of his time, Hashirama Senju (Naruto) was regarded as the God of Shinobi as he possessed not only immense physical and chakra prowess, but his mastery over a multitude of Jutsu and nature transformations have allowed him to overpower eight of the nine tailed beast,...
...and even overpower and defeat his rival Madara who also had immense power.
Having an insane amount of powers and an unnatural level of combat prowess, Madara Uchiha (Naruto) is the most powerful individual in the Uchiha clan hierarchy, having independently defeated the Fourth Division with zero cooperation with his own allies.
One of the strongest Kages, Mei Terumī's (Naruto) deadly mastery with her Lava Release kekkei genkai allows her to produce potent techniques like the ‘’Lava Release: Melting Apparition Technique’’, which can severely incinerate her opponents...
...and being able to rival Madara Uchiha to a certain extent during the Fourth Great Shinobi War.
Might Guy’s (Naruto) proficiency in the use of the Eight Gates abilities in conjunction with taijutsu made him formidable in battle....
...Even Madara himself who gained the power of the Ten-Tails declared and acknowledged him the strongest taijutsu master.
Mū (Naruto) of the Iwagakure village, was an Empowered Human of godly power, having successfully killed Gengetsu Hōzuki even though he risked his own life in the process.
Ōnoki (Naruto) is incredibly skilled at using powers primarily in association with the earth, and with the ‘’Dust Release: Detachment of the Primitive World Technique’’ power at his disposal, he can outmatch not only Deidara, but among other opponents he happened to be fighting against.
Having incredible prowess as a kunoichi, Tsunade (Naruto) is one of the strongest Kage, being able to defeat Orochimaru near single-handedly even though he has a massive powerset compared to her own, and even broke through Madara's Susanoo, an "absolute defense", with only a few hits.
Born with all manner of psychic abilities, Kusuo Saiki (Saiki Kusuo no Psi-nan) is a powerful psychic whose power continues to grow with each day.
Having exceeded the limit of his Alter Power, Ryūhō Ryu (s-Cry-ed) became one the most power Alter users on the planet, able to harmonize with his Zetsuei into his Zetsuei Touryudan form allowing him to move at near light speed and cut the fabric of space to bypass conventional defensive methods.
Having exceeded the limit of his Alter Power, Kazuma (s-Cry-ed) became one the most power Alter users on the planet, able to merge with his Shell Bullet into his Proud Fist form. With his power, Kazuma can create rifts in space with his punches, pulverizing anything that gets in his way.
Shigeo Kageyama/Mob (Mob Psycho 100) possesses tremendous psychic power and is arguably the most powerful esper alive.
While biologically pure human, Escanor (Seven Deadly Sins) has godly powers unmatched by almost any being. This is due to inherit the power of the Archangel Mael...
...and allows Escanor to fight evenly with the Demon King himself.
As a "Player," Sung Jin-Woo (Solo Leveling) can become more powerful by gaining experience and leveling up as if he were an RPG character...
Sung Il-Hwan (Solo LeveLing)
Hwang Dong-Su (Solo Leveling)
Baek Yoon-Ho (Solo Leveling)
One of the 10 S-Rank Hunters of South Korea and nicknamed The Ultimate Soldier, Choi Jong-In (Solo Leveling) is a powerful mage class hunter that specializes in fire magic...
...that's it been described as tremendous inferno as he annihilates powerful Dungeon monsters with ease.
Go-Gun Hee (Solo Leveling)
Cha Hae-In (Solo Leveling)
Atsushi Kumamoto (Solo Leveling)
Via the Linchpin, Shin (The New Gate) had been given godly potential as a High Human.
Categorized as an S-Class individual, Shinobou Sensui (Yu Yu Hakusho) has ten times the spiritual energy Yusuke himself and wields the Sacred Energy.
Verified by Koenma to be the strongest fully-human fighter on Earth, Kazuma Kuwabara (Yu Yu Hakusho) is not only far stronger and faster than the average human, but he also possesses S-class Spirit Energy and can create his Dimension Blade.
Upon being bestowed power by the Seraphim, the Doom Slayer (Doom), gained immense physical prowess, in addition to being unable to age, no longer needing rest, food or water to survive and most notably, gain strength for every demon he killed.
Prior to becoming Nyarlathotep's enforcer as well as a cult leader, Jakob/Cult Leader (New Blood Interactive's DUSK) was a machiavellian that managed to both defeat and kill all the cult members and its leader all by himself, and this automatically gave the aforementioned Deity some attention and chosen him as his own subordinate. And...