The user has the power to place specific authorizations/authentications on objects and items, ensuring that only specific individuals can utilize them, if even pick them up.
In numerous cases, while unauthorized users can utilize objects, it may have devastating side effects.
In various incarnations, Excalibur (Arthurian Legend) can only be drawn and wielded by the rightful king of Camelot...
...such as Hellboy (Hellboy/BPRD)...
...and Sonic (Sonic the Hedgehog).
The Gun Del Sol (Boktai) can only be wielded by a solar child like Django...
...this still applies even if the solar child has become a vampire, as with Django's father Red Ringo.
The Carpathian Dragons (BloodRayne 2) are vampiric handguns that can only be used by a dhampir like Rayne.
The Vampire Killer (Castlevania) can only be properly used by the Belmont Clan; any wielder who is not a direct descendant will have their life force drained away.
Emi Yusa's (The Devil is a Part-Timer!) sacred sword, Better Half, can only be wielded by a Nephilim.
The Tessaiga (InuYasha) possesses an anti-yokai barrier placed upon it by Toga, ensuring that only hanyo and yokai who show compassion for humans and actively think about protecting humans can draw out its full power, much less touch it...
...repelling and burning Sesshomaru, who lacks those qualities, on contact.
Due to Odin's (Marvel Comics) enchantments, only those deemed worthy can use Mjolnir.
The Uni-Power (Marvel Comics) only bestows the power and persona of Captain Universe upon a host worthy of it and will immediately strip said host of its power if they use or intend to use the granted abilities in a detrimental or criminal fashion.
The Silver Crystal (Sailor Moon) can only be used by a member of the Moon Kingdom dynasty.
Uncle Chuck (Sonic the Hedgehog SatAM) created the Power Rings specifically for Sonic; thus, only Sonic can truly harness their power.
Merlin (TYPE-MOON) was able to enchant caliburn so only a person worthy of ruling Camelot can wield it.